https://m2.mtmt.hu/ hun 2026-09-21 13:38 JournalArticle 33200366 APPROVED true 0 false 2026-08-03T07:22:47.237+0000 2026-01-26T13:11:16.860+0000 2022-10-31T09:38:15.760+0000 true 10071338 Molnár-Taga Márta /api/admin/10071338 Admin true 2026-01-26T13:11:53.405+0000 2026-01-26T13:11:53.405+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Nemeth, Dora Factors influencing the SARS-CoV-2 infection and vaccination induced immune response in rheumatoid arthritis true true /api/journal/10023324 REVIEWED true false 10023324 false 10023324 true 1664-3224 1664-3224 Journal FOREIGN 13 960001 960001 12 2022 <sec>BackgroundTo investigate the factors that have significant impact on the Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) infection and vaccination induced immune response in rheumatoid arthritis (RA).</sec><sec>MethodsSerological response was measured by quantifying anti-SARS-CoV-2 specific antibodies, while the cell-mediated response was measured by a whole-blood test quantifying the interferon (IFN)-γ response to different SARS-CoV-2-specific domains.</sec><sec>ResultsWe prospectively enrolled 109 RA patients and 43 healthy controls. The median time (IQR) between the confirmed infection or the last vaccination dose and the day when samples were taken (“sampling interval”) was 3.67 (2.03, 5.50) months in the RA group. Anti-Spike (anti-S) specific antibodies were detected in 94% of RA patients. Among the investigated patient related variables, age (p<0.004), sampling interval (p<0.001), the brand of the vaccine (p<0.001) and targeted RA therapy (TNF-inhibitor, IL-6 inhibitor, anti-CD20 therapy) had significant effect on the anti-S levels. After covariate adjustment TNF-inhibitor therapy decreased the anti-S antibody concentrations by 80% (p<0.001). The same figures for IL-6 inhibitor and anti-CD20 therapy were 74% (p=0.049) and 97% (p=0.002), respectively. Compared to subjects who were infected but were not vaccinated, the RNA COVID-19 vaccines increased the anti-S antibody levels to 71.1 (mRNA-1273) and 36.0 (BNT162b2) fold (p<0.001). The corresponding figure for the ChAdOx1s vaccine is 18.1(p=0.037). Anti-CCP (anti-cyclic citrullinated peptides) positive patients had 6.28 times (p= 0.00165) higher anti-S levels, than the anti-CCP negative patients. Positive T-cell response was observed in 87% of the healthy volunteer group and in 52% of the RA patient group. Following vaccination or infection it declined significantly (p= 0.044) but more slowly than that of anti-S titer (6%/month versus 25%). Specific T-cell responses were decreased by 65% in patients treated with anti-CD20 therapy (p=0.055).</sec><sec>ConclusionOur study showed that the SARS-CoV-2-specific antibody levels were substantially reduced in RA patients treated with TNF-α-inhibitors (N=51) and IL-6-inhibitor (N=15). In addition, anti-CD20 therapy (N=4) inhibited both SARS-CoV-2-induced humoral and cellular immune responses. Furthermore, the magnitude of humoral and cellular immune response was dependent on the age and decreased over time. The RNA vaccines and ChAdOx1s vaccine effectively increased the level of anti-S antibodies.</sec> Funding 2019650 /api/funding/2019650 false true Funding 2019651 /api/funding/2019651 false true Funding 2019652 /api/funding/2019652 false true Funding 2019653 /api/funding/2019653 false true Funding 2019654 /api/funding/2019654 false true Funding 2019655 /api/funding/2019655 false true true true 2022 true true true false true false GOLD 2026-08-03 true https://doi.org/10.3389/fimmu.2022.960001 15 0 15 13 3 14 15 13 12 15 15 13 13 13 2 0 15 13 15 13 0 1 1 Folyóiratcikk Journal Article 24 14 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 6 6 6 6 2024 0 8 6 8 6 2025 0 1 1 1 1 Q1 false 10015597 false false false 2022-11-07T13:55:24.945+0000 Belgyógyászati és Onkológiai Klinika (SE / AOK / K); Budai Irgalmasrendi Kórház Kht.; Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I); Gyógyszerhatástani Intézet (SE / GYTK); Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K); Reumatológiai és Klinikai Immunológiai Tanszék (SE / AOK / K / BOK); Sportorvostan Tanszék (SE / AOK / K); Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 8 45 8 9 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 104081405 /api/authorship/104081405 1 0.111 true false true Author 10080229 /api/author/10080229 Németh Dóra true true 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true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104081410 /api/authorship/104081410 6 0.11111111 false false false Szabo Zsofia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104081411 /api/authorship/104081411 7 0.11111111 false false false Author 10048660 /api/author/10048660 Rojkovich Bernadette true 10048660 true Rojkovich Bernadett true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104081412 /api/authorship/104081412 8 0.111 false true false Author 10002691 /api/author/10002691 Merkely Béla Péter true 10002691 true Merkely Bela