{ "labelLang" : "hun", "responseDate" : "2024-03-28 18:08", "content" : { "otype" : "JournalArticle", "mtid" : 33569721, "status" : "APPROVED", "published" : true, "comment" : "Export Date: 17 January 2023 \n CODEN: MITOC", "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2023-01-17T12:44:02.533+0000", "lastModified" : "2023-01-17T12:11:01.247+0000", "created" : "2023-01-17T11:40:27.548+0000", "creator" : { "otype" : "Admin", "mtid" : 10081634, "link" : "/api/admin/10081634", "label" : "Berger-Kéry Orsolya (SZBK 5admin)", "familyName" : "Berger-Kéry", "givenName" : "Orsolya", "published" : true, "snippet" : true }, "lastDuplumOK" : "2023-01-17T12:42:59.627+0000", "lastDuplumSearch" : "2023-01-17T12:42:59.627+0000", "core" : false, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Szakcikk (Folyóiratcikk)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Desler, C.", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 106333820, "link" : "/api/authorship/106333820", "label" : "Desler, C.", "listPosition" : 1, "share" : 0.14285715, "first" : true, "last" : false, "corresponding" : false, "familyName" : "Desler", "givenName" : "C.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 106333821, "link" : "/api/authorship/106333821", "label" : "Durhuus, J.A.", "listPosition" : 2, "share" : 0.14285715, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Durhuus", "givenName" : "J.A.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 106333822, "link" : "/api/authorship/106333822", "label" : "Hansen, T.L.-L.", "listPosition" : 3, "share" : 0.14285715, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Hansen", "givenName" : "T.L.-L.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 106333823, "link" : "/api/authorship/106333823", "label" : "Anugula, S.", "listPosition" : 4, "share" : 0.14285715, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Anugula", "givenName" : "S.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 106333824, "link" : "/api/authorship/106333824", "label" : "Zelander, N.T.", "listPosition" : 5, "share" : 0.14285715, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Zelander", "givenName" : "N.T.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 106333825, "link" : "/api/authorship/106333825", "label" : "Bøggild, S.", "listPosition" : 6, "share" : 0.14285715, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Bøggild", "givenName" : "S.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 106333826, "link" : "/api/authorship/106333826", "label" : "Rasmussen, L.J.", "listPosition" : 7, "share" : 0.14285715, "first" : false, "last" : true, "corresponding" : false, "familyName" : "Rasmussen", "givenName" : "L.J.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true } ], "title" : "Partial inhibition of mitochondrial-linked pyrimidine synthesis increases tumorigenic potential and lysosome accumulation", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 22859178, "link" : "/api/publicationidentifier/22859178", "label" : "DOI: 10.1016/j.mito.2022.03.005", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "idValue" : "10.1016/j.mito.2022.03.005", "realUrl" : "https://doi.org/10.1016/j.mito.2022.03.005", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 22859179, "link" : "/api/publicationidentifier/22859179", "label" : "WoS: 000791279800007", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "https://www.webofscience.com/wos/woscc/full-record/WOS:@@@", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "idValue" : "000791279800007", "realUrl" : "https://www.webofscience.com/wos/woscc/full-record/WOS:000791279800007", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 22859177, "link" : "/api/publicationidentifier/22859177", "label" : "Scopus: 85127076106", "source" : { "otype" : "PlainSource", "mtid" : 3, "link" : "/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "idValue" : "85127076106", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85127076106", "published" : false, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 10000896, "link" : "/api/journal/10000896", "label" : "MITOCHONDRION 1567-7249 1872-8278", "pIssn" : "1567-7249", "eIssn" : "1872-8278", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 10000896, "snippet" : true }, "volume" : "64", "firstPage" : "73", "lastPage" : "81", "firstPageOrInternalIdForSort" : "73", "pageLength" : 9, "publishedYear" : 2022, "abstractText" : "The correlation between mitochondrial function and oncogenesis is complex and is not fully understood. Here we determine the importance of mitochondrial-linked pyrimidine synthesis for the aggressiveness of cancer cells. The enzyme dihydroorotate dehydrogenase (DHODH) links oxidative phosphorylation to de novo synthesis of pyrimidines. We demonstrate that an inhibition of DHODH results in a respiration-independent significant increase of anchorage-independent growth but does not affect DNA repair ability. Instead, we show an autophagy-independent increase of lysosomes. The results of this study suggest that inhibition of mitochondrial-linked pyrimidine synthesis in cancer cells results in a more aggressive tumor phenotype. © 2022", "keywords" : [ { "otype" : "Keyword", "mtid" : 65, "link" : "/api/keyword/65", "label" : "Humans", "published" : true, "oldId" : 65, "snippet" : true }, { "otype" : "Keyword", "mtid" : 651, "link" : "/api/keyword/651", "label" : "GENETICS", "published" : true, "oldId" : 651, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1699, "link" : "/api/keyword/1699", "label" : "ARTICLE", "published" : true, "oldId" : 1699, "snippet" : true }, { "otype" : "Keyword", "mtid" : 3122, "link" : "/api/keyword/3122", "label" : "human", "published" : true, "oldId" : 3122, "snippet" : true }, { "otype" : "Keyword", "mtid" : 4608, "link" : "/api/keyword/4608", "label" : "controlled study", "published" : true, "oldId" : 4608, "snippet" : true }, { "otype" : "Keyword", "mtid" : 5016, "link" : "/api/keyword/5016", "label" : "Mitochondria", "published" : true, "oldId" : 5016, "snippet" : true }, { "otype" : "Keyword", "mtid" : 6683, "link" : "/api/keyword/6683", "label" : "enzyme inhibition", "published" : true, "oldId" : 6683, "snippet" : true }, { "otype" : "Keyword", "mtid" : 7986, "link" : "/api/