https://m2.mtmt.hu/ eng 2026-08-24 06:18 JournalArticle 33132334 APPROVED true Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom Department of Rheumatology, Queen Elizabeth Hospital, London, United Kingdom Department of Genetics Cell-and Immunobiology, Semmelweis University, Budapest, Hungary Department of Rheumatology and Clinical Immunology, Department of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary Heart and Vascular Center, Semmelweis University, Budapest, Hungary Centre for Rheumatic Diseases, King's College London, London, United Kingdom Cited By :2 Export Date: 20 September 2023 CODEN: RUMAF Correspondence Address: Dey, M.; Institute of Life Course and Medical Sciences, Brownlow Hill, United Kingdom; email: Mrinalini.dey@nhs.net 0 false 2026-07-31T15:16:22.422+0000 2026-07-02T10:21:30.812+0000 2022-10-09T18:47:43.319+0000 true 10071338 Molnár-Taga Márta /api/admin/10071338 Admin true 2026-07-17T06:07:45.169+0000 2026-07-17T06:07:45.169+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Dey, Mrinalini Comorbidities and extra-articular manifestations in difficult-to-treat rheumatoid arthritis: different sides of the same coin? true true /api/journal/25853 REVIEWED true false 25853 false 25853 true 1462-0324 1462-0332 Journal FOREIGN 62 5 1773 1779 1773 7 2023 Despite the improvement in treatment for people with rheumatoid arthritis (RA), approximately 30% of patients remain symptomatic in the presence of optimised medical therapy, described as having “difficult-to-treat” (D2T) RA. The average patient with RA has 1.6 other clinical conditions, which accumulate over time. Comorbidities are increasingly recognised as key contributors to D2T disease, and are themselves perpetuated by the D2T state. In this review, we discuss the commonest comorbidities in the context of D2T RA. We propose the need for a paradigm shift in the clinical and research agenda for comorbidities- including a need to consider and manage these prior to the development of D2T disease and not as an afterthought. true true 2022 true true true false true false NONE 2026-07-31 false 58 0 58 46 9 57 58 49 54 56 56 44 44 46 12 0 58 46 58 46 0 8 8 Folyóiratcikk Journal Article 24 56 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 9 8 9 8 2024 0 15 15 15 15 2025 0 15 11 15 11 2026 0 19 12 19 12 D1 false false false false 2023-01-07T19:49:51.932+0000 Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I); Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K); Reumatológiai és Klinikai Immunológiai Tanszék (SE / AOK / K / BOK) 1 16 3 3 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 103704377 /api/authorship/103704377 1 0.333 true false true Dey Mrinalini true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103704378 /api/authorship/103704378 2 0.333 false false false Author 10025749 /api/author/10025749 Nagy György true 10025749 true Nagy Gyorgy true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103704379 /api/authorship/103704379 3 0.33333334 false true false Nikiphorou Elena true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 21774865 /api/publicationidentifier/21774865 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true NONE IDENTICAL 10.1093/rheumatology/keac584 https://doi.org/10.1093/rheumatology/keac584 false true PublicationIdentifier 21967084 /api/publicationidentifier/21967084 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000871668600001 https://www.webofscience.com/wos/woscc/full-record/000871668600001 false true PublicationIdentifier 23697591 /api/publicationidentifier/23697591 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85149894565 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85149894565 false true PublicationIdentifier 21774866 /api/publicationidentifier/21774866 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36205537 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36205537&dopt=Abstract true true Classification 12215 /api/classification/12215 true true Classification 12282 /api/classification/12282 true true SjrRating 11406434 /api/sjrrating/11406434 13 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2736 /api/classificationexternal/2736 true 2736 true D1 DIRECT true true /api/publication/33132334 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Dey Mrinalini ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025749"><a href="/gui2/?type=authors&mode=browse&sel=10025749" target="_blank">Nagy Gyorgy (<span class="authorship-author-name">Nagy György</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Genetics, Cell- and Immunology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Internal Medicine and Oncology">DIMO</span>/Department of Rheumatology and Clinical Immunology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nikiphorou Elena </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33132334" target="_blank">Comorbidities and extra-articular manifestations in difficult-to-treat rheumatoid arthritis: different sides of the same coin?</a></div> <div> <span class="journal-title">RHEUMATOLOGY (UNITED KINGDOM)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1462-0324">1462-0324</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1462-0332">1462-0332</a>)</span>: <span class="journal-volume">62</span> <span class="journal-issue">5</span> <span class="page"> pp 1773-1779 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_NONE" title=" None "> <a style="color:blue" title="10.1093/rheumatology/keac584" target="_blank" href="https://doi.org/10.1093/rheumatology/keac584"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000871668600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000871668600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85149894565" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85149894565"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36205537" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36205537&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Pharmacology (medical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Rheumatology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 58</span> | Independent citation: 46 | Self citation: 12 | Unknown citation: 0 | Number of citations in WoS: 49 | Number of citations in Scopus:&nbsp;54 | WoS/Scopus assigned:&nbsp;56 | Number of citations with DOI:&nbsp;58 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33132334&sort=publishedYear,desc&sort=title"> Number of cited publications: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33132334</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="lastModified">Last Modified: 2026.07.02. 12:21 Zóra Kondor (SE_KK_Admin5_KZ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom Department of Rheumatology, Queen Elizabeth Hospital, London, United Kingdom Department of Genetics Cell-and Immunobiology, Semmelweis University, Budapest, Hungary Department of Rheumatology and Clinical Immunology, Department...</pre> </div></div>