https://m2.mtmt.hu/ hun 2026-10-23 02:52 JournalArticle 33153589 VALIDATED true Department of Internal Medicine and Oncology, European Reference Network on Rare Endocrine Conditions (ENDO-ERN), Health Care Provider (HCP), Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Internal Medicine and Haematology, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Surgery, Transplantation and Gastroenterology, Faculty of Medicine, Semmelweis University, Budapest, Hungary First Department of Pathology and Experimental Cancer Research, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Pathology, Forensic and Insurance Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Endocrinology, European Network for the Study of Adrenal Tumours (ENS@T) Research Center of Excellence, Faculty of Medicine, Semmelweis University, Budapest, Hungary Magyar Tudományos Akadémia-Semmelweis Egyetem (MTA-SE) Molecular Medicine Research Group, Eötvös Loránd Research Network, Budapest, Hungary Cited By :1 Export Date: 3 April 2023 Correspondence Address: Tóth, M.; Department of Internal Medicine and Oncology, Hungary; email: toth.miklos@med.semmelweis-univ.hu 0 false 2026-10-22T19:59:42.308+0000 2022-10-28T08:29:21.535+0000 2022-10-15T12:05:27.955+0000 true 10071338 Molnár-Taga Márta /api/admin/10071338 Admin true 2025-06-16T07:37:55.751+0000 2025-06-16T07:37:55.751+0000 2022-10-28T08:29:21.542+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Tőke, Judit Prognostic factors and mitotane treatment of adrenocortical cancer. Two decades of experience from an institutional case series true true /api/journal/10017752 REVIEWED true false 10017752 false 10017752 true 1664-2392 1664-2392 Journal FOREIGN 13 952418 952418 11 2022 <sec>ObjectivesThis study aimed to characterise the clinicopathological features and prognostic factors of a large cohort of Hungarian patients with adrenocortical cancer diagnosed between 2000-2021.</sec><sec>Patients and methodsThis retrospective study included seventy-four patients (27 men and 47 women) with histologically confirmed adrenocortical cancer in a single tertiary referral endocrine centre. Descriptive statistics were performed, providing summaries of selected clinical and pathological parameters. Clinicopathological factors contributing to overall survival were analysed.</sec><sec>ResultsThe median age of patients was 48,5 years (17-84 years) at diagnosis. The majority of cases were diagnosed at ENSAT stage II (39,2%) and stage IV (33,8%). At diagnosis, the median tumour size was 9,0 cm (4,5-20 cm). In 47 patients (71,6%), the tumour was hormonally active. The median overall survival and the 5-year survival rate were 23,5 months (95% CI, 17-30,5 months) and 18,3%, respectively. Primary tumour resection was performed in 68 patients (91,8%); R0 surgical resection was achieved in 30 patients. In univariate Cox regression model, tumours with stages III and IV, high proliferative activity (Ki67-index > 10%), R1-R2 surgical resection state and hormonal activity were associated with poorer survival. Cortisol excess, both isolated and combined with androgen production, was associated with poorer survival. Fifty-five patients were treated with mitotane. The overall survival of patients achieving therapeutic mitotane plasma concentration was significantly better compared to those who never reached it [27.0 (2-175) months vs 18.0 (2-83) months; p<0.05)]. The median age, the distribution of gender, ENSAT stage, resection state and Ki67-index did not differ between these two groups. The time needed to reach the therapeutic range of serum mitotane was 96.5 days (95% CI, 75-133 days).</sec><sec>ConclusionOur results confirm previous data that disease stage, mitotic activity, the resection state and the mitotane treatment achieving therapeutic concentration are the most critical parameters influencing the prognosis of adrenocortical cancer. Our data suggest that hormonal activity may be more frequent than described previously, and it is a strong and independent prognostic factor of overall survival. To our knowledge, this is the first single-centre study confirming the prognostic importance of achieving therapeutic mitotane concentration.</sec> true true 2022 true true true false true false GOLD 2026-10-22 true https://doi.org/10.3389/fendo.2022.952418 13 0 13 11 3 12 13 12 12 13 13 11 11 11 2 0 13 11 13 11 0 3 3 Folyóiratcikk Journal Article 24 13 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 1 1 1 2024 0 4 3 4 3 2025 0 5 5 5 5 2026 0 3 2 3 2 Q1 false 10014760,10023807,10043702,10013690 false false false 2022-10-17T15:59:26.269+0000 Belgyógyászati és Hematológiai Klinika (SE / AOK / K); Belgyógyászati és Onkológiai Klinika (SE / AOK / K); Endokrinológiai Tanszék (SE / AOK / K / BOK); MTA-SE Molekuláris Medicina Kutatócsoport (SE / AOK / K / BOK); Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I); Patológiai, Igazságügyi és Biztosítási Orvostan... (SE / AOK / I); Sebészeti, Transzplantációs és Gasztroenterológ... (SE / AOK / K) 11 32 7 11 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 103813275 /api/authorship/103813275 1 0.091 true false false Author 10043702 /api/author/10043702 Tőke Judit true 10043702 true Tőke Judit true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103813276 /api/authorship/103813276 2 0.091 false false false Author 10049763 /api/author/10049763 Uhlyarik Andrea true 10049763 true Uhlyarik Andrea true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103813277 /api/authorship/103813277 3 0.091 false false false Author 10085765 /api/author/10085765 Lohinszky Júlia true true Lohinszky Júlia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103813278 /api/authorship/103813278 4 0.091 false false false Author 10026210 /api/author/10026210 Stark Júlia true 10026210 true Stark Júlia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103813279 /api/authorship/103813279 5 0.091 false false false Author 10026081 /api/author/10026081 Huszty Gergely true 10026081 true Huszty Gergely true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103813280 /api/authorship/103813280 6 0.091 false false false Author 10025105 /api/author/10025105 Micsik Tamás true 10025105 true Micsik Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103813281 /api/authorship/103813281 7 0.091 false false false Author 10023807 /api/author/10023807 Borka Katalin true 10023807 true Borka