https://m2.mtmt.hu/ eng 2026-05-10 05:02 PublicationOther 33209367 ADMIN_APPROVED true 0 false 2025-12-02T13:01:16.305+0000 2025-09-08T07:50:49.639+0000 2022-11-05T17:45:29.069+0000 true 10075617 Oláh Csaba Zsolt /api/author/10075617 Author Csaba Zsolt Oláh (idegsebészet) true 2025-09-03T14:31:48.664+0000 2025-09-03T14:31:48.664+0000 2025-09-08T07:50:49.848+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin Edit Csajbók (SE_KK_Admin5_CSE, admin) true 10015544 true true 29 29 /api/publicationtype/29 PublicationType Miscellaneous 15 true 29 PublicationOther true 10000361 Publication in repository true 29 29 /api/publicationtype/29 PublicationType Miscellaneous 15 true 29 PublicationOther /api/subtype/10000361 Csak repozitóriumban hozzáférhető közlemény SubType Publication in repository (Miscellaneous) 1582 true 10000361 true 1 /api/category/1 Category Scientific true 1 Gergely, Tibor Kozma 2022 The polyethylene-glycol (PEG)-containing Covid-19 vaccines can cause hypersensitivity reactions (HSRs), or rarely, life-threatening anaphylaxis. A causal role of anti-PEG antibodies (Abs) has been proposed, but not yet proven in humans. The 191 blood donors in this study included 10 women and 5 men who displayed HSRs to Comirnaty or Spikevax Covid-19 vaccines with 3 anaphylaxis. 118 donors had pre-vaccination anti-PEG IgG/IgM values as measured by ELISA, of which >98% were over background regardless of age, indicating the presence of these Abs in almost everyone. Their values varied over 2-3 orders of magnitude and displayed strong left-skewed distribution with 3-4% of subjects having >15-30-fold higher values than the respective median. First, or booster injections with both vaccines led to significant rises of anti-PEG IgG/IgM with >10-fold rises in about ∼10% of Comirnaty, and all Spikevax recipients, measured at different times after the injections. The anti-PEG Ab levels measured within 4-months after the HSRs were significantly higher than those in nonreactors. Serial testing of plasma (n=361 tests) showed the SARS-CoV-2 neutralization IgG to vary over a broad range, with a trend for biphasic dose dependence on anti-PEG Abs. The highest prevalence of anti-PEG Ab positivity in human blood reported to date represents new information which can most easily be rationalized by daily exposure to common PEG-containing medications and/or household items. The significantly higher, HSR-non-coincidental blood level of anti-PEG Abs in hypersensitivity reactor vs. non-reactors, taken together with relevant clinical and experimental data in the literature, suggest that anti-PEG Ab supercarrier people might be at increased risk for HSRs to PEG-containing vaccines, which themselves can induce these Abs via bystander immunogenicity. Our data also raise the possibility that anti-PEG Abs might also contribute to the reduction of these vaccines’ virus neutralization efficacy. Thus, screening for anti-PEG Ab supercarriers may identify people at risk for HSRs or reduced vaccine effectiveness. true false 2022 true false false true false NONE 2025-12-02 false 5 0 4 3 2 4 4 4 3 4 4 3 3 3 2 0 5 3 4 3 0 1 1 Folyóiratcikk Journal Article 24 4 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 1 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 5 3 5 3 false false false false 2023-02-03T17:45:29.864+0000 Elméleti Egészségtudományok Intézete (ME / ETK); Gyakorlati Módszertani és Diagnosztikai Intézet (ME / ETK); Nanomedicina Kutató és Oktató Központ (SE / AOK / I / TMI); Transzlációs Medicina Intézet (SE / AOK / I); Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 8 61 5 12 0 false Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 104128632 /api/authorship/104128632 Gergely, Tibor Kozma [Kozma, Gergely Tibor (Immunológia, Mole...), author] Nanomedicina Kutató és Oktató Központ (SU / FM / I / TMI); Transzlációs Medicina Intézet (SU / FM / I) 1 0.083 true false Author 10024742 /api/author/10024742 Gergely Tibor Kozma (Immunológia, Molekuláris biológia) Kozma Gergely Tibor true 10024742 true Gergely Tibor Kozma true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104128633 /api/authorship/104128633 Tamás, Mészáros [Mészáros, Tamás (nanomedicina), author] Nanomedicina Kutató és Oktató Központ (SU / FM / I / TMI); Transzlációs Medicina Intézet (SU / FM / I) 2 0.083 false false Author 10064003 /api/author/10064003 Tamás Mészáros (nanomedicina) Mészáros Tamás true 10064003 true Tamás Mészáros true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104128634 /api/authorship/104128634 Petra, Berényi 3 0.083333336 false false Petra Berényi true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104128635 /api/authorship/104128635 Réka, Facskó [Facskó, Réka (elméleti orvostud...), author] Transzlációs Medicina Intézet (SU / FM / I) 4 0.083 false false Author 10083173 /api/author/10083173 Réka Facskó (elméleti orvostudományok) Facskó Réka true true Réka Facskó true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104128636 /api/authorship/104128636 Zsófia, Patkó [Patkó, Zsófia Panna (farmakokinetika, ...), author] Gyakorlati Módszertani és Diagnosztikai Intézet (UM / FHS) 5 0.083 false false Author 10032791 /api/author/10032791 Zsófia Panna Patkó (farmakokinetika, nukleáris medicina, radiológia) Patkó Zsófia Panna DUPLUM true 10032791 true Zsófia Patkó true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104128637 /api/authorship/104128637 Oláh, Csaba [Oláh, Csaba Zsolt (idegsebészet), author] 6 0.083333336 false false Author 10075617 /api/author/10075617 Csaba Zsolt Oláh (idegsebészet) Oláh Csaba Zsolt true true Oláh Csaba true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104128638 /api/authorship/104128638 Adrienne, Nagy 7 0.083333336 false false Adrienne Nagy true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104128639 /api/authorship/104128639 Tamás, Gyula Fülöp 8 0.083333336 false false Tamás Gyula Fülöp true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104128640 /api/authorship/104128640 Kathryn, Anne Glatter 9 0.083333336 false false Kathryn Anne Glatter true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104128641 /api/authorship/104128641 Tamás, Radovits [Radovits, Tamás (kardiológia, érgy...), author] Cardiovascular Center (SU / FM / C) 10 0.083 false false Author 10013969 /api/author/10013969 Tamás Radovits (kardiológia, érgyógyászat) Radovits Tamás true 10013969 true Tamás Radovits true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104128642 /api/authorship/104128642 Béla, Merkely** [Merkely, Béla Péter (Kardiológia), author] Cardiovascular Center (SU / FM / C) 11 0.083 false true Author 10002691 /api/author/10002691 Béla Péter Merkely (Kardiológia) Merkely Béla Péter true 10002691 true Béla Merkely true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104128643 /api/authorship/104128643 János, Szebeni ✉ [Szebeni, János (Klinikai orvostud...), author] Nanomedicina Kutató és Oktató Központ (SU / FM / I / TMI); Elméleti Egészségtudományok Intézete (UM / FHS); Transzlációs Medicina Intézet (SU / FM / I) 12 0.083 false true true Author 10003266 /api/author/10003266 János Szebeni (Klinikai orvostudomány, immunológia, nanomedicina) Szebeni János true 10003266 true János Szebeni true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 21989741 /api/publicationidentifier/21989741 Preprint DOI: 10.1101/2022.10.03.22280227 PlainSource 10006 /api/publicationsource/10006 Preprint DOI PublicationSourceType 10006 /api/publicationsourcetype/10006 Link true true true Preprint DOI Preprint DOI https://doi.org/@@@ true true 10006 true 10.1101/2022.10.03.22280227 https://doi.org/10.1101/2022.10.03.22280227 false true PublicationIdentifier 21989742 /api/publicationidentifier/21989742 Egyéb URL: https://www.researchgate.net/publication/364179819_Role_of_anti-polyethylene_glycol_PEG_antibodies_in_the_allergic_reactions_and_immunogenicity_of_PEG-containing_Covid-19_vaccines PlainSource 40 /api/publicationsource/40 Other URL PublicationSourceType 10006 /api/publicationsourcetype/10006 Link true true true Egyéb URL Other URL @@@ true true 40 true https://www.researchgate.net/publication/364179819_Role_of_anti-polyethylene_glycol_PEG_antibodies_in_the_allergic_reactions_and_immunogenicity_of_PEG-containing_Covid-19_vaccines https://www.researchgate.net/publication/364179819_Role_of_anti-polyethylene_glycol_PEG_antibodies_in_the_allergic_reactions_and_immunogenicity_of_PEG-containing_Covid-19_vaccines false true /api/publication/33209367 Gergely Tibor Kozma et al. Role of anti-polyethylene glycol (PEG) antibodies in the allergic reactions and immunogenicity of PEG-containing Covid-19 vaccines. (2022)<div