https://m2.mtmt.hu/ eng 2026-06-24 14:30 JournalArticle 33133181 APPROVED true Department of Urology, University of Duisburg-Essen, Essen, Germany Dr. Senckenberg Institute of Pathology, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main, Germany Department of Urology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany Institute of Pathology, University Medicine Essen, University of Duisburg-Essen, Essen, Germany Department of Medical Oncology, University of Duisburg-Essen, Essen, Germany Department of Urology, Semmelweis University, Budapest, Hungary Research Centre for Natural Sciences, Cancer Biomarker Research Group, Institute of Enzymology, Budapest, Hungary 2nd Department of Pediatrics and Department of Bioinformatics, Semmelweis University, Budapest, Hungary 2nd Department of Pathology, Semmelweis University, Budapest, Hungary Department of Translational Medicine, Lund University, Lund, Sweden Cited By :4 Export Date: 30 January 2024 Correspondence Address: Szarvas, T.; Department of Urology, Germany; email: tibor.szarvas@uk-essen.de Chemicals/CAS: baculoviral IAP repeat containing protein 5, 195263-98-0; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; matrilysin, 141256-52-2; platinum, 7440-06-4; protein serine threonine kinase Manufacturers: Qiagen, Germany; Thermo Scientific, United States 0 false 2026-05-22T05:09:34.954+0000 2025-02-26T14:13:35.437+0000 2022-10-10T08:47:23.880+0000 true 10035718 Sonnevend Kinga /api/admin/10035718 Admin true 10035718 2025-08-25T10:02:21.024+0000 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2024-04-04T10:40:39.722+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Oláh, Csilla Predictive value of molecular subtypes and APOBEC3G for adjuvant chemotherapy in urothelial bladder cancer true true /api/journal/10037907 REVIEWED true false 10037907 false 10037907 true 2045-7634 2045-7634 Journal FOREIGN 12 5 5222 5232 5222 11 2023 Although targeted approaches have become available in second‐ and third‐line settings, platinum‐based chemotherapy remains the standard first‐line treatment for advanced muscle‐invasive bladder cancer (MIBC). Therefore, the prediction of platinum resistance is of utmost clinical importance.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>In this study, we established a routine compatible method for the molecular classification of MIBC samples according to various classification systems and applied this method to evaluate the impact of subtypes on survival after adjuvant chemotherapy. This retrospective study included 191 patients with advanced MIBC (pT≥3 or pN+) who underwent radical cystectomy, with or without adjuvant chemotherapy. A 48‐gene panel and classifier rule set were established to determine molecular subtypes according to TCGA, MDA, LundTax, and Consensus classifications. Additionally, 12 single platinum‐predictive candidate genes were assessed. The results were correlated with patients' clinicopathological and follow‐up data and were validated using independent data sets.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Our final evaluation of 159 patients demonstrated better survival in the luminal groups for those who received chemotherapy compared with those who did not. In contrast, no such differences were observed in basal subtypes. The use of chemotherapy was associated with better survival in patients with high <jats:italic>APOBEC3G</jats:italic> expression (<jats:italic>p</jats:italic> < 0.002). This association was confirmed using an independent data set of patients who received neoadjuvant platinum therapy.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The proposed method robustly replicates the most commonly used transcriptome‐based subtype classifications from paraffin‐embedded tissue samples. The luminal, but not basal, molecular subtypes had the greatest benefit from adjuvant platinum therapy. We identified and validated <jats:italic>APOBEC3G</jats:italic> as a novel predictive marker for platinum‐treated patients. Funding 2019381 /api/funding/2019381 false true Funding 2019382 /api/funding/2019382 false true Funding 2019383 /api/funding/2019383 false true Funding 2019384 /api/funding/2019384 false true true 2022 true true true false true false NONE 2026-05-22 false 14 0 14 5 6 13 14 13 12 14 14 5 5 5 9 0 14 5 14 5 0 3 3 Folyóiratcikk Journal Article 24 14 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 4 1 4 1 2024 0 1 0 1 0 2025 0 7 3 7 3 2026 0 2 1 2 1 Q1 false 10052466 false false false 2023-01-08T09:48:14.811+0000 Bioinformatika Tanszék (SE / AOK / I); Enzimológiai Intézet (TTK); II. Sz. Gyermekgyógyászati Klinika (SE / AOK / K); II. Sz. 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10.1016/j.cell.2017.09.007 false true Reference 34190769 /api/reference/34190769 12 10.1016/j.eururo.2019.09.006 false true Reference 34190770 /api/reference/34190770 13 10.1016/j.eururo.2017.11.023 false true Reference 34190771 /api/reference/34190771 14 10.1097/JU.0000000000002261 false true Reference 34190772 /api/reference/34190772 15 10.1038/s41467-020-18640-0 false true Reference 34190773 /api/reference/34190773 16 false true Reference 34190774 /api/reference/34190774 17 10.1002/ijc.33809 false true Reference 34190775 /api/reference/34190775 18 10.1016/j.urolonc.2019.04.010 false true Reference 34190776 /api/reference/34190776 19 10.1158/1078-0432.CCR-18-3558 false true Reference 34190777 /api/reference/34190777 20 10.1016/j.urolonc.2019.11.004 false true Reference 34190778 /api/reference/34190778 21 10.1158/1078-0432.CCR-07-0109 false true Reference 34190779 /api/reference/34190779 22 10.1186/1471-2407-12-526 false true Reference 34190780 /api/reference/34190780 23 false true Reference 