https://m2.mtmt.hu/ hun 2026-09-21 17:54 JournalArticle 33163272 VALIDATED true * Megosztott szerzőség 0 false 2026-07-03T14:23:00.878+0000 2025-07-01T19:17:10.805+0000 2022-10-19T08:17:22.170+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2025-07-01T19:17:11.003+0000 2025-07-01T19:17:11.003+0000 2023-09-02T14:03:27.620+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kocsmár, Ildikó Addition of Chromosome 17 Polysomy and HER2 Amplification Status Improves the Accuracy of Clinicopathological Factor-Based Progression Risk Stratification and Tumor Grading of Non-Muscle-Invasive Bladder Cancer. true true /api/journal/10032813 REVIEWED true false 10032813 false 10032813 true 2072-6694 Journal FOREIGN 14 19 4570 4570 19 2022 Progression of non-muscle-invasive bladder cancer (NMIBC) to muscle-invasive disease (MIBC) significantly worsens life expectancy. Its risk can be assessed by clinicopathological factors according to international guidelines. However, additional molecular markers are needed to refine and improve the prediction. Therefore, in the present study, we aimed to predict the progression of NMIBCs to MIBC by assessing p53 expression, polysomy of chromosome 17 (Chr17) and HER2 status in the tissue specimens of the tumors of 90 NMIBC patients. Median follow-up was 77 months (range 2-158). Patients with Chr17 polysomy or HER2 gene amplification had a higher rate of disease progression (hazard ratio: 7.44; p < 0.001 and 4.04; p = 0.033, respectively; univariate Cox regression). Multivariable Cox regression models demonstrated that the addition of either Chr17 polysomy or HER2 gene amplification status to the European Association of Urology (EAU) progression risk score increases the c-index (from 0.741/EAU/ to 0.793 and 0.755, respectively), indicating that Chr17 polysomy/HER2 amplification status information improves the accuracy of the EAU risk table in predicting disease progression. HER2/Chr17 in situ hybridization can be used to select non-progressive cases not requiring strict follow-up, by reclassifying non-HER2-amplified, non-polysomic NMIBCs from the high- and very high-risk groups of EAU to the intermediate-risk group. Funding 2019494 /api/funding/2019494 false true Funding 2019495 /api/funding/2019495 false true Funding 2019496 /api/funding/2019496 false true Funding 2019497 /api/funding/2019497 false true Funding 2019498 /api/funding/2019498 false true Funding 2019499 /api/funding/2019499 false true true 2022 true true true false true false GOLD 2026-07-03 true https://doi.org/10.3390/cancers14194570 3 0 3 3 0 3 2 1 2 2 2 2 2 3 0 0 3 3 3 3 0 1 1 Folyóiratcikk Journal Article 24 3 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 1 1 1 2024 0 0 0 0 0 2025 0 1 1 1 1 2026 0 1 1 1 1 Q1 false 10024665,10016981,10061496 false false false 2022-10-18T10:58:51.911+0000 Akadémikus bibliográfia; Pathologiai Intézet (PTE / ÁOK); Patológiai, Igazságügyi és Biztosítási Orvostan... (SE / AOK / I); Urológiai Klinika (SE / AOK / K) 10 23 4 12 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 103864130 /api/authorship/103864130 1 0.083 true false true Author 10061659 /api/author/10061659 Kocsmár Ildikó true 10061659 true Kocsmár Ildikó true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103864131 /api/authorship/103864131 2 0.083 false false false Author 10061496 /api/author/10061496 Kocsmár Éva true 10061496 true Kocsmár Éva true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103864132 /api/authorship/103864132 3 0.083333336 false false false Author 10025578 /api/author/10025578 Pajor Gábor true 10025578 true Pajor Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103864133 /api/authorship/103864133 4 0.083 false false false Author 10017900 /api/author/10017900 Kulka Janina true 10017900 true Kulka Janina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103864134 /api/authorship/103864134 5 0.083 false false false Author 10023805 /api/author/10023805 Székely Eszter DUPLUM true 10023805 true Székely Eszter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103864135 /api/authorship/103864135 6 0.083333336 false false false Kristiansen Glen true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103864136 /api/authorship/103864136 7 0.083333336 false false false Schilling Oliver true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103864137 /api/authorship/103864137 8 0.083 false false false Author 10013343 /api/author/10013343 Nyirády Péter true 10013343 true Nyirády Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103864138 /api/authorship/103864138 9 0.083 false false false Author 10000554 /api/author/10000554 Kiss András true 10000554 true Kiss András true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103864139 /api/authorship/103864139 10 0.083 false false false Author 1323309 /api/author/1323309 Schaff Zsuzsa true 1323309 true Schaff Zsuzsa true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103864140 /api/authorship/103864140 11 0.083 false true false Author 10024665 /api/author/10024665 Riesz Péter true 10024665 true Riesz Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103864141 /api/authorship/103864141 12 0.083 false true true Author 10016981 /api/author/10016981 Lotz Gábor true 10016981 true Lotz Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true Institute 19040 /api/institute/19040 0 false false true Akadémikus bibliográfia Bibliografy of Hungarian of Academy