(NVKP-16-1-2016-0017 National Heart Program) Funder: NRDIO
Subjects:
Cardiovascular system
This review aims to summarise new approaches in SARS-CoV-2-related research in cardiology.
We provide a head-to-head comparison of models, such as animal research and human
pluripotent stem cells, to investigate the pathomechanisms of COVID-19 and find an
efficient therapy. In vivo methods were useful for studying systemic processes of
the disease; however, due to differences in animal and human biology, the clinical
translation of the results remains a complex task. In vitro stem cell research makes
cellular events more observable and effective for finding new drugs and therapies
for COVID-19, including the use of stem cells. Furthermore, multicellular 3D organoids
even make it possible to observe the effects of drugs to treat SARS-CoV-2 infection
in human organ models.
