https://m2.mtmt.hu/ eng 2026-06-24 22:26 JournalArticle 3322273 VALIDATED true Laboratory for Neuron Glia Circuit, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Hirosawa 2-1, Japan Neuronal Networks Group, College of Medical and Dental Sciences, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, United Kingdom Laboratory for Behavioral Genetics, RIKEN Brain Science Institute, Wako, Japan Department of Biochemistry, Kitasato University School of Medicine, Sagamihara, Japan Saitama University Brain Science Institute, Saitama, Japan Export Date: 22 March 2025; Cited By: 74; Correspondence Address: H. Hirase; Laboratory for Neuron Glia Circuit, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Hirosawa 2-1, Japan; email: hirase@brain.riken.jp; CODEN: EJONE 0 2018-01-25T08:43:21.000+0000 false 3322273 2026-05-18T03:41:04.132+0000 2024-12-06T17:46:01.425+0000 2018-01-24T09:06:09.000+0000 true 10009549 Sík Attila /api/author/10009549 Author true 10009549 2025-03-22T15:53:17.657+0000 2025-03-22T15:53:17.657+0000 2024-12-06T17:46:01.598+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Shinohara, Y Hippocampal CA3 and CA2 have distinct bilateral innervation patterns to CA1 in rodents. true true /api/journal/1510 REVIEWED true false 1510 false 1510 true 0953-816X 1460-9568 Journal FOREIGN 35 5 702 710 702 9 2012 Ipsilateral and contralateral hippocampal CA3-CA1 and CA2-CA1 projections were investigated in adult male Long-Evans rats by retrograde tracing. Injection of the retrograde tracer cholera toxin subunit B in the strata oriens and radiatum of dorsal CA1 resulted in labeling of predominantly pyramidal cells in ipsilateral and contralateral CA3 and CA2. The contralateral and ipsilateral anterior-posterior extents of CA3 innervation to CA1 were similar. Fifteen to twenty per cent of the hippocampus proper cells that give rise to CA1 stratum oriens innervation were CA2 pyramidal cells, whereas CA2 cells were a mere 3% for CA1 stratum radiatum innervation. The preferred projection of CA2 pyramidal cells to the CA1 stratum oriens was also manifested in transgenic mice that express GFP under the control of the CACNG5 promoter, in which CA2 cells express high amounts of GFP. The ratios of ipsilateral to contralateral projections were compared. For the CA3-CA1 connection, we found that dorsal CA1 stratum radiatum received more ipsilateral projections whereas CA1 stratum oriens received more contralateral innervation. Interestingly, ipsilateral connections dominated for both CA2-CA1 stratum oriens and CA2-CA1 stratum radiatum. These results demonstrate that the primary intrahippocampal target of CA2 pyramidal cells is the ipsilateral CA1 stratum oriens, in contrast to CA3 cells which project more diversely to bilateral CA1 regions. Such innervation patterns may suggest differential dendritic information processing in apical and basal dendrites of CA1 pyramidal cells. 2018 806982 true true true false false NONE 2026-05-18 false true 10009549 Sík Attila /api/author/10009549 Author true 10009549 78 0 78 75 2 78 78 74 75 78 78 75 75 75 3 0 78 75 78 75 0 3 3 Folyóiratcikk Journal Article 24 75 Könyvrészlet Chapter in Book 25 3 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2012 0 2 2 2 2 2013 0 3 2 3 2 2014 0 7 7 7 7 2015 0 1 1 1 1 2016 0 6 6 6 6 2017 0 7 6 7 6 2018 0 10 10 10 10 2019 0 9 9 9 9 2020 0 3 3 3 3 2021 0 7 7 7 7 2022 0 6 6 6 6 2023 0 8 7 8 7 2024 0 5 5 5 5 2025 0 4 4 4 4 Q1 false false false false 2019-01-31T22:59:00.000+0000 2018-01-24T09:44:47.000+0000 1 20 0 9 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 9753519 /api/authorship/9753519 1 0.11111111 true false Shinohara Y true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27515054 true PersonAuthorship 9753520 /api/authorship/9753520 2 0.11111111 false false Hosoya A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27515053 true PersonAuthorship 9753521 /api/authorship/9753521 3 0.11111111 false false Yahagi K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27515052 true PersonAuthorship 9753522 /api/authorship/9753522 4 0.11111111 false false Ferecsko AS true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27515051 true PersonAuthorship 9753523 /api/authorship/9753523 5 0.11111111 false false Yaguchi K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27515050 true PersonAuthorship 9753524 /api/authorship/9753524 6 0.11111111 false false Author 10009549 /api/author/10009549 Sík Attila true 10009549 