https://m2.mtmt.hu/ eng 2026-09-21 07:30 JournalArticle 33122418 VALIDATED true Protocol 0 false 2026-09-13T20:01:21.147+0000 2024-05-14T10:53:35.003+0000 2022-10-03T11:02:47.935+0000 true 10081959 Szalóky-Siki Ágnes /api/admin/10081959 Admin Ágnes Szalóky-Siki (SE_ÁOK_Transzlációs_Admin5_SZSÁ, admin) true 2026-02-19T12:16:56.973+0000 2026-02-19T12:16:56.973+0000 2022-10-20T07:29:09.540+0000 true 10069305 Kondor Zóra /api/admin/10069305 Admin Zóra Kondor (SE_KK_Admin5_KZ, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Kovács, Emőke Henrietta true true /api/journal/10024941 REVIEWED BMJ OPEN 2044-6055 2044-6055 true false 10024941 false 10024941 true 2044-6055 2044-6055 Journal FOREIGN 12 9 e063855 e063855 6 2022 The use of fibrinolytic therapy has been proposed in severe acute respiratory distress syndrome (ARDS). During the COVID-19 pandemic, anticoagulation has received special attention due to the frequent findings of microthrombi and fibrin deposits in the lungs and other organs. Therefore, the use of fibrinolysis has been regarded as a potential rescue therapy in these patients. In this prospective meta-analysis, we plan to synthesise evidence from ongoing clinical trials and thus assess whether fibrinolytic therapy can improve the ventilation/perfusion ratio in patients with severe COVID-19-caused ARDS as compared with standard of care.This protocol was registered in PROSPERO. All randomised controlled trials and prospective observational trials that compare fibrinolytic therapy with standard of care in adult patients with COVID-19 and define their primary or secondary outcome as improvement in oxygenation and/or gas exchange, or mortality will be considered eligible. Safety outcomes will include bleeding event rate and requirement for transfusion. Our search on 25 January 2022 identified five eligible ongoing clinical trials. A formal search of MEDLINE (via PubMed), Embase, CENTRAL will be performed every month to identify published results and to search for further trials that meet our eligibility criteria.This could be the first qualitative and quantitative synthesis summarising evidence of the efficacy and safety of fibrinolytic therapy in critically ill patients with COVID-19. We plan to publish our results in peer-reviewed journals.CRD42021285281. Funding 2019472 /api/funding/2019472 (K138816) Funder: NRDIO false true true 2022 true true true false true false GOLD 2026-09-13 true https://doi.org/10.1136/bmjopen-2022-063855 2 0 2 2 0 2 2 2 2 2 2 2 2 2 0 0 2 2 2 2 0 0 0 Folyóiratcikk Journal Article 24 2 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 2 2 2 2 Q1 false false false false 2022-10-02T12:25:05.248+0000 Aneszteziológiai és Intenzív Terápiás Klinika (SE / AOK / K); Doktori Iskola (SE); Pankreász Betegségek Részlege (SE / AOK / K); Transzlációs Medicina Intézet (PTE / ÁOK); Transzlációs Medicina Központ (SE / KSZE); Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 7 38 6 7 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 103626588 /api/authorship/103626588 Kovács, Emőke Henrietta [Kovács, Emőke Henrietta (Aneszteziológia), author] Department of Anesthesoiology and Intensiv Therapy (SU / FM / C); School of PhD Studies (SU); Centre for Translational Medicine (SU / KSZE) 1 0.143 true false false Author 10085428 /api/author/10085428 Emőke Henrietta Kovács (Aneszteziológia) Kovács Emőke Henrietta true true Kovács Emőke Henrietta true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 103626589 /api/authorship/103626589 Dembrovszky, Fanni [Dembrovszky, Fanni (Általános orvos), author] Institute for Translational Medicine (UP / UPMS); Centre for Translational Medicine (SU / KSZE) 2 0.143 false false false Author 10070652 /api/author/10070652 Fanni Dembrovszky (Általános orvos) Dembrovszky Fanni true true Dembrovszky Fanni true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 103626590 /api/authorship/103626590 Ocskay, Klementina [Ocskay, Klementina (Orvostudományok), author] Institute for Translational Medicine (UP / UPMS); Centre for Translational Medicine (SU / KSZE) 3 0.143 false false false Author 10074191 /api/author/10074191 Klementina Ocskay (Orvostudományok) Ocskay Klementina true true Ocskay Klementina true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 103626591 /api/authorship/103626591 Szabó, László [Szabó, László (Biostatisztika), author] Institute for Translational Medicine (UP / UPMS); Centre for Translational Medicine (SU / KSZE) 4 0.143 false false false Author 10081563 /api/author/10081563 László Szabó (Biostatisztika) Szabó László true true Szabó László true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 103626592 /api/authorship/103626592 Hegyi, Péter [Hegyi, Péter (Gasztroenterológia), author] Cardiovascular Center (SU / FM / C); Institute for Translational Medicine (UP / UPMS); Centre for Translational Medicine (SU / KSZE); Department of Pancreatic Diseases (SU / FM / C) 5 0.143 false false false Author 10002629 /api/author/10002629 Péter Hegyi (Gasztroenterológia) Hegyi Péter true 10002629 true Hegyi Péter true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 103626593 /api/authorship/103626593 Molnar, Zsolt [Molnár, Zsolt (Klinikai orvostud...), author] Department of Anesthesoiology and Intensiv Therapy (SU / FM / C); Centre for Translational Medicine (SU / KSZE) 6 0.143 false false false Author 10001298 /api/author/10001298 Zsolt Molnár (Klinikai orvostudományok - aneszteziológia és intenzív terápia) Molnár Zsolt true 10001298 true Molnar Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 103626594 /api/authorship/103626594 Tánczos, Krisztián ✉ [Tánczos, Krisztián (Aneszteziológia é...), author] Department of Anesthesoiology and Intensiv Therapy (SU / FM / C) 7 0.143 false true true Author 10021157 /api/author/10021157 Krisztián Tánczos (Aneszteziológia és intenzív terápia) Tánczos Krisztián true 10021157 true Tánczos Krisztián true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 21750013 /api/publicationidentifier/21750013 DOI: 10.1136/bmjopen-2022-063855 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1136/bmjopen-2022-063855 https://doi.org/10.1136/bmjopen-2022-063855 false true PublicationIdentifier 21852812 /api/publicationidentifier/21852812 WoS: 000863032400011 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000863032400011 https://www.webofscience.com/wos/woscc/full-record/000863032400011 true true PublicationIdentifier 21850605 /api/publicationidentifier/21850605 Scopus: 85138927765 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85138927765 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85138927765 false true PublicationIdentifier 21750012 /api/publicationidentifier/21750012 PubMed: 36167378 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36167378 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36167378&dopt=Abstract false true Keyword 3375201 /api/keyword/3375201 [Meta-analysis] true true SjrRating 11309423 /api/sjrrating/11309423 sjr:Q1 (2022) Scopus - Medicine (miscellaneous) BMJ OPEN 2044-6055 2044-6055 435 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 Scopus - Medicine (miscellaneous) true 2701 true Q1 DIRECT true true /api/publication/33122418 Kovács Emőke Henrietta et al. Effectiveness and safety of fibrinolytic therapy in critically ill patients with COVID-19 with ARDS: protocol for a prospective meta-analysis. (2022) BMJ OPEN 2044-6055 2044-6055 12 9<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10085428"><a href="/gui2/?type=authors&mode=browse&sel=10085428" target="_blank">Kovács Emőke Henrietta (<span class="authorship-author-name">Kovács Emőke Henrietta</span> <span class="authorAux-mtmt"> Aneszteziológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Anesthesoiology and Intensiv Therapy; <span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10070652"><a href="/gui2/?type=authors&mode=browse&sel=10070652" target="_blank">Dembrovszky Fanni (<span class="authorship-author-name">Dembrovszky Fanni</span> <span class="authorAux-mtmt"> Általános orvos</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074191"><a href="/gui2/?type=authors&mode=browse&sel=10074191" target="_blank">Ocskay Klementina (<span class="authorship-author-name">Ocskay Klementina</span> <span class="authorAux-mtmt"> Orvostudományok</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10081563"><a href="/gui2/?type=authors&mode=browse&sel=10081563" target="_blank">Szabó László (<span class="authorship-author-name">Szabó László</span> <span class="authorAux-mtmt"> Biostatisztika</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Péter (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center; <span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Pancreatic Diseases</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001298"><a href="/gui2/?type=authors&mode=browse&sel=10001298" target="_blank">Molnar Zsolt (<span class="authorship-author-name">Molnár Zsolt</span> <span class="authorAux-mtmt"> Klinikai orvostudományok - aneszteziológia és i...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Anesthesoiology and Intensiv Therapy; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021157"><a href="/gui2/?type=authors&mode=browse&sel=10021157" target="_blank">Tánczos Krisztián ✉ (<span class="authorship-author-name">Tánczos Krisztián</span> <span class="authorAux-mtmt"> Aneszteziológia és intenzív terápia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Anesthesoiology and Intensiv Therapy</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33122418" target="_blank">Effectiveness and safety of fibrinolytic therapy in critically ill patients with COVID-19 with ARDS: protocol for a prospective meta-analysis</a></div> <div> <span class="journal-title">BMJ OPEN</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2044-6055">2044-6055</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2044-6055">2044-6055</a>)</span>: <span class="journal-volume">12</span> <span class="journal-issue">9</span> <span class="page"> Paper e063855. 6 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1136/bmjopen-2022-063855" target="_blank" href="https://doi.org/10.1136/bmjopen-2022-063855"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000863032400011" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000863032400011"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85138927765" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85138927765"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36167378" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36167378&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 2</span> | Independent citation: 2 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 2 | Number of citations in Scopus:&nbsp;2 | WoS/Scopus assigned:&nbsp;2 | Number of citations with DOI:&nbsp;2 </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33122418</span> | <span class="status-data status-VALIDATED"> Validated </span> Core | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (K138816) Funder: NRDIO </div> <div class="lastModified">Last Modified: 2024.05.14. 12:53 Róbert Milánkovics (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Protocol</pre> </div></div>