https://m2.mtmt.hu/ hun 2026-05-26 13:03 JournalArticle 33133181 APPROVED true Department of Urology, University of Duisburg-Essen, Essen, Germany Dr. Senckenberg Institute of Pathology, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main, Germany Department of Urology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany Institute of Pathology, University Medicine Essen, University of Duisburg-Essen, Essen, Germany Department of Medical Oncology, University of Duisburg-Essen, Essen, Germany Department of Urology, Semmelweis University, Budapest, Hungary Research Centre for Natural Sciences, Cancer Biomarker Research Group, Institute of Enzymology, Budapest, Hungary 2nd Department of Pediatrics and Department of Bioinformatics, Semmelweis University, Budapest, Hungary 2nd Department of Pathology, Semmelweis University, Budapest, Hungary Department of Translational Medicine, Lund University, Lund, Sweden Cited By :4 Export Date: 30 January 2024 Correspondence Address: Szarvas, T.; Department of Urology, Germany; email: tibor.szarvas@uk-essen.de Chemicals/CAS: baculoviral IAP repeat containing protein 5, 195263-98-0; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; matrilysin, 141256-52-2; platinum, 7440-06-4; protein serine threonine kinase Manufacturers: Qiagen, Germany; Thermo Scientific, United States 0 false 2026-05-22T05:09:34.954+0000 2025-02-26T14:13:35.437+0000 2022-10-10T08:47:23.880+0000 true 10035718 Sonnevend Kinga /api/admin/10035718 Admin true 10035718 2025-08-25T10:02:21.024+0000 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2024-04-04T10:40:39.722+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Oláh, Csilla Predictive value of molecular subtypes and APOBEC3G for adjuvant chemotherapy in urothelial bladder cancer true true /api/journal/10037907 REVIEWED true false 10037907 false 10037907 true 2045-7634 2045-7634 Journal FOREIGN 12 5 5222 5232 5222 11 2023 Although targeted approaches have become available in second‐ and third‐line settings, platinum‐based chemotherapy remains the standard first‐line treatment for advanced muscle‐invasive bladder cancer (MIBC). Therefore, the prediction of platinum resistance is of utmost clinical importance.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>In this study, we established a routine compatible method for the molecular classification of MIBC samples according to various classification systems and applied this method to evaluate the impact of subtypes on survival after adjuvant chemotherapy. This retrospective study included 191 patients with advanced MIBC (pT≥3 or pN+) who underwent radical cystectomy, with or without adjuvant chemotherapy. A 48‐gene panel and classifier rule set were established to determine molecular subtypes according to TCGA, MDA, LundTax, and Consensus classifications. Additionally, 12 single platinum‐predictive candidate genes were assessed. The results were correlated with patients' clinicopathological and follow‐up data and were validated using independent data sets.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Our final evaluation of 159 patients demonstrated better survival in the luminal groups for those who received chemotherapy compared with those who did not. In contrast, no such differences were observed in basal subtypes. The use of chemotherapy was associated with better survival in patients with high <jats:italic>APOBEC3G</jats:italic> expression (<jats:italic>p</jats:italic> < 0.002). This association was confirmed using an independent data set of patients who received neoadjuvant platinum therapy.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The proposed method robustly replicates the most commonly used transcriptome‐based subtype classifications from paraffin‐embedded tissue samples. The luminal, but not basal, molecular subtypes had the greatest benefit from adjuvant platinum therapy. We identified and validated <jats:italic>APOBEC3G</jats:italic> as a novel predictive marker for platinum‐treated patients. 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Sz. Gyermekgyógyászati Klinika (SE / AOK / K); II. Sz. 