true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104081413 /api/authorship/104081413 9 0.111 false true false Author 10025749 /api/author/10025749 Nagy György true 10025749 true Nagy Gyorgy true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 21966875 /api/publicationidentifier/21966875 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3389/fimmu.2022.960001 https://doi.org/10.3389/fimmu.2022.960001 false true PublicationIdentifier 22002809 /api/publicationidentifier/22002809 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000876724100001 https://www.webofscience.com/wos/woscc/full-record/000876724100001 true true PublicationIdentifier 22001046 /api/publicationidentifier/22001046 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 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long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10080229"><a href="/gui2/?type=authors&mode=browse&sel=10080229" target="_blank">Nemeth Dora ✉ (<span class="authorship-author-name">Németh Dóra</span> <span class="authorAux-mtmt"> reumatológia, klinikai immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Belgyógyászati és Onkológiai Klinika">BOK</span>/Reumatológiai és Klinikai Immunológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013981"><a href="/gui2/?type=authors&mode=browse&sel=10013981" target="_blank">Vago Hajnalka (<span class="authorship-author-name">Vágó Hajnalka</span> <span class="authorAux-mtmt"> Kardiológia, MR</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Sportorvostan Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015597"><a href="/gui2/?type=authors&mode=browse&sel=10015597" target="_blank">Tothfalusi Laszlo (<span class="authorship-author-name">Tóthfalusi László</span> <span class="authorAux-mtmt"> Farmakometria</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10089497"><a href="/gui2/?type=authors&mode=browse&sel=10089497" target="_blank">Ulakcsai Zsuzsanna (<span class="authorship-author-name">Ulakcsai Zsuzsanna</span> <span class="authorAux-mtmt"> aneszteziológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013967"><a href="/gui2/?type=authors&mode=browse&sel=10013967" target="_blank">Becker David (<span class="authorship-author-name">Becker Dávid</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szabo Zsofia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048660"><a href="/gui2/?type=authors&mode=browse&sel=10048660" target="_blank">Rojkovich Bernadett (<span class="authorship-author-name">Rojkovich Bernadette</span> <span class="authorAux-mtmt"> reumatológia</span>) </a> </span> <span class="author-affil">Budai Irgalmasrendi Kórház Kht.</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Merkely Bela<sup>**</sup> (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Sportorvostan Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025749"><a href="/gui2/?type=authors&mode=browse&sel=10025749" target="_blank">Nagy Gyorgy (<span class="authorship-author-name">Nagy György</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Belgyógyászati és Onkológiai Klinika">BOK</span>/Reumatológiai és Klinikai Immunológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33200366" target="_blank">Factors influencing the SARS-CoV-2 infection and vaccination induced immune response in rheumatoid arthritis</a></div> <div> <span class="journal-title">FRONTIERS IN IMMUNOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-3224">1664-3224</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-3224">1664-3224</a>)</span>: <span class="journal-volume">13</span> <span class="page"> Paper 960001. 12 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fimmu.2022.960001" target="_blank" href="https://doi.org/10.3389/fimmu.2022.960001"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000876724100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000876724100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85140575334" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85140575334"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36311767" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36311767&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology and Allergy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 15</span> | Független: 13 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 13 | Scopus jelölt:&nbsp;12 | WoS/Scopus jelölt:&nbsp;15 | DOI jelölt:&nbsp;15 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33200366&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33200366</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="funder"> (2020- 2.1.1-ED-2022-00198) Támogató: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal, (TKP2021-EGA-29), (OTKA K131479) Támogató: OTKA, (2020-1.1.6-JOVO-2021-00013), (RRF-2.3.1-21-2022-00003), (TKP2021-EGA-23) Támogató: Innovációs és Technológiai Minisztérium </div> <div class="lastModified">Utolsó módosítás: 2026.01.26. 14:11 Nagy Regina (SE_AOK_Városmajor_Kardiol_Szívseb_Admin5_NR, admin) </div> </div></div>