https://m2.mtmt.hu/ eng 2026-04-19 03:37 JournalArticle 33175344 APPROVED true Cited By :2 Export Date: 21 October 2022 CODEN: JFQUD Correspondence Address: Zhou, H.; School of Medicine, Zhengjiang, Jiangsu, China; email: hongzhou0123@163.com 0 false 2025-11-04T04:23:27.064+0000 2022-10-21T09:54:17.144+0000 2022-10-21T09:53:27.277+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin Márta Molnár-Taga (SE 4-es admin) true 10062250 2025-09-01T18:13:10.943+0000 2025-09-01T18:13:10.943+0000 false false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Sheng, L. true true /api/journal/2499 REVIEWED JOURNAL OF FOOD QUALITY 0146-9428 1745-4557 true false 2499 false 2499 true 0146-9428 1745-4557 Journal FOREIGN 2021 1210089 1210089 2021 Objective. The gut microbiota, as the critical mediator of the gut-brain axis, can produce and transport neuroactive substances, thus playing a significant role in the pathogenesis of depression. Although regular physical exercise is an important nondrug antidepressant, its specific effector mechanism is still unclear. Methods. Rats were randomly divided into four different groups (n = 10 for each group) as follows: normal group (G1), depression group (G2), fluoxetine treatment group (G3), and regular exercise treatment group (G4). All rats underwent forced swimming tests, tail suspension tests, open field tests, and elevated plus-maze tests to detect behavioristics. Then, corticosterone levels were detected by ELISA. Additionally, taxonomic analysis of the gut microbiota in all rats was performed after they were exercised regularly for 60 days. Results. Compared with the G1 group, the rats in the G2 group showed significant depression-like behaviors, with increased serum corticosterone levels. The proportions of Bacteroides, Actinomycetes, Proteobacteria, Saccharomyces, and Cyanobacteria in rats of the G2 group were lower than those in the G1 group, while the proportions of Firmicutes, Tenicotte, Deferrobacteria, and Fusobacteria were increased. Furthermore, after regular exercise treatment, the gut microbiota of rats was effectively improved, almost returning to the level of the G1 group, and depressive behavior and corticosterone levels were also restored, which was almost the same as the effect of fluoxetine treatment. Conclusion. Regular physical exercise could alleviate depressive-like behaviors by modulating the species and function of the gut microbiota. © 2021 Liangju Sheng et al. 2022 true true true false false NONE 2025-11-04 false 0 0 0 0 0 0 0 0 0 0 0 0 1 1 Q2 false false false false 2023-01-19T10:54:17.026+0000 9 30 0 5 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 103933848 /api/authorship/103933848 Sheng, L. 1 0.2 true false false Sheng L. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 103933849 /api/authorship/103933849 Wang, Y. 2 0.2 false false false Wang Y. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 103933850 /api/authorship/103933850 Jiang, A. 3 0.2 false false false Jiang A. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 103933851 /api/authorship/103933851 Zhou, Y. 4 0.2 false false false Zhou Y. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 103933852 /api/authorship/103933852 Zhou, H. ✉ 5 0.2 false true true Zhou H. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 21908912 /api/publicationidentifier/21908912 DOI: 10.1155/2021/1210089 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1155/2021/1210089 https://doi.org/10.1155/2021/1210089 false true PublicationIdentifier 21908913 /api/publicationidentifier/21908913 WoS: 000709691500001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000709691500001 https://www.webofscience.com/wos/woscc/full-record/000709691500001 false true PublicationIdentifier 21908911 /api/publicationidentifier/21908911 Scopus: 85117391625 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85117391625 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85117391625 false true Keyword 1547 /api/keyword/1547 RATS true 1547 true Keyword 2224 /api/keyword/2224 BACTERIA true 2224 true Keyword 11933 /api/keyword/11933 PHYSICAL