(Open access funding provided by Semmelweis University)
Szakterületek:
Klinikai orvostan
The concept of precision medicine is based on the identification of hallmarks of cancer
to exploit them as drug targets. The basic idea was that in this way the therapeutic
modalities will be more effective and the side effects will be less. Since the majority
of these novel modalities are not specific for a cancer-related biological process
or a cancer-specific (mutant) target protein, it is not a surprise that we had to
learn new type of side effects, because these therapeutics also affect physiological
or pathological processes. Even more, in cases of some of these novel therapies we
were able to discover new molecular mechanisms of physiological and pathological processes.
Identification of the on-target side effects of targeted drugs can help to prevent
the development of them or better manage the patients when emerge during cancer therapy.
