Pseudoxanthoma elasticum and Fabry disease are rare multi-systemic diseases with characteristic
skin manifestations. Their rarity and complicated diagnostic process causes disability,
decreased quality of life, and increased medical costs for the patients before the
diagnosis. Therefore, a new non-invasive diagnostic approach will be developed using
multispectral imaging to analyze images of Pseudoxanthoma elasticum skin manifestations
and angiokeratomas which are characteristic of Fabry disease. For image acquisition
an imaging prototype will be used utilizing 526 nm, 663 nm and 964 nm multispectral
LEDs for diffuse reflectance imaging and 405 nm LEDs for autofluorescence excitation,
as well as Nuance camera with spectral range 450 - 950 nm. Spectral reflectance and
autofluorescence images will be analyzed to determine informative/efficient parameters
suitable for identification and diagnostics of rare diseases.
