https://m2.mtmt.hu/ eng 2026-04-15 01:20 JournalArticle 33093902 VALIDATED true Department of Surgery, Transplantology and Gastroenterology, Semmelweis University, Ülloi út 78., Budapest, H-1082, Hungary Research Centre for Natural Sciences, Institute of Materials and Environmental Chemistry, Magyar tudósok körútja 2., Budapest, H-1117, Hungary Institute of Genetics and Biotechnology, Hungarian University of Agriculture and Life Sciences, Ménesi út 44., Budapest, H-1118, Hungary Institute of Animal Physiology and Nutrition, Hungarian University of Agriculture and Life Sciences, Gesztenyés út 1., Herceghalom, H-2053, Hungary Department of Laboratory Medicine, Semmelweis University, Ülloi út 78/a., Budapest, H-1089, Hungary Department of Surgical Research and Techniques, The Heart and Vascular Center, Semmelweis University, Nagyvárad tér 4., Budapest, H-1089, Hungary Export Date: 28 October 2022 Correspondence Address: Hagymási, K.; Department of Surgery, Ülloi út 78., Hungary; email: hagymasi.krisztina@med.semmelweis-univ.hu 0 false 2025-12-31T19:03:19.507+0000 2023-01-26T07:51:36.016+0000 2022-09-15T08:18:22.279+0000 true 10053044 Sallai-Tóth László /api/admin/10053044 Admin true 10053044 2026-01-12T10:49:05.286+0000 2026-01-12T10:49:05.286+0000 2022-10-05T11:08:14.986+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Hagymási, K. Altered element homeostasis and transmethylation ability in short-term polyphenol rich supplementation in hyperlipidemic animal model true true /api/journal/22 REVIEWED true true 22 false 22 true 0139-3006 1588-2535 Journal FOREIGN 51 3 371 381 371 11 2022 Abstract Non-alcoholic fatty liver disease is one of the most common chronic liver diseases with unclarified pathomechanism and without evidence-proven therapy. Dietary polyphenols, targeting oxidative stress, are at the center of investigations. Our aim was to examine the effects of a polyphenol rich extract on metal element homeostasis and transmethylation ability in non-alcoholic fatty liver model. A ten-day rat model was used (control group, hyperlipidemic group with fat-rich diet, hyperlipidemic group with fat-rich diet and polyphenol supplementation, N = 8 in each group). The hyperlipidemic diet increased the concentration of the majority of the elements with significantly higher contents of B, Co, Cu, Fe, Mg, Mn, Na, Ni, P, Se, Si, and Zn in the liver. Further elevation of Al, Pb, and Sn concentrations could be observed in polyphenol supplemented animals. The polyphenol supplement unexpectedly decreased the transmethylation ability of the liver (132.00 vs. 114.15 vs. 92.25 HCHO μg g−1) further. The results emphasize the possible role of altered metal and non-metal element concentrations and decreased transmethylation ability in the pathomechanism of fatty liver disease. Dietary supplementation with natural compounds may have undesirable effect as well, there is the necessity to improve the efficacy of polyphenol formulations because of their low oral bioavailability. true true 2022 false true true false true false GREEN 2025-12-31 true http://real.mtak.hu/148701 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 9 Q3 false 10015320,10000068,10008492 false false false 2022-10-04T11:08:14.421+0000 Acta Alimentaria szerkesztősége (Kiadók / MTA KFB); Anyag- és Környezetkémiai Intézet (TTK); Kísérletes és Sebészeti Műtéttani Tanszék (SE / AOK / K); Laboratóriumi Medicina Intézet (SE / AOK / I); Sebészeti, Transzplantációs és Gasztroenterológ... (SE / AOK / K); Takarmányozás-élettani csoport (MATE / ÉTI / TTÉT) 7 62 6 7 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 103401913 /api/authorship/103401913 1 0.143 true false true Author 10000068 /api/author/10000068 Hagymási Krisztina true 10000068 true Hagymási K. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103401914 /api/authorship/103401914 2 0.143 false false false Author 10002938 /api/author/10002938 Szentmihályi Klára true 10002938 true Szentmihályi K. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103401915 /api/authorship/103401915 3 0.143 false false false Author 10013002 /api/author/10013002 May Zoltán true 10013002 true May Z. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103401916 /api/authorship/103401916 4 0.143 false false false Author 10008492 /api/author/10008492 Sárdi Éva true 10008492 true Sárdi É true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103401917 /api/authorship/103401917 5 0.143 false false false Author 10001814 /api/author/10001814 Fébel Hedvig true 10001814 true Fébel H. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103401918 /api/authorship/103401918 6 0.143 false false false Author 10028001 /api/author/10028001 Kocsis Ibolya DUPLUM true 10028001 true Kocsis I. