NTP-NFTÖ-21-B(Nemzet Fiatal Tehetségeiért Ösztöndíj 2021) Funder: Ministry of Human
Capacities
Subjects:
Dentistry, oral surgery and medicine
ABSTRACT The aim of this review is to evaluate the possibility of delivering a silver-acid
complex via a Trojan-horse mechanism for managing periodontits. We theroised that
the complex could be an effective treatment option for bacterial inflammatory processes
in the oral cavity. Searches were conducted using MEDLINE, Embase, Web of Science
Core Collection, and Google Scholar search engines. We also reviewed several reference
lists of the included studies or relevant reviews identified by the search. By using
Medical Subject Headings (MeSH) terminology, a comprehensive search was performed
for the following keywords: silver, folic acid, periodontitis, macrophages, Trojan-horse
mechanism, toxicity, and targeting. Using the keywords mentioned earlier, we selected
110 articles and after appropriate elimination the review was written based on 37
papers. Accordingly the we noted that silver isons were an effective approach to kill
oral pathogens. Secondly the Trojan-horse mechanism. could be used by macrophages
(as the Trojan horse) to deliver silver ions in large quantities to the inflammatory
focus to kill the periodontopathogens. The Trojan-horse mechanism has never been described
in the field of dentistry before. The proposed novel approach using the principle
of Trojan Horse delivery of drugs/chemicals could be used to manage oral inflammatory
conditions. This method can be used to supplement regular treatments.