class="PublicationOther Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10024742"><a href="/gui2/?type=authors&mode=browse&sel=10024742" target="_blank">Gergely Tibor Kozma (<span class="authorship-author-name">Kozma Gergely Tibor</span> <span class="authorAux-mtmt"> Immunológia, Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/Nanomedicina Kutató és Oktató Központ; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064003"><a href="/gui2/?type=authors&mode=browse&sel=10064003" target="_blank">Tamás Mészáros (<span class="authorship-author-name">Mészáros Tamás</span> <span class="authorAux-mtmt"> nanomedicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/Nanomedicina Kutató és Oktató Központ; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Petra Berényi </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10083173"><a href="/gui2/?type=authors&mode=browse&sel=10083173" target="_blank">Réka Facskó (<span class="authorship-author-name">Facskó Réka</span> <span class="authorAux-mtmt"> elméleti orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032791"><a href="/gui2/?type=authors&mode=browse&sel=10032791" target="_blank">Zsófia Patkó (<span class="authorship-author-name">Patkó Zsófia Panna</span> <span class="authorAux-mtmt"> farmakokinetika, nukleáris medicina, radiológia</span>) </a> </span> <span class="author-affil"><span title="University of Miskolc">UM</span>/<span title="Faculty of Health Sciences ">FHS</span>/Gyakorlati Módszertani és Diagnosztikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075617"><a href="/gui2/?type=authors&mode=browse&sel=10075617" target="_blank">Oláh Csaba (<span class="authorship-author-name">Oláh Csaba Zsolt</span> <span class="authorAux-mtmt"> idegsebészet</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Adrienne Nagy </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tamás Gyula Fülöp </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kathryn Anne Glatter </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013969"><a href="/gui2/?type=authors&mode=browse&sel=10013969" target="_blank">Tamás Radovits (<span class="authorship-author-name">Radovits Tamás</span> <span class="authorAux-mtmt"> kardiológia, érgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Béla Merkely^** (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003266"><a href="/gui2/?type=authors&mode=browse&sel=10003266" target="_blank">János Szebeni ✉ (<span class="authorship-author-name">Szebeni János</span> <span class="authorAux-mtmt"> Klinikai orvostudomány, immunológia, nanomedicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/Nanomedicina Kutató és Oktató Központ; <span title="University of Miskolc">UM</span>/<span title="Faculty of Health Sciences ">FHS</span>/Elméleti Egészségtudományok Intézete; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33209367" target="_blank">Role of anti-polyethylene glycol (PEG) antibodies in the allergic reactions and immunogenicity of PEG-containing Covid-19 vaccines</a></div> <div class="description"> </div> <div class="country"> Country: <span class="publishedYear">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1101/2022.10.03.22280227" target="_blank" href="https://doi.org/10.1101/2022.10.03.22280227"> Preprint DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://www.researchgate.net/publication/364179819_Role_of_anti-polyethylene_glycol_PEG_antibodies_in_the_allergic_reactions_and_immunogenicity_of_PEG-containing_Covid-19_vaccines" target="_blank" href="https://www.researchgate.net/publication/364179819_Role_of_anti-polyethylene_glycol_PEG_antibodies_in_the_allergic_reactions_and_immunogenicity_of_PEG-containing_Covid-19_vaccines"> Other URL </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 5</span> | Independent citation: 3 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 4 | Number of citations in Scopus:&nbsp;3 | WoS/Scopus assigned:&nbsp;4 | Number of citations with DOI:&nbsp;4 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33209367&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33209367</span> | <span class="status-data status-ADMIN_APPROVED"> Admin approved </span> Core Citing | <span class="type-subtype">Miscellaneous ( Publication in repository ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Last Modified: 2025.09.08. 09:50 Edit Csajbók (SE_KK_Admin5_CSE, admin) </div> </div></div>