The Kabachnik-Fields reaction is a multicomponent reaction that provides alpha-aminophosphonates
and phosphorus analogs of alpha-amino acids. While paramagnetic alpha- amino acids
are well known, to the best of our knowledge, this is the first report on paramagnetic.-aminophosphonate
syntheses. We present examples of nitroxide-containing.-aminophosphonates starting
from five- and six-membered paramagnetic aldehydes, a paramagnetic ketone, and five-
and six-membered paramagnetic amines. Starting from a beta-bromo-alpha,beta unsaturated
aldehyde, we constructed a pyrroline-nitroxide-condensed heterocycle with a phosphonate
ester substituent. [GRAPHICS]
