https://m2.mtmt.hu/ eng 2026-10-24 11:39 JournalArticle 33186836 APPROVED true Department of Neurosurgery, Semmelweis University, Budapest, Hungary National Institute of Mental Health, Neurology and Neurosurgery, Budapest, Hungary Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary Department of Biological Physics, Eötvös Loránd University, Budapest, Hungary Health Services Management Training Center, Semmelweis University, Budapest, Hungary MTA-ELTE Statistical and Biological Physics Research Group, Budapest, Hungary Cited By :1 Export Date: 10 May 2024 CODEN: CLIOE Correspondence Address: Mezei, T.; Department of Neurosurgery, Amerikai út 57, Hungary; email: mezei.tamas@semmelweis-univ.hu 0 false 2026-10-22T20:41:49.512+0000 2026-06-01T12:19:08.686+0000 2022-10-24T05:25:52.415+0000 true 10078148 Havas Petra /api/admin/10078148 Admin true 2026-06-01T12:19:09.038+0000 2026-06-01T12:19:09.038+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Mezei, T A Novel Prognostication System for Spinal Metastasis Patients Based on Network Science and Correlation Analysis. true true /api/journal/33433 REVIEWED true false 33433 false 33433 true 0936-6555 1433-2981 Journal FOREIGN 35 1 e20 e29 e20 10 2023 During the progress of oncological diseases, there is an increased probability that spinal metastases may develop, requiring personalised treatment options. Risk calculator systems aim to provide assistance in the therapeutic decision-making process by estimating survival chances. The predictive ability of such calculators can be improved, thereby optimising the choice of personalised therapy. The aim of this research was to create a new risk assessment system and show a method with which other centres can develop their own local score.We created a database by retrospectively processing 454 patients. The prognostic factors were selected via a network science-based correlation analysis that maximises Uno's C-index, keeping only a small number of predictors. To validate the new system, we calculated the D-statistic, the Integrated Discrimination Index, made a five-fold cross-validation and also calculated the integrated time-dependent Brier score.As a result of multivariate Cox analysis, we found five independent prognostic factors suitable for the design of the risk calculator. This new system has a better predictive ability compared with six other well-known systems with an average C-index of 0.706 at 10 years (95% confidence interval 0.679-0.733).An accurate estimation of the life expectancy of cancer patients is essential for the implementation of personalised medicine. The training performance of our system is encouraging, indicating the benefit of a network science-based visualisation step. We believe that in order to further improve the prediction ability, it is necessary to systematise previously 'unknown' factors (e.g. radiological morphology). Funding 2019688 /api/funding/2019688 false true Funding 2021220 /api/funding/2021220 false true true 2022 true true true false true false GOLD 2026-10-22 true https://doi.org/10.1016/j.clon.2022.09.054 8 0 7 5 3 7 8 6 7 7 7 5 5 5 3 0 8 5 7 5 0 4 4 Folyóiratcikk Journal Article 24 6 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 1 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 1 1 1 2024 0 1 1 1 1 2025 0 4 2 4 2 2026 0 2 1 2 1 Q1 false 10011382,10063651 false false false 2023-01-22T06:25:58.881+0000 Amerikai úti Ideggyógyászati és Idegsebészeti I... (OMIII); Belgyógyászati és Hematológiai Klinika (SE / AOK / K); Egészségügyi Menedzserképző Központ (SE / EKK); Idegsebészeti Tanszék (SE / AOK / K / INK); MTA-ELTE Statisztikus és Biológiai Fizika Kutat... 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<span title="Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet">OMIII</span>/Institute of Neurology and Neurosurgery (Amerikai street)</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023835"><a href="/gui2/?type=authors&mode=browse&sel=10023835" target="_blank">Horváth A (<span class="authorship-author-name">Horváth Anna</span> <span class="authorAux-mtmt"> belgyógyászat; immunológia; onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Belgyógyászati és Hematológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10077790"><a href="/gui2/?type=authors&mode=browse&sel=10077790" target="_blank">Nagy Z (<span class="authorship-author-name">Nagy Zoltán</span> <span class="authorAux-mtmt"> idegsebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Neurosurgery; <span title="Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet">OMIII</span>/Institute of Neurology and Neurosurgery (Amerikai street)</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061714"><a href="/gui2/?type=authors&mode=browse&sel=10061714" target="_blank">Czigléczki G (<span class="authorship-author-name">Czigléczki Gábor</span> <span class="authorAux-mtmt"> Idegsebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Neurosurgery; <span title="Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet">OMIII</span>/Institute of Neurology and Neurosurgery (Amerikai street)</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011382"><a href="/gui2/?type=authors&mode=browse&sel=10011382" target="_blank">Banczerowski P (<span class="authorship-author-name">Banczerowski Péter</span> <span class="authorAux-mtmt"> Idegsebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Neurosurgery; <span title="Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet">OMIII</span>/Institute of Neurology and Neurosurgery (Amerikai street)</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10083423"><a href="/gui2/?type=authors&mode=browse&sel=10083423" target="_blank">Báskay J (<span class="authorship-author-name">Báskay János</span> <span class="authorAux-mtmt"> gépi tanulás, hálózatok, túlélés analízis</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Department of Hygienic Service">DHS</span>/Egészségügyi Menedzserképző Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010935"><a href="/gui2/?type=authors&mode=browse&sel=10010935" target="_blank">Pollner P (<span class="authorship-author-name">Pollner Péter</span> <span class="authorAux-mtmt"> Elméleti és matematikai fizika</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Physics">Inst_Phys</span>/MTA-ELTE Statistical and Biological Physics Research Group; <span title="Semmelweis University">SU</span>/<span title="Department of Hygienic Service">DHS</span>/Egészségügyi Menedzserképző Központ</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33186836" target="_blank">A Novel Prognostication System for Spinal Metastasis Patients Based on Network Science and Correlation Analysis.</a></div> <div> <span class="journal-title">CLINICAL ONCOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0936-6555">0936-6555</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1433-2981">1433-2981</a>)</span>: <span class="journal-volume">35</span> <span class="journal-issue">1</span> <span class="page"> pp e20-e29 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1016/j.clon.2022.09.054" target="_blank" href="https://doi.org/10.1016/j.clon.2022.09.054"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000943854700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000943854700001"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="113504" target="_blank" href="https://edit.elte.hu/handle/10831/113504"> EDIT </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85140265917" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85140265917"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36272862" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36272862&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Radiology, Nuclear Medicine and Imaging&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Oncology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 8</span> | Independent citation: 5 | Self citation: 3 | Unknown citation: 0 | Number of citations in WoS: 6 | Number of citations in Scopus:&nbsp;7 | WoS/Scopus assigned:&nbsp;7 | Number of citations with DOI:&nbsp;8 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33186836&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33186836</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (K128780) Funder: NR-DIO, Egészségbiztonság Nemzeti Laboratórium(RRF-2.3.1-21-2022-00006) Funder: NRDIO </div> <div class="lastModified">Last Modified: 2026.06.01. 14:19 Petra Gabriella Havas (SE_KK_Idegsebeszet_Admin5_HP, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Neurosurgery, Semmelweis University, Budapest, Hungary National Institute of Mental Health, Neurology and Neurosurgery, Budapest, Hungary Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary Department of Biological Physics, Eötvös Loránd University, Budapest, Hungary ...</pre> </div></div>