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Although international business scholars have acknowledged the importance of knowledge distance, the research question is under-explored. Based on the distance approach, this study provides a theoretical foundation for knowledge distance and empirically examines its impact on the innovation performance of multinational enterprises engaging in cross-border acquisitions. Furthermore, we investigated whether internationalization breadth and depth moderate knowledge distance-innovation performance. We examined Chinese-listed firms that made international acquisitions from 2010 to 2016 and found a negative relationship between knowledge distance and innovation performance. We also discovered that internationalization breadth and depth moderate the negative relationship between knowledge distance and innovation performance. 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