of Sciences' academicians true 19040 true PublicationIdentifier 21872861 /api/publicationidentifier/21872861 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/cancers14194570 https://doi.org/10.3390/cancers14194570 false true PublicationIdentifier 21935089 /api/publicationidentifier/21935089 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000866672400001 https://www.webofscience.com/wos/woscc/full-record/000866672400001 false true PublicationIdentifier 21935088 /api/publicationidentifier/21935088 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus 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true true Keyword 2755218 /api/keyword/2755218 true true SjrRating 11315334 /api/sjrrating/11315334 81 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2730 /api/classificationexternal/2730 true 2730 true Q1 DIRECT true true /api/publication/33163272 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10061659"><a href="/gui2/?type=authors&mode=browse&sel=10061659" target="_blank">Kocsmár Ildikó ✉ (<span class="authorship-author-name">Kocsmár Ildikó</span> <span class="authorAux-mtmt"> patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061496"><a href="/gui2/?type=authors&mode=browse&sel=10061496" target="_blank">Kocsmár Éva (<span class="authorship-author-name">Kocsmár Éva</span> <span class="authorAux-mtmt"> patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025578"><a href="/gui2/?type=authors&mode=browse&sel=10025578" target="_blank">Pajor Gábor (<span class="authorship-author-name">Pajor Gábor</span> <span class="authorAux-mtmt"> Pathológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Pathologiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017900"><a href="/gui2/?type=authors&mode=browse&sel=10017900" target="_blank">Kulka Janina (<span class="authorship-author-name">Kulka Janina</span> <span class="authorAux-mtmt"> Emlőpathológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023805"><a href="/gui2/?type=authors&mode=browse&sel=10023805" target="_blank">Székely Eszter (<span class="authorship-author-name">Székely Eszter</span> <span class="authorAux-mtmt"> patologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kristiansen Glen </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schilling Oliver </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013343"><a href="/gui2/?type=authors&mode=browse&sel=10013343" target="_blank">Nyirády Péter (<span class="authorship-author-name">Nyirády Péter</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000554"><a href="/gui2/?type=authors&mode=browse&sel=10000554" target="_blank">Kiss András (<span class="authorship-author-name">Kiss András</span> <span class="authorAux-mtmt"> Pathológia, hepatocarcinogenesis</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1323309"><a href="/gui2/?type=authors&mode=browse&sel=1323309" target="_blank">Schaff Zsuzsa (<span class="authorship-author-name">Schaff Zsuzsa</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024665"><a href="/gui2/?type=authors&mode=browse&sel=10024665" target="_blank">Riesz Péter<sup>**</sup> (<span class="authorship-author-name">Riesz Péter</span> <span class="authorAux-mtmt"> urológia, andrológia, klinikai onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10016981"><a href="/gui2/?type=authors&mode=browse&sel=10016981" target="_blank">Lotz Gábor ✉ (<span class="authorship-author-name">Lotz Gábor</span> <span class="authorAux-mtmt"> Hepatológia, pathológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33163272" target="_blank">Addition of Chromosome 17 Polysomy and HER2 Amplification Status Improves the Accuracy of Clinicopathological Factor-Based Progression Risk Stratification and Tumor Grading of Non-Muscle-Invasive Bladder Cancer.</a></div> <div> <span class="journal-title">CANCERS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2072-6694">2072-6694</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">19</span> <span class="page"> Paper 4570. 19 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/cancers14194570" target="_blank" href="https://doi.org/10.3390/cancers14194570"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000866672400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000866672400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85139921971" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85139921971"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36230493" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36230493&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 3</span> | Független: 3 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;2 | WoS/Scopus jelölt:&nbsp;2 | DOI jelölt:&nbsp;2 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33163272&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33163272</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="special-affiliations"> Speciális affiliáció: Akadémikus bibliográfia </div> <div class="funder"> Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Támogató: EFOP-VEKOP, (K128881) Támogató: OTKA, (K_22 142604) Támogató: OTKA, (UNKP-20-3-II-SE-36) Támogató: Innovációs és Technológiai Minisztérium, (ÚNKP-21-4-I-SE-32), Tématerületi Kiválósági Program(2020-4.1.1.-TKP2020) </div> <div class="lastModified">Utolsó módosítás: 2025.07.01. 21:17 Ladányi Gusztáv (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: * Megosztott szerzőség</pre> </div></div>