Katalin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103813282 /api/authorship/103813282 8 0.091 false false false Author 10013690 /api/author/10013690 Reismann Péter true 10013690 true Reismann Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103813283 /api/authorship/103813283 9 0.091 false false false Author 10005620 /api/author/10005620 Horányi János true 10005620 true Horányi János true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103813284 /api/authorship/103813284 10 0.091 false false false Author 10000070 /api/author/10000070 Igaz Péter true 10000070 true Igaz Peter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103813285 /api/authorship/103813285 11 0.091 false true true Author 10014760 /api/author/10014760 Tóth Miklós true 10014760 true Tóth Miklós true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 21845493 /api/publicationidentifier/21845493 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD 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/api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36246926 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36246926&dopt=Abstract true true Classification 12284 /api/classification/12284 true true Classification 12215 /api/classification/12215 true true SjrRating 11312540 /api/sjrrating/11312540 36 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2712 /api/classificationexternal/2712 true 2712 true Q1 DIRECT true true /api/publication/33153589 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10043702"><a href="/gui2/?type=authors&mode=browse&sel=10043702" target="_blank">Tőke Judit (<span class="authorship-author-name">Tőke Judit</span> <span class="authorAux-mtmt"> Belgyógyászat, Endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10049763"><a href="/gui2/?type=authors&mode=browse&sel=10049763" target="_blank">Uhlyarik Andrea (<span class="authorship-author-name">Uhlyarik Andrea</span> <span class="authorAux-mtmt"> onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10085765"><a href="/gui2/?type=authors&mode=browse&sel=10085765" target="_blank">Lohinszky Júlia (<span class="authorship-author-name">Lohinszky Júlia</span> <span class="authorAux-mtmt"> belgyógyászat, klinikai onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026210"><a href="/gui2/?type=authors&mode=browse&sel=10026210" target="_blank">Stark Júlia (<span class="authorship-author-name">Stark Júlia</span> <span class="authorAux-mtmt"> általános orvos</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026081"><a href="/gui2/?type=authors&mode=browse&sel=10026081" target="_blank">Huszty Gergely (<span class="authorship-author-name">Huszty Gergely</span> <span class="authorAux-mtmt"> Sebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Sebészeti, Transzplantációs és Gasztroenterológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025105"><a href="/gui2/?type=authors&mode=browse&sel=10025105" target="_blank">Micsik Tamás (<span class="authorship-author-name">Micsik Tamás</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023807"><a href="/gui2/?type=authors&mode=browse&sel=10023807" target="_blank">Borka Katalin (<span class="authorship-author-name">Borka Katalin</span> <span class="authorAux-mtmt"> patologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013690"><a href="/gui2/?type=authors&mode=browse&sel=10013690" target="_blank">Reismann Péter (<span class="authorship-author-name">Reismann Péter</span> <span class="authorAux-mtmt"> belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10005620"><a href="/gui2/?type=authors&mode=browse&sel=10005620" target="_blank">Horányi János (<span class="authorship-author-name">Horányi János</span> <span class="authorAux-mtmt"> Endokrin sebészet, sebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Sebészeti, Transzplantációs és Gasztroenterológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000070"><a href="/gui2/?type=authors&mode=browse&sel=10000070" target="_blank">Igaz Peter (<span class="authorship-author-name">Igaz Péter</span> <span class="authorAux-mtmt"> belgyógyászat, endokrinológia, klinikai molekul...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Belgyógyászati és Onkológiai Klinika">BOK</span>/MTA-SE Molekuláris Medicina Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Belgyógyászati és Onkológiai Klinika">BOK</span>/Endokrinológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014760"><a href="/gui2/?type=authors&mode=browse&sel=10014760" target="_blank">Tóth Miklós ✉ (<span class="authorship-author-name">Tóth Miklós</span> <span class="authorAux-mtmt"> Belgyógyászat, Endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33153589" target="_blank">Prognostic factors and mitotane treatment of adrenocortical cancer. Two decades of experience from an institutional case series</a></div> <div> <span class="journal-title">FRONTIERS IN ENDOCRINOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-2392">1664-2392</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-2392">1664-2392</a>)</span>: <span class="journal-volume">13</span> <span class="page"> Paper 952418. 11 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fendo.2022.952418" target="_blank" href="https://doi.org/10.3389/fendo.2022.952418"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000868434300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000868434300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85139963487" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85139963487"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36246926" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36246926&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 13</span> | Független: 11 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 12 | Scopus jelölt:&nbsp;12 | WoS/Scopus jelölt:&nbsp;13 | DOI jelölt:&nbsp;13 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33153589&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33153589</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="lastModified">Utolsó módosítás: 2022.10.28. 10:29 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Internal Medicine and Oncology, European Reference Network on Rare Endocrine Conditions (ENDO-ERN), Health Care Provider (HCP), Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Internal Medicine and Haematology, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Surgery, Transplanta...</pre> </div></div>