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Reference 34190781 /api/reference/34190781 24 10.1016/j.urolonc.2019.04.015 false true Reference 34190782 /api/reference/34190782 25 10.1038/cdd.2013.67 false true Reference 34190783 /api/reference/34190783 26 10.1136/jitc-2019-000162 false true Reference 34190784 /api/reference/34190784 27 10.1002/JLB.2MR0717-310R false true Reference 34190785 /api/reference/34190785 28 false true Reference 34190786 /api/reference/34190786 29 false true Reference 34190787 /api/reference/34190787 30 10.1172/JCI45008 false true Reference 34190788 /api/reference/34190788 31 10.1097/CAD.0000000000000082 false true Reference 34190789 /api/reference/34190789 32 10.7150/jca.46383 false true Reference 34190790 /api/reference/34190790 33 10.1007/978-1-4939-7234-0_8 false true /api/publication/33133181 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10051826"><a href="/gui2/?type=authors&mode=browse&sel=10051826" target="_blank">Oláh Csilla (<span class="authorship-author-name">Oláh Csilla</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Reis Henning </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hoffmann Michèle J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mairinger Fabian </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ting Saskia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hadaschik Boris </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Krafft Ulrich </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Grünwald Viktor </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013343"><a href="/gui2/?type=authors&mode=browse&sel=10013343" target="_blank">Nyirady Peter (<span class="authorship-author-name">Nyirády Péter</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074880"><a href="/gui2/?type=authors&mode=browse&sel=10074880" target="_blank">Varadi Melinda (<span class="authorship-author-name">Váradi Melinda</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000109"><a href="/gui2/?type=authors&mode=browse&sel=10000109" target="_blank">Győrffy Balázs (<span class="authorship-author-name">Győrffy Balázs</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/II. Sz. Gyermekgyógyászati Klinika; <span title="Természettudományi Kutatóközpont">TTK</span>/<span title="Molekuláris Élettudományi Intézet">MÉI</span>/Onkológiai Biomarker Kutatócsoport (Lendület); <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Bioinformatika Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000554"><a href="/gui2/?type=authors&mode=browse&sel=10000554" target="_blank">Kiss Andras (<span class="authorship-author-name">Kiss András</span> <span class="authorAux-mtmt"> Pathológia, hepatocarcinogenesis</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/II. Sz. Patológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023805"><a href="/gui2/?type=authors&mode=browse&sel=10023805" target="_blank">Szekely Eszter (<span class="authorship-author-name">Székely Eszter</span> <span class="authorAux-mtmt"> patologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/II. Sz. Patológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sjödahl Gottfrid </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052466"><a href="/gui2/?type=authors&mode=browse&sel=10052466" target="_blank">Szarvas Tibor ✉ (<span class="authorship-author-name">Szarvas Tibor</span> <span class="authorAux-mtmt"> urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33133181" target="_blank">Predictive value of molecular subtypes and APOBEC3G for adjuvant chemotherapy in urothelial bladder cancer</a></div> <div> <span class="journal-title">CANCER MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-7634">2045-7634</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-7634">2045-7634</a>)</span>: <span class="journal-volume">12</span> <span class="journal-issue">5</span> <span class="page"> pp 5222-5232 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1002/cam4.5324" target="_blank" href="https://doi.org/10.1002/cam4.5324"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000864574700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000864574700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85139405337" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85139405337"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36204983" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36204983&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Radiology, Nuclear Medicine and Imaging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 14</span> | Független: 5 | Függő: 9 | Nem jelölt: 0 | WoS jelölt: 13 | Scopus jelölt:&nbsp;12 | WoS/Scopus jelölt:&nbsp;14 | DOI jelölt:&nbsp;14 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33133181&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33133181</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (BO/00451/20/5), (K139059), Tématerületi Kiválósági Program(2020-4.1.1.-TKP2020), (ÚNKP-21-5-SE-3) </div> <div class="lastModified">Utolsó módosítás: 2025.02.26. 15:13 Ladányi Gusztáv (MTMT API user, admin) </div> <div class="lockedBy">Központi kezelésű 2024.04.04. 12:40 Vándor Andrea (VA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Urology, University of Duisburg-Essen, Essen, Germany Dr. Senckenberg Institute of Pathology, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main, Germany Department of Urology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany ...</pre> </div></div>