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      <abstractText>Despite great enthusiasm towards immunotherapy, reliable biomarkers are still lacking. The importance of subsets based on human papillomavirus (HPV) status is supported by a growing body of evidence. However, role of other possible subgroups such as anatomic localization of primary tumor remains controversial. Our objective was to investigate immune cell infiltrate and checkpoint inhibitor proteins in above-mentioned head and neck cancer subsets. Archival tumor samples of 106 laryngeal, oropharyngeal, and hypopharyngeal cancer patients were stained with PD-L1, PD-L2, PD-1, and CTLA-4 antibodies. Proportion of tumor-infiltrating lymphocytes was assessed as well. In HPV-negative tumors, PD-L1 immune cell positivity was associated with better disease-specific survival. PD-L1 expression on immune cells correlated with improved disease-specific survival in laryngeal tumors. Furthermore, PD-L1 immune cell positivity correlated with CTLA-4 expression on immune cells and it was accompanied by high tumor-infiltrating lymphocyte rate. PD-L1 expression on tumor cells and PD-1 status showed strong correlation in all patients and in oropharyngeal and laryngeal localization, but not in hypopharynx. HPV-negative oropharyngeal cancers showed negative PD-L1 status on tumor cells. CTLA-4 positivity was observed in 49.5% and 20.6% on immune cells and on tumor cells, respectively. We concluded that PD-L1 expression on immune cells indicates better prognosis in laryngeal squamous cell carcinoma and in HPV-negative head and neck squamous cell carcinoma. We have not found any essential differences between anatomic subgroups. A possibly distinct role of hypopharyngeal localization regarding immune activity requires further clarification.</abstractText>
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      <label>Birtalan E et al. Expression of PD-L1 on Immune Cells Shows Better Prognosis in Laryngeal, Oropharygeal, and Hypopharyngeal Cancer. (2018) APPLIED IMMUNOHISTOCHEMISTRY &amp; MOLECULAR MORPHOLOGY 1541-2016 1533-4058 26 7 e79-e85</label><template>&lt;div class=&quot;JournalArticle Publication short-list&quot;&gt; &lt;div class=&quot;authors&quot;&gt; &lt;span class=&quot;author-name&quot; mtid=&quot;10046517&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10046517&quot; target=&quot;_blank&quot;&gt;Birtalan, E ✉&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10038518&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10038518&quot; target=&quot;_blank&quot;&gt;Dános, K&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10059086&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10059086&quot; target=&quot;_blank&quot;&gt;Gurbi, B&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; 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																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10038518&quot; target=&quot;_blank&quot;&gt;Dános K
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							&lt;span class=&quot;author-name&quot; mtid=&quot;10059086&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10059086&quot; target=&quot;_blank&quot;&gt;Gurbi B
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Gurbi Bianka&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; célzott daganatterápia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/&lt;span title=&quot;Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet&quot;&gt;OVMBPI&lt;/span&gt;/MTA-SE Patobiokémiai Kutatócsoport&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10036137&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10036137&quot; target=&quot;_blank&quot;&gt;Brauswetter D
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Brauswetter Diána&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; patobiokémia&lt;/span&gt;)
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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/&lt;span title=&quot;Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet&quot;&gt;OVMBPI&lt;/span&gt;/MTA-SE Patobiokémiai Kutatócsoport&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10023806&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10023806&quot; target=&quot;_blank&quot;&gt;Halász J
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Halász Judit&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; máj patologia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/II. Sz. Patológiai Intézet&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; &gt;Kalocsáné Piurko V
    &lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10048444&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10048444&quot; target=&quot;_blank&quot;&gt;Ács B
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Ács Balázs&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; patológia, onkológia&lt;/span&gt;)
			&lt;/a&gt;
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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/II. Sz. Patológiai Intézet&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; &gt;Antal B
    &lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; &gt;Mihályi R
    &lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10063540&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10063540&quot; target=&quot;_blank&quot;&gt;Pató A
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Pató Anna Terézia&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Élettan&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;Semmelweis Egyetem; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/Általános Orvostudományi Kar&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10023612&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10023612&quot; target=&quot;_blank&quot;&gt;Fent Z
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Fent Zoltán&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; fül-orr-gégészet, foniátria, csecsemő és gyerme...&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;221&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=221&quot; target=&quot;_blank&quot;&gt;Polony G
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Polony Gábor&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Fül-orr-gégészet&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10000584&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10000584&quot; target=&quot;_blank&quot;&gt;Tímár J
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Tímár József&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Rákkutatás, daganatpathológia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/II. Sz. Patológiai Intézet&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10010129&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10010129&quot; target=&quot;_blank&quot;&gt;Tamás L
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Tamás László&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Fül-orr-gégészet&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika&lt;/span&gt;