34190781 /api/reference/34190781 24 10.1016/j.urolonc.2019.04.015 false true Reference 34190782 /api/reference/34190782 25 10.1038/cdd.2013.67 false true Reference 34190783 /api/reference/34190783 26 10.1136/jitc-2019-000162 false true Reference 34190784 /api/reference/34190784 27 10.1002/JLB.2MR0717-310R false true Reference 34190785 /api/reference/34190785 28 false true Reference 34190786 /api/reference/34190786 29 false true Reference 34190787 /api/reference/34190787 30 10.1172/JCI45008 false true Reference 34190788 /api/reference/34190788 31 10.1097/CAD.0000000000000082 false true Reference 34190789 /api/reference/34190789 32 10.7150/jca.46383 false true Reference 34190790 /api/reference/34190790 33 10.1007/978-1-4939-7234-0_8 false true /api/publication/33133181 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10051826"><a href="/gui2/?type=authors&mode=browse&sel=10051826" target="_blank">Oláh Csilla (<span class="authorship-author-name">Oláh Csilla</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Reis Henning </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hoffmann Michèle J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mairinger Fabian </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ting Saskia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hadaschik Boris </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Krafft Ulrich </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Grünwald Viktor </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013343"><a href="/gui2/?type=authors&mode=browse&sel=10013343" target="_blank">Nyirady Peter (<span class="authorship-author-name">Nyirády Péter</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Urology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074880"><a href="/gui2/?type=authors&mode=browse&sel=10074880" target="_blank">Varadi Melinda (<span class="authorship-author-name">Váradi Melinda</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Urology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000109"><a href="/gui2/?type=authors&mode=browse&sel=10000109" target="_blank">Győrffy Balázs (<span class="authorship-author-name">Győrffy Balázs</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/II. Department of Pediatrics; <span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_417; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Bioinformatika Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000554"><a href="/gui2/?type=authors&mode=browse&sel=10000554" target="_blank">Kiss Andras (<span class="authorship-author-name">Kiss András</span> <span class="authorAux-mtmt"> Pathológia, hepatocarcinogenesis</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/II. Department of Pathology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023805"><a href="/gui2/?type=authors&mode=browse&sel=10023805" target="_blank">Szekely Eszter (<span class="authorship-author-name">Székely Eszter</span> <span class="authorAux-mtmt"> patologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/II. Department of Pathology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sjödahl Gottfrid </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052466"><a href="/gui2/?type=authors&mode=browse&sel=10052466" target="_blank">Szarvas Tibor ✉ (<span class="authorship-author-name">Szarvas Tibor</span> <span class="authorAux-mtmt"> urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Urology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33133181" target="_blank">Predictive value of molecular subtypes and APOBEC3G for adjuvant chemotherapy in urothelial bladder cancer</a></div> <div> <span class="journal-title">CANCER MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-7634">2045-7634</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-7634">2045-7634</a>)</span>: <span class="journal-volume">12</span> <span class="journal-issue">5</span> <span class="page"> pp 5222-5232 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1002/cam4.5324" target="_blank" href="https://doi.org/10.1002/cam4.5324"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000864574700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000864574700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85139405337" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85139405337"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36204983" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36204983&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Oncology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Radiology, Nuclear Medicine and Imaging&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 14</span> | Independent citation: 5 | Self citation: 9 | Unknown citation: 0 | Number of citations in WoS: 13 | Number of citations in Scopus:&nbsp;12 | WoS/Scopus assigned:&nbsp;14 | Number of citations with DOI:&nbsp;14 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33133181&sort=publishedYear,desc&sort=title"> Number of cited publications: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33133181</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (BO/00451/20/5), (K139059), Tématerületi Kiválósági Program(2020-4.1.1.-TKP2020), (ÚNKP-21-5-SE-3) </div> <div class="lastModified">Last Modified: 2025.02.26. 15:13 Gusztáv Ladányi (MTMT API user, admin) </div> <div class="lockedBy">Centrally managed 2024.04.04. 12:40 Andrea Vándor (VA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Urology, University of Duisburg-Essen, Essen, Germany Dr. Senckenberg Institute of Pathology, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main, Germany Department of Urology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany ...</pre> </div></div>