EXERCISE true 11933 true Keyword 11953 /api/keyword/11953 bacteroides true 11953 true Keyword 17796 /api/keyword/17796 fluoxetine true 17796 true Keyword 1004633 /api/keyword/1004633 PROTEOBACTERIA true 1004633 true Keyword 1021453 /api/keyword/1021453 Elevated plus maze true 1021453 true Keyword 1047398 /api/keyword/1047398 Sports true 1047398 true Keyword 1065769 /api/keyword/1065769 open field test true 1065769 true Keyword 1142286 /api/keyword/1142286 gut microbiota true 1142286 true Keyword 2041452 /api/keyword/2041452 neuroactive substances true true Keyword 2548687 /api/keyword/2548687 Treatment group true true Keyword 2761928 /api/keyword/2761928 Suspension test true true SjrRating 11187401 /api/sjrrating/11187401 sjr:Q2 (2021) Scopus - Food Science JOURNAL OF FOOD QUALITY 0146-9428 1745-4557 114 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1106 /api/classificationexternal/1106 Scopus - Food Science true 1106 true Q2 DIRECT true true Reference 34900964 /api/reference/34900964 1. Ménard, C., Hodes, G.E., Russo, S.J., Pathogenesis of depression: Insights from human and rodent studies (2016) Neuroscience, 321, pp. 138-162. , 2-s2.0-84930792715 1 false true Reference 34900965 /api/reference/34900965 2. Mayer, E.A., Tillisch, K., Gupta, A., Gut/brain axis and the microbiota (2015) Journal of Clinical Investigation, 125 (3), pp. 926-938. , 2-s2.0-84924085783 2 false true Reference 34900966 /api/reference/34900966 3. Boem, F., Amedei, A., Healthy axis: Towards an integrated view of the gut-brain health (2019) World Journal of Gastroenterology, 25 (29), pp. 3838-3841. , 2-s2.0-85071282494 3 false true Reference 34900967 /api/reference/34900967 4. López-Torres Hidalgo, J., Effectiveness of physical exercise in the treatment of depression in older adults as an alternative to antidepressant drugs in primary care (2019) BMC Psychiatry, 19 (1), p. 21. , 2-s2.0-85059967569 4 false true Reference 34900968 /api/reference/34900968 5. Zheng, P., Zeng, B., Zhou, C., Liu, M., Fang, Z., Xu, X., Zeng, L., Xie, P., Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism (2016) Molecular Psychiatry, 21 (6), pp. 786-796. , 2-s2.0-84963547235 5 false true Reference 34900969 /api/reference/34900969 6. Kelly, J.R., Borre, Y., Brien C, O.'., Patterson, E., El Aidy, S., Deane, J., Kennedy, P.J., Dinan, T.G., Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat (2016) Journal of Psychiatric Research, 82, pp. 109-118. , 2-s2.0-84979955472 6 false true Reference 34900970 /api/reference/34900970 7. Chevalier, G., Siopi, E., Guenin-Macé, L., Pascal, M., Laval, T., Rifflet, A., Boneca, I.G., Lledo, P.-M., Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system (2020) Nature Communications, 11 (1), p. 6363 7 false true Reference 34900971 /api/reference/34900971 8. Schuch, F.B., Vancampfort, D., Richards, J., Rosenbaum, S., Ward, P.B., Stubbs, B., Exercise as a treatment for depression: A meta-analysis adjusting for publication bias (2016) Journal of Psychiatric Research, 77, pp. 42-51. , 2-s2.0-84960338278 8 false true Reference 34900972 /api/reference/34900972 9. Gujral, S., Aizenstein, H., Reynolds, C.F., Butters, M.A., Erickson, K.I., Exercise effects on depression: Possible neural mechanisms (2017) General Hospital Psychiatry, 49, pp. 2-10. , 2-s2.0-85044383624 9 false true Reference 34900973 /api/reference/34900973 10. Sierakowiak, A., Mattsson, A., Gómez-Galán, M., Feminía, T., Graae, L., Aski, S.N., Damberg, P., Aberg, E., Hippocampal morphology in a rat model of depression: The effects of physical activity (2015) The Open Neuroimaging Journal, 9 (1), pp. 1-6 10 false true Reference 34900974 /api/reference/34900974 11. Holzer, P., Farzi, A., Neuropeptides and the microbiota-gut-brain Axis (2014) Advances in Experimental Medicine & Biology, 817, pp. 195-219. , 2-s2.0-84938379194 11 false true Reference 34900975 /api/reference/34900975 12. Mörkl, S., Butler, M.I., Holl, A., Cryan, J.F., Dinan, T.G., Probiotics and the microbiota-gut-brain Axis: Focus on psychiatry (2020) Current Nutrition Reports, 9 (3), pp. 171-182 12 false true Reference 34900976 /api/reference/34900976 13. Sanchez-Ramos, J., Song, S., Sava, V., Catlow, B., Lin, X., Mori, T., Cao, C., Arendash, G.W., Granulocyte colony stimulating factor decreases brain amyloid burden and reverses cognitive impairment in Alzheimer's mice (2009) Neuroscience, 163 (1), pp. 55-72. , 2-s2.0-68349127365 13 false true Reference 34900977 /api/reference/34900977 14. Ridgel, A.L., Walter, B.L., Tatsuoka, C., Walter, E.M., Colón-Zimmermann, K., Welter, E., Sajatovic, M., Enhanced Exercise Therapy in Parkinson's disease: A comparative effectiveness trial (2016) Journal of Science and Medicine in Sport, 19 (1), pp. 12-17. , 2-s2.0-84948072742 14 false true Reference 34900978 /api/reference/34900978 15. Tye, K.M., Mirzabekov, J.J., Warden, M.R., Ferenczi, E.A., Tsai, H.-C., Finkelstein, J., Kim, S.-Y., Deisseroth, K., Dopamine neurons modulate neural encoding and expression of depression-related behaviour (2013) Nature, 493 (7433), pp. 537-541. , 2-s2.0-84872937372 15 false true Reference 34900979 /api/reference/34900979 16. McNeal, N., Appleton, K.M., Johnson, A.K., Scotti, M.-A.L., Wardwell, J., Murphy, R., Bishop, C., Grippo, A.J., The protective effects of social bonding on behavioral and pituitary-adrenal axis reactivity to chronic mild stress in prairie voles (2017) Stress: The International Journal on the Biology of Stress, 20 (2), pp. 175-182. , 2-s2.0-85014555442 16 false true Reference 34900980 /api/reference/34900980 17. Wang, M., Dong, W., Wang, R., Xu, X., Wu, Y., Sun, G., Sun, X., Gastrodiae rhizoma water extract ameliorates hypothalamic-pituitary-adrenal Axis hyperactivity and inflammation induced by chronic unpredictable mild stress in rats (2020) BioMed Research International, 2020, p. 7. , 8374614 17 false true Reference 34900981 /api/reference/34900981 18. Zhang, C., Zhang, Y.-P., Li, Y.-Y., Liu, B.-P., Wang, H.-Y., Li, K.-W., Zhao, S., Song, C., Minocycline ameliorates depressive behaviors and neuro-immune dysfunction induced by chronic unpredictable mild stress in the rat (2019) Behavioural Brain Research, 356, pp. 348-357. , 2-s2.0-85053483796 18 false true Reference 34900982 /api/reference/34900982 19. Lee, H., Ohno, M., Ohta, S., Mikami, T., Regular moderate or intense exercise prevents depression-like behavior without change of hippocampal tryptophan content in chronically tryptophan-deficient and stressed mice (2013) PLoS One, 8 (7). , e66996 2-s2.0-84879819257 19 false true Reference 34900983 /api/reference/34900983 20. Micheli, L., Ceccarelli, M., D'Andrea, G., Tirone, F., Depression and adult neurogenesis: Positive effects of the antidepressant fluoxetine and of physical exercise (2018) Brain Research Bulletin, 143, pp. 181-193. , 2-s2.0-85054468119 20 false true Reference 34900984 /api/reference/34900984 21. Mueller, P.J., Mischel, N.A., Selective enhancement of glutamate-mediated pressor responses after GABAA receptor blockade in the RVLM of sedentary versus spontaneous wheel running rats (2012) Frontiers in Physiology, 3, p. 447. , 2-s2.0-84870913307 21 false true Reference 34900985 /api/reference/34900985 22. Lapmanee, S., Charoenphandhu, J., Teerapornpuntakit, J., Krishnamra, N., Charoenphandhu, N., Agomelatine, venlafaxine, and running exercise effectively prevent anxiety- And depression-like behaviors and memory impairment in restraint stressed rats (2017) PLoS One, 12 (11). , e0187671 2-s2.0-85032832871 22 false true Reference 34900986 /api/reference/34900986 23. Yang, C., Zhang, Z., Ma, J., Effects of different spectral energy distributions on physiological behavior and hormone levels in depression[J] (2018) Iranian Journal of Public Health, 47 (3), pp. 373-381 23 false true Reference 34900987 /api/reference/34900987 24. Toups, M., Carmody, T., Greer, T., Rethorst, C., Grannemann, B., Trivedi, M.H., Exercise is an effective treatment for positive valence symptoms in major depression (2017) Journal of Affective Disorders, 209, pp. 188-194. , 2-s2.0-85003876186 24 false true Reference 34900988 /api/reference/34900988 25. Krogh, J., Hjorthøj, C., Speyer, H., Gluud, C., Nordentoft, M., Exercise for patients with major depression: A systematic review with meta-analysis and trial sequential analysis (2017) BMJ Open, 7 (9). , e014820 2-s2.0-85035018885 25 false true Reference 34900989 /api/reference/34900989 26. Tang, M., Huang, H., Li, S., Zhou, M., Liu, Z., Huang, R., Liao, W., Zhou, J., Hippocampal proteomic changes of susceptibility and resilience to depression or anxiety in a rat model of chronic mild stress (2019) Translational Psychiatry, 9 (1), p. 260. , 2-s2.0-85073532428 26 false true Reference 34900990 /api/reference/34900990 27. Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Ruan, B., Altered fecal microbiota composition in patients with major depressive disorder (2015) Brain, Behavior, and Immunity, 48, pp. 186-194. , 2-s2.0-84942984411 27 false true Reference 34900991 /api/reference/34900991 28. Jianguo, L., Xueyang, J., Cui, W., Changxin, W., Xuemei, Q., Correction: Altered gut metabolome contributes to depression-like behaviors in rats exposed to chronic unpredictable mild stress (2019) Translational Psychiatry, 9 (1), p. 275 28 false true Reference 34900992 /api/reference/34900992 29. Li, B., Guo, K., Zeng, L., Zeng, B., Huo, R., Luo, Y., Wang, H., Xie, P., Metabolite identification in fecal microbiota transplantation mouse livers and combined proteomics with chronic unpredictive mild stress mouse livers (2018) Translational Psychiatry, 8 (1), p. 34. , 2-s2.0-85041457311 29 false true Reference 34900993 /api/reference/34900993 30. Kuti, D., Winkler, Z., Horváth, K., Juhász, B., Paholcsek, M., Stágel, A., Gulyás, G., Kovács, K.J., Gastrointestinal (non-systemic) antibiotic rifaximin differentially affects chronic stress-induced changes in colon microbiome and gut permeability without effect on behavior (2020) Brain, Behavior, and Immunity, 84, pp. 218-228 30 false true Reference 34900994 /api/reference/34900994 31. Grochowska, M., Wojnar, M., Radkowski, M., The gut microbiota in neuropsychiatric disorders (2018) Acta Neurobiologiae Experimentalis, 78 (2), pp. 69-81 31 false true Reference 34900995 /api/reference/34900995 32. Petersen, A.M., Pedersen, B.K., The anti-inflammatory effect of exercise (1985) Journal of Applied Physiology, 98 (4), pp. 1154-1162 32 false true /api/publication/33175344 Sheng L. et al. Effect of Regular Physical Exercise on Gut Microbiota and Depressive Behaviors in Rats. (2021) JOURNAL OF FOOD QUALITY 0146-9428 1745-4557 2021<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Sheng L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wang Y. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jiang A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zhou Y. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zhou H. ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33175344" target="_blank">Effect of Regular Physical Exercise on Gut Microbiota and Depressive Behaviors in Rats</a></div> <div> <span class="journal-title">JOURNAL OF FOOD QUALITY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0146-9428">0146-9428</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1745-4557">1745-4557</a>)</span>: <span class="journal-volume">2021</span> <span class="page"> Paper 1210089. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1155/2021/1210089" target="_blank" href="https://doi.org/10.1155/2021/1210089"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000709691500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000709691500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85117391625" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85117391625"> Scopus </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33175344&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33175344</span> | <span class="status-data status-APPROVED"> Published </span> Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Last Modified: 2022.10.21. 11:54 Márta Molnár-Taga (SE 4-es admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Cited By :2 Export Date: 21 October 2022 CODEN: JFQUD Correspondence Address: Zhou, H.; School of Medicine, Zhengjiang, Jiangsu, China; email: hongzhou0123@163.com</pre> </div></div>