https://m2.mtmt.hu/ eng 2026-06-25 10:29 JournalArticle 33197558 VALIDATED true Medical Imaging Centre, Semmelweis University, Budapest, 1082, Hungary Department of Radiology, Faculty of Medicine and Health, Örebro University, Örebro, 702 81, Sweden Export Date: 23 January 2024 Correspondence Address: Tarnoki, D.L.; Medical Imaging Centre, Hungary; email: tarnoki4@gmail.com 0 false 2026-05-22T06:39:34.260+0000 2023-06-16T10:22:42.142+0000 2022-10-28T09:58:59.451+0000 true 10078578 Maár-Sipos Edina /api/admin/10078578 Admin true 2025-02-05T07:55:45.334+0000 2023-06-16T10:22:42.606+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Alijanpourotaghsara, Amirreza Genetic and Environmental Effects on the Development of White Matter Hyperintensities in a Middle Age Twin Population true true /api/journal/10011725 REVIEWED true false 10011725 false 10011725 true 1010-660X 1648-9144 Journal FOREIGN 58 10 1425 1425 11 2022 Introduction: White matter hyperintensities (WMH) indicate white matter brain lesions in magnetic resonance imaging (MRI), which can be used as a marker for brain aging and cerebrovascular and neurodegenerative disorders. Twin studies revealed substantial but not uniform WMH heritability in elderly twins. The objective of our study was to investigate the genetic and environmental components of WMH, as well as their importance in a healthy twin population, utilizing 3T MRI scanners in a middle-aged twin population. Methods: Brain MRI was performed on 120 healthy adult twins from the Hungarian Twin Registry on a 3T scanner (86 monozygotic, MZ and 34 dizygotic, DZ twins; median age 50 ± 26.5 years, 72.5% female and 27.5% male). The count of WMH on FLAIR images was calculated using an automated volumetry pipeline (volBrain) and human processing. The age- and sex-adjusted MZ and DZ intra-pair correlations were determined and the total variance was decomposed into genetic, shared and unique environmental components using structural equation modeling. Results: Age and sex-adjusted MZ intrapair correlations were higher than DZ correlations, indicating moderate genetic influence in each lesion (rMZ = 0.466, rDZ = -0.025 for total count; rMZ = 0.482, rDZ = 0.093 for deep white matter count; rMZ = 0.739, rDZ = 0.39 for infratentorial count; rMZ = 0.573, rDZ = 0.372 for cerebellar count and rMZ = 0.473, rDZ = 0.19 for periventricular count), indicating a moderate heritability (A = 40.3%, A = 45%, A = 72.7% and A = 55.5%and 47.2%, respectively). The rest of the variance was influenced by unique environmental effects (E between 27.3% and 59.7%, respectively). Conclusions: The number of WMH lesions is moderately influenced by genetic effects, particularly in the infratentorial region in middle-aged twins. These results suggest that the distribution of WMH in various brain regions is heterogeneous. Funding 2019935 /api/funding/2019935 false true Funding 2019936 /api/funding/2019936 false true Funding 2019937 /api/funding/2019937 false true Funding 2019938 /api/funding/2019938 false true true 2022 true true true false true false GOLD 2026-05-22 true https://doi.org/10.3390/medicina58101425 3 0 3 1 2 3 3 3 3 3 3 1 1 1 2 0 3 1 3 1 0 3 3 Folyóiratcikk Journal Article 24 3 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 1 0 1 0 2025 0 2 1 2 1 Q2 false false false false 2022-11-08T07:34:49.369+0000 Orvosi Képalkotó Klinika (SE / AOK / K) 12 45 1 13 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 104071402 /api/authorship/104071402 1 0.077 true false false Author 10085938 /api/author/10085938 Alijanpourotaghsara Amirreza true true Alijanpourotaghsara Amirreza true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104071403 /api/authorship/104071403 2 0.077 false false false Author 10086360 /api/author/10086360 Strelnikov David true true Strelnikov David true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104071404 /api/authorship/104071404 3 0.077 false false false Author 10070362 /api/author/10070362 Piroska Márton true true Piroska Marton true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104071405 /api/authorship/104071405 4 0.077 false false false Author 10079757 /api/author/10079757 Szalontai László true true Szalontai Laszlo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104071406 /api/authorship/104071406 5 0.07692308 false false false Forgo Bianka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104071407 /api/authorship/104071407 6 0.077 false false false Author 10070296 /api/author/10070296 Jokkel Zsófia true true Jokkel Zsofia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104071408 /api/authorship/104071408 7 0.077 false false false Author 10089449 /api/author/10089449 Persely Aliz true true Persely Alíz true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104071409 /api/authorship/104071409 8 0.077 false false false Author 10061218 /api/author/10061218 Hernyes Anita true 10061218 true Hernyes Anita true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104071410 /api/authorship/104071410 9 0.077 false false false Author 10017026 /api/author/10017026 Kozák Lajos Rudolf true 10017026 true Kozak Lajos Rudolf true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104071411 /api/authorship/104071411 10 0.077 false false false Author 10049581 /api/author/10049581 Szabó Ádám György true 10049581 true Szabo Adam true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104071412 /api/authorship/104071412 11 0.077 false false false Author 10019530 /api/author/10019530 Maurovich-Horvat Pál true 10019530 true Maurovich-Horvat Pal true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104071413 /api/authorship/104071413 12 0.077 false false false Author 10023716 /api/author/10023716 Tárnoki Ádám Domonkos true 10023716 true Tarnoki Adam Domonkos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104071414 /api/authorship/104071414 13 0.077 false true true Author 10023718 /api/author/10023718 Tárnoki Dávid László true 10023718 true Tarnoki David Laszlo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 21960928 /api/publicationidentifier/21960928 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/medicina58101425 https://doi.org/10.3390/medicina58101425 false true PublicationIdentifier 22002835 /api/publicationidentifier/22002835 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000875130900001 https://www.webofscience.com/wos/woscc/full-record/000875130900001 true true PublicationIdentifier 22002836 /api/publicationidentifier/22002836 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85140764157 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85140764157 true true PublicationIdentifier 21960927 /api/publicationidentifier/21960927 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36295585 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36295585&dopt=Abstract false true Keyword 17542 /api/keyword/17542 true 17542 true Keyword 1001043 /api/keyword/1001043 true 1001043 true Keyword 1062397 /api/keyword/1062397 true 1062397 true Keyword 1501095 /api/keyword/1501095 true true Keyword 1702334 /api/keyword/1702334 true true SjrRating 11310056 /api/sjrrating/11310056 1068 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true Q2 DIRECT true true /api/publication/33197558 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10085938"><a href="/gui2/?type=authors&mode=browse&sel=10085938" target="_blank">Alijanpourotaghsara Amirreza (<span class="authorship-author-name">Alijanpourotaghsara Amirreza</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10086360"><a href="/gui2/?type=authors&mode=browse&sel=10086360" target="_blank">Strelnikov David (<span class="authorship-author-name">Strelnikov David</span> <span class="authorAux-mtmt"> Radiology</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10070362"><a href="/gui2/?type=authors&mode=browse&sel=10070362" target="_blank">Piroska Marton (<span class="authorship-author-name">Piroska Márton</span> <span class="authorAux-mtmt"> Radiológia, Nukleáris Medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10079757"><a href="/gui2/?type=authors&mode=browse&sel=10079757" target="_blank">Szalontai Laszlo (<span class="authorship-author-name">Szalontai László</span> <span class="authorAux-mtmt"> Radiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Forgo Bianka </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10070296"><a href="/gui2/?type=authors&mode=browse&sel=10070296" target="_blank">Jokkel Zsofia (<span class="authorship-author-name">Jokkel Zsófia</span> <span class="authorAux-mtmt"> Radiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10089449"><a href="/gui2/?type=authors&mode=browse&sel=10089449" target="_blank">Persely Alíz (<span class="authorship-author-name">Persely Aliz</span> <span class="authorAux-mtmt"> neurológia, neuroradiológia, ikerkutatás</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061218"><a href="/gui2/?type=authors&mode=browse&sel=10061218" target="_blank">Hernyes Anita (<span class="authorship-author-name">Hernyes Anita</span> <span class="authorAux-mtmt"> radiológia/elméleti orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017026"><a href="/gui2/?type=authors&mode=browse&sel=10017026" target="_blank">Kozak Lajos Rudolf (<span class="authorship-author-name">Kozák Lajos Rudolf</span> <span class="authorAux-mtmt"> Radiológia, Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10049581"><a href="/gui2/?type=authors&mode=browse&sel=10049581" target="_blank">Szabo Adam (<span class="authorship-author-name">Szabó Ádám György</span> <span class="authorAux-mtmt"> radiológia, neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10019530"><a href="/gui2/?type=authors&mode=browse&sel=10019530" target="_blank">Maurovich-Horvat Pal (<span class="authorship-author-name">Maurovich-Horvat Pál</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023716"><a href="/gui2/?type=authors&mode=browse&sel=10023716" target="_blank">Tarnoki Adam Domonkos (<span class="authorship-author-name">Tárnoki Ádám Domonkos</span> <span class="authorAux-mtmt"> radiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023718"><a href="/gui2/?type=authors&mode=browse&sel=10023718" target="_blank">Tarnoki David Laszlo ✉ (<span class="authorship-author-name">Tárnoki Dávid László</span> <span class="authorAux-mtmt"> radiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Orvosi Képalkotó Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33197558" target="_blank">Genetic and Environmental Effects on the Development of White Matter Hyperintensities in a Middle Age Twin Population</a></div> <div> <span class="journal-title">MEDICINA-LITHUANIA</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1010-660X">1010-660X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1648-9144">1648-9144</a>)</span>: <span class="journal-volume">58</span> <span class="journal-issue">10</span> <span class="page"> Paper 1425. 11 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/medicina58101425" target="_blank" href="https://doi.org/10.3390/medicina58101425"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000875130900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000875130900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85140764157" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85140764157"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36295585" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36295585&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 3</span> | Independent citation: 1 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 3 | Number of citations in Scopus:&nbsp;3 | WoS/Scopus assigned:&nbsp;3 | Number of citations with DOI:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33197558&sort=publishedYear,desc&sort=title"> Number of cited publications: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33197558</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (Semmelweis Science and Innovation Fund), (János Bolyai Research Scholarship), (UNKP-20-5), (ÚNKP-21-5) </div> <div class="lastModified">Last Modified: 2023.06.16. 12:22 Tamásné Gere (SE_KK_Admin5_GT, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Medical Imaging Centre, Semmelweis University, Budapest, 1082, Hungary Department of Radiology, Faculty of Medicine and Health, Örebro University, Örebro, 702 81, Sweden Export Date: 23 January 2024 Correspondence Address: Tarnoki, D.L.; Medical Imaging Centre, Hungary; email: tarnoki4@gmail.com</pre> </div></div>