true Sik A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27515049 true PersonAuthorship 9753525 /api/authorship/9753525 7 0.11111111 false false Itakura M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27515048 true PersonAuthorship 9753526 /api/authorship/9753526 8 0.11111111 false false Takahashi M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27515047 true PersonAuthorship 9753527 /api/authorship/9753527 9 0.111 false true true Hirase H true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27515046 true PublicationIdentifier 1265649 /api/publicationidentifier/1265649 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1111/j.1460-9568.2012.07993.x https://doi.org/10.1111/j.1460-9568.2012.07993.x false 1705941 true PublicationIdentifier 1265647 /api/publicationidentifier/1265647 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000301119000007 https://www.webofscience.com/wos/woscc/full-record/000301119000007 false 1706018 true PublicationIdentifier 1265648 /api/publicationidentifier/1265648 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus 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/api/keyword/3497 true 3497 true Keyword 7927 /api/keyword/7927 true 7927 true Keyword 21379 /api/keyword/21379 true 21379 true Keyword 1008193 /api/keyword/1008193 true 1008193 true Keyword 1284917 /api/keyword/1284917 true 1284917 true Keyword 1466737 /api/keyword/1466737 true 1466737 true SjrRating 5671842 /api/sjrrating/5671842 22 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2801 /api/classificationexternal/2801 true 2801 true Q1 DIRECT true 5671842 true /api/publication/3322273 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Shinohara Y </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hosoya A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yahagi K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ferecsko AS </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yaguchi K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009549"><a href="/gui2/?type=authors&mode=browse&sel=10009549" target="_blank">Sik A (<span class="authorship-author-name">Sík Attila</span> <span class="authorAux-mtmt"> Idegtudomány</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Itakura M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Takahashi M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hirase H ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3322273" target="_blank">Hippocampal CA3 and CA2 have distinct bilateral innervation patterns to CA1 in rodents.</a></div> <div> <span class="journal-title">EUROPEAN JOURNAL OF NEUROSCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0953-816X">0953-816X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1460-9568">1460-9568</a>)</span>: <span class="journal-volume">35</span> <span class="journal-issue">5</span> <span class="page"> pp 702-710 </span> <span class="year">(2012)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1111/j.1460-9568.2012.07993.x" target="_blank" href="https://doi.org/10.1111/j.1460-9568.2012.07993.x"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000301119000007" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000301119000007"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84857995750" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84857995750"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="22339771" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22339771&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 78</span> | Independent citation: 75 | Self citation: 3 | Unknown citation: 0 | Number of citations in WoS: 74 | Number of citations in Scopus:&nbsp;75 | WoS/Scopus assigned:&nbsp;78 | Number of citations with DOI:&nbsp;78 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3322273&sort=publishedYear,desc&sort=title"> Number of cited publications: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 3322273</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 3322273</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2024.12.06. 18:46 Róbert Milánkovics (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Laboratory for Neuron Glia Circuit, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Hirosawa 2-1, Japan Neuronal Networks Group, College of Medical and Dental Sciences, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, United Kingdom Laboratory for Behavioral Genetics, RIKEN Brain Science Institute, Wako, J...</pre> </div></div>