				    &lt;/div&gt;
&lt;/div&gt;
&lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;3310542&quot; target=&quot;_blank&quot;&gt;Expression of PD-L1 on Immune Cells Shows Better Prognosis in Laryngeal, Oropharygeal, and Hypopharyngeal Cancer&lt;/a&gt;&lt;/div&gt;    &lt;div&gt;		&lt;span class=&quot;journal-title&quot;&gt;APPLIED IMMUNOHISTOCHEMISTRY &amp; MOLECULAR MORPHOLOGY&lt;/span&gt;

        &lt;span class=&quot;journal-issn&quot;&gt;(&lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/1541-2016&quot;&gt;1541-2016&lt;/a&gt; &lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/1533-4058&quot;&gt;1533-4058&lt;/a&gt;)&lt;/span&gt;:
		&lt;span class=&quot;journal-volume&quot;&gt;26&lt;/span&gt; &lt;span class=&quot;journal-issue&quot;&gt;7&lt;/span&gt;
&lt;span class=&quot;page&quot;&gt;
	pp e79-e85
			
&lt;/span&gt;		 &lt;span class=&quot;year&quot;&gt;(2018)&lt;/span&gt;  
    &lt;/div&gt;
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									DOI
							&lt;/a&gt;
						&lt;/span&gt;
						&lt;span class=&quot;id identifier oa_RESTRICTED&quot; title=&quot;	Korlátozott
&quot;&gt;
							
							&lt;a style=&quot;color:blue&quot; title=&quot;6415&quot; target=&quot;_blank&quot; href=&quot;https://repo.lib.semmelweis.hu/handle/123456789/6415&quot;&gt;
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	&lt;OnlyViewableByAuthor&gt;&lt;div class=&quot;ratings&quot;&gt;
				&lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Medical Laboratory Technology&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;Q1&lt;/div&gt;
				&lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Histology&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;Q2&lt;/div&gt;
				&lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Pathology and Forensic Medicine&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;Q2&lt;/div&gt;
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	&lt;div class=&quot;publication-citation&quot; style=&quot;margin-left: 0.5cm;&quot;&gt;
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		| Független: 37
		| Függő: 2
		| Nem jelölt: 0
		| WoS jelölt: 38 
		|  Scopus jelölt:&amp;nbsp;38 
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		|  DOI jelölt:&amp;nbsp;38 
		
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    &lt;div class=&quot;mtid&quot;&gt;&lt;span class=&quot;long-pub-mtid&quot;&gt;Közlemény: 3310542&lt;/span&gt;
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	&lt;span class=&quot;oldId&quot;&gt;Régi azonosító: 3310542&lt;/span&gt; | 
	
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      		| &lt;span class=&quot;pub-category&quot;&gt;Tudományos&lt;/span&gt;
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&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2024.05.30. 14:47 Gere Tamásné (SE_KK_Admin5_GT, admin)
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	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Cited By :35            
            Export Date: 24 November 2024            
            CODEN: AIMMF&lt;/pre&gt;
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