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103401919 /api/authorship/103401919 7 0.143 false true false Author 10015320 /api/author/10015320 Blázovics Anna true 10015320 true Blázovics A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true Institute 21499 /api/institute/21499 0 false false true Acta Alimentaria szerkesztősége Editorial office of Acta Alimentaria true true PublicationIdentifier 21681423 /api/publicationidentifier/21681423 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true NONE IDENTICAL 10.1556/066.2022.00053 https://doi.org/10.1556/066.2022.00053 false true PublicationIdentifier 21682264 /api/publicationidentifier/21682264 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL http://real.mtak.hu/@@@ true true 36 true GREEN true 148701 http://real.mtak.hu/148701 false true PublicationIdentifier 22936798 /api/publicationidentifier/22936798 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000904938000006 https://www.webofscience.com/wos/woscc/full-record/000904938000006 true true PublicationIdentifier 21762427 /api/publicationidentifier/21762427 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85137977059 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85137977059 true true SjrRating 11274852 /api/sjrrating/11274852 239 0.74 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1106 /api/classificationexternal/1106 true 1106 true Q3 DIRECT true true /api/publication/33093902 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10000068"><a href="/gui2/?type=authors&mode=browse&sel=10000068" target="_blank">Hagymási K. ✉ (<span class="authorship-author-name">Hagymási Krisztina</span> <span class="authorAux-mtmt"> Orvostudomány, gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Sebészeti, Transzplantációs és Gasztroenterológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002938"><a href="/gui2/?type=authors&mode=browse&sel=10002938" target="_blank">Szentmihályi K. (<span class="authorship-author-name">Szentmihályi Klára</span> <span class="authorAux-mtmt"> Élelmiszertudomány</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Materials and Environmental Chemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013002"><a href="/gui2/?type=authors&mode=browse&sel=10013002" target="_blank">May Z. (<span class="authorship-author-name">May Zoltán</span> <span class="authorAux-mtmt"> Szervetlen analitikai kémia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Materials and Environmental Chemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008492"><a href="/gui2/?type=authors&mode=browse&sel=10008492" target="_blank">Sárdi É (<span class="authorship-author-name">Sárdi Éva</span> <span class="authorAux-mtmt"> Rezisztencia biokémia, analitika</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001814"><a href="/gui2/?type=authors&mode=browse&sel=10001814" target="_blank">Fébel H. (<span class="authorship-author-name">Fébel Hedvig</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Hungarian University of Agriculture and Life Sciences">HUALS</span>/<span title="Institute of Physiology and Nutrition">IPN</span>/<span title="Department of Nutrition and Nutritional Physiology">DNNP</span>/Nutritional Physiology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028001"><a href="/gui2/?type=authors&mode=browse&sel=10028001" target="_blank">Kocsis I. (<span class="authorship-author-name">Kocsis Ibolya</span> <span class="authorAux-mtmt"> laboratóriumi diagnosztika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Laboratory Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015320"><a href="/gui2/?type=authors&mode=browse&sel=10015320" target="_blank">Blázovics A. (<span class="authorship-author-name">Blázovics Anna</span> <span class="authorAux-mtmt"> Hepatológiai és gastroenterológiai kutatások</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Experimental and Clinical Surgery</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33093902" target="_blank">Altered element homeostasis and transmethylation ability in short-term polyphenol rich supplementation in hyperlipidemic animal model</a></div> <div> <span class="journal-title">ACTA ALIMENTARIA: AN INTERNATIONAL JOURNAL OF FOOD SCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0139-3006">0139-3006</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1588-2535">1588-2535</a>)</span>: <span class="journal-volume">51</span> <span class="journal-issue">3</span> <span class="page"> pp 371-381 </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_NONE" title=" None "> <a style="color:blue" title="10.1556/066.2022.00053" target="_blank" href="https://doi.org/10.1556/066.2022.00053"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="148701" target="_blank" href="http://real.mtak.hu/148701"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000904938000006" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000904938000006"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85137977059" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85137977059"> Scopus </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Food Science&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33093902&sort=publishedYear,desc&sort=title"> Number of cited publications: 9 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33093902</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="special-affiliations"> Special affiliation: Editorial office of Acta Alimentaria </div> <div class="lastModified">Last Modified: 2023.01.26. 08:51 Márta Molnár-Taga (SE 4-es admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Surgery, Transplantology and Gastroenterology, Semmelweis University, Ülloi út 78., Budapest, H-1082, Hungary Research Centre for Natural Sciences, Institute of Materials and Environmental Chemistry, Magyar tudósok körútja 2., Budapest, H-1117, Hungary Institute of Genetics and Biotechnology, Hungarian University of Agriculture and L...</pre> </div></div>