Are NOACs as safe and efficient as VKA regarding thromboembolic prophylaxis and major bleeding in patients with surgical bioprosthesis and atrial fibrillation within 3 months of surgery?

https://m2.mtmt.hu/ hun 2026-05-09 21:45 JournalArticle 33194834 APPROVED true Export Date: 27 October 2022 CODEN: ICTSC Correspondence Address: Magro, P.L.; Department of Cardiothoracic Surgery, Portugal; email: pedromagro@gmail.com 0 false 2023-01-18T12:44:33.047+0000 2022-10-27T12:50:02.927+0000 2022-10-27T12:28:09.706+0000 true 10074913 Sághi-Keszthelyi Anna /api/admin/10074913 Admin Sághi-Keszthelyi Anna (SE_KK_Admin5_SKA, admin) true 2023-01-25T08:40:28.513+0000 false false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Magro, P.L. Are NOACs as safe and efficient as VKA regarding thromboembolic prophylaxis and major bleeding in patients with surgical bioprosthesis and atrial fibrillation within 3 months of surgery? true true /api/journal/10028634 REVIEWED INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY 1569-9293 1569-9285 true false 10028634 false 10028634 true 1569-9293 1569-9285 Journal FOREIGN 34 5 739 743 739 5 2022 A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was: 'Are NOACs as safe and efficient as vitamin K antagonist regarding thromboembolic prophylaxis and major bleeding in patients with surgical bioprosthesis and atrial fibrillation within 3 months of surgery?' Altogether more than 324 papers were found using the reported search, of which 6 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. The RIVER and ENAVLE trials showed non-inferiority of rivaroxaban (regarding mean time free from composite of death, major cardiovascular events or major bleeding at 12 months) and edoxaban (composite of death, clinical thromboembolic events or asymptomatic intracardiac thrombosis; and major bleeding) when compared with vitamin K antagonist. These studies include a low number of patients within 3 months of index surgery and overall low statistical power regarding this particular subgroup of patients. Data derived from lower evidence studies are compatible with the aforementioned findings. The available evidence suggests that non-vitamin K antagonist anticoagulants are as safe and as efficient as vitamin K antagonist regarding thromboembolic prophylaxis and bleeding event rates in patients with surgical bioprosthesis and atrial fibrillation within 3 months of bioprosthesis implantation. However, this evidence is derived from a limited number of studies with important methodological limitations. Expanding non-vitamin K antagonist anticoagulant recommendation to the early postoperative period warrants more confirmatory research. © 2022 The Author(s) 2022. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. 2022 true true true false false GOLD 2023-01-18 false http://icvts.oxfordjournals.org/ 0 0 0 0 0 0 0 0 0 0 0 0 1 1 Q2 false false false false 2023-01-25T13:50:02.791+0000 3 30 0 2 0 false Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 104050859 /api/authorship/104050859 Magro, P.L. ✉ 1 0.5 true false true Magro P.L. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 104050860 /api/authorship/104050860 Sousa-Uva, M. 2 0.5 false true false Sousa-Uva M. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 21953331 /api/publicationidentifier/21953331 DOI: 10.1093/icvts/ivab363 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1093/icvts/ivab363 https://doi.org/10.1093/icvts/ivab363 false true PublicationIdentifier 21953332 /api/publicationidentifier/21953332 WoS: 000756715000001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/WOS:@@@ true true 1 true IDENTICAL 000756715000001 https://www.webofscience.com/wos/woscc/full-record/WOS:000756715000001 false true PublicationIdentifier 21953330 /api/publicationidentifier/21953330 Scopus: 85129998037 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85129998037 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85129998037 false true PublicationIdentifier 22866497 /api/publicationidentifier/22866497 PubMed: 34977926 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 34977926 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34977926&dopt=Abstract false true Keyword 52 /api/keyword/52 Adult true 52 true Keyword 61 /api/keyword/61 Middle Aged true 61 true Keyword 65 /api/keyword/65 Humans true 65 true Keyword 491 /api/keyword/491 HEMORRHAGE true 491 true Keyword 1699 /api/keyword/1699 ARTICLE true 1699 true Keyword 2591 /api/keyword/2591 MORTALITY true 2591 true Keyword 3122 /api/keyword/3122 human true 3122 true Keyword 5785 /api/keyword/5785 cerebrovascular accident true 5785 true Keyword 5792 /api/keyword/5792 surgical technique true 5792 true Keyword 5864 /api/keyword/5864 case report true 5864 true Keyword 5883 /api/keyword/5883 clinical article true 5883 true Keyword 6590 /api/keyword/6590 oral drug administration true 6590 true Keyword 6889 /api/keyword/6889 Administration, Oral true 6889 true Keyword 11207 /api/keyword/11207 Postoperative Period true 11207 true Keyword 14235 /api/keyword/14235 cardiovascular disease true 14235 true Keyword 14299 /api/keyword/14299 drug safety true 14299 true Keyword 14300 /api/keyword/14300 drug efficacy true 14300 true Keyword 17441 /api/keyword/17441 stroke true 17441 true Keyword 18276 /api/keyword/18276 WARFARIN true 18276 true Keyword 1006743 /api/keyword/1006743 Drug Monitoring true 1006743 true Keyword 1011371 /api/keyword/1011371 drug administration route true 1011371 true Keyword 1012071 /api/keyword/1012071 Complication true 1012071 true Keyword 1016421 /api/keyword/1016421 bleeding true 1016421 true Keyword 1016421 /api/keyword/1016421 bleeding true 1016421 true Keyword 1020053 /api/keyword/1020053 thromboembolism true 1020053 true Keyword 1020053 /api/keyword/1020053 thromboembolism true 1020053 true Keyword 1020053 /api/keyword/1020053 thromboembolism true 1020053 true Keyword 1034506 /api/keyword/1034506 anticoagulant agent true 1034506 true Keyword 1034506 /api/keyword/1034506 anticoagulant agent true 1034506 true Keyword 1034507 /api/keyword/1034507 Anticoagulation true 1034507 true Keyword 1036166 /api/keyword/1036166 Fibrinolytic Agents true 1036166 true Keyword 1036167 /api/keyword/1036167 fibrinolytic agent true 1036167 true Keyword 1036242 /api/keyword/1036242 Anticoagulants true 1036242 true Keyword 1036358 /api/keyword/1036358 Clinical outcome true 1036358 true Keyword 1047310 /api/keyword/1047310 vitamin K group true 1047310 true Keyword 1076090 /api/keyword/1076090 heart valve replacement true 1076090 true Keyword 1099402 /api/keyword/1099402 Bioprosthesis true 1099402 true Keyword 1099402 /api/keyword/1099402 Bioprosthesis true 1099402 true Keyword 1099402 /api/keyword/1099402 Bioprosthesis true 1099402 true Keyword 1101336 /api/keyword/1101336 Atrial Fibrillation true 1101336 true Keyword 1101336 /api/keyword/1101336 Atrial Fibrillation true 1101336 true Keyword 1101336 /api/keyword/1101336 Atrial Fibrillation true 1101336 true Keyword 1113248 /api/keyword/1113248 antivitamin K true 1113248 true Keyword 1131167 /api/keyword/1131167 rivaroxaban true 1131167 true Keyword 1141842 /api/keyword/1141842 vitamin K true 1141842 true Keyword 1404939 /api/keyword/1404939 edoxaban true 1404939 true Keyword 1510956 /api/keyword/1510956 intracardiac thrombosis true true Keyword 1641290 /api/keyword/1641290 DOAC true true Keyword 2625436 /api/keyword/2625436 Non-vitamin K antagonist anticoagulant true true SjrRating 11319028 /api/sjrrating/11319028 sjr:Q2 (2022) Scopus - Surgery INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY 1569-9293 1569-9285 191 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2746 /api/classificationexternal/2746 Scopus - Surgery true 2746 true Q2 FROM_LAST_YEAR true true Reference 35105059 /api/reference/35105059 1. Dunning, J, Prendergast, B, Mackway, JK., Towards evidence-based medicine in cardiothoracic surgery: best BETS (2003) Interact CardioVasc Thorac Surg, 2, p. 4059 1 false true Reference 35105060 /api/reference/35105060 2. Guimar~aes, PO, Pokorney, SD, Lopes, RD, Wojdyla, DM, Gersh, BJ, Giczewska, A, Efficacy and safety of apixaban vs warfarin in patients with atrial fibrillation and prior bioprosthetic valve replacement or valve repair: insights from the ARISTOTLE trial (2019) Clin Cardiol, 42, p. 56871 2 false true Reference 35105061 /api/reference/35105061 3. Carnicelli, AP, De Caterina, R, Halperin, JL, Renda, G, Ruff, CT, Trevisan, M, Edoxaban for the prevention of thromboembolism in patients with atrial fibrillation and bioprosthetic valves (2017) Circulation, 135, p. 12735 3 false true Reference 35105062 /api/reference/35105062 4. Guimar~aes, HP, Lopes, RD, de Barros E Silva, PGM, Liporace, IL, Sampaio, RO, Tarasoutchi, F, Hoffmann-Filho, CR, RIVER Trial Investigators. Rivaroxaban in patients with atrial fibrillation and a bioprosthetic mitral valve (2020) N Engl J Med, 383, p. 211726 4 false true Reference 35105063 /api/reference/35105063 5. Shim, CY, Seo, J, Kim, YJ, Lee, SHD, Caterina, R, Lee, S, Hong, GR, Efficacy and safety of edoxaban in patients early after surgical bioprosthetic valve implantation or valve repair: A randomized clinical trial (2021) J Thorac Cardiovasc Surg, (21). , S0022-5223 00228-2 5 false true Reference 35105064 /api/reference/35105064 6. Pasciolla, S, Zizza, LF, Le, T, Wright, K., Comparison of the efficacy and safety of direct oral anticoagulants and warfarin after bioprosthetic valve replacements (2020) Clin Drug Investig, 40, p. 83945 6 false true Reference 35105065 /api/reference/35105065 7. 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(2022) INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY 1569-9293 1569-9285 34 5 739-743<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Magro P.L. ✉ </span> ;    <span class="author-name" >Sousa-Uva M. </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33194834" target="_blank">Are NOACs as safe and efficient as VKA regarding thromboembolic prophylaxis and major bleeding in patients with surgical bioprosthesis and atrial fibrillation within 3 months of surgery?</a></div> <div> <span class="journal-title">INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1569-9293">1569-9293</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1569-9285">1569-9285</a>)</span>: <span class="journal-volume">34</span> <span class="journal-issue">5</span> <span class="page"> pp 739-743 </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1093/icvts/ivab363" target="_blank" href="https://doi.org/10.1093/icvts/ivab363"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000756715000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/WOS:000756715000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85129998037" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85129998037"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34977926" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34977926&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33194834&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33194834</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Utolsó módosítás: 2022.10.27. 14:50 Sághi-Keszthelyi Anna (SE_KK_Admin5_SKA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Export Date: 27 October 2022 CODEN: ICTSC Correspondence Address: Magro, P.L.; Department of Cardiothoracic Surgery, Portugal; email: pedromagro@gmail.com</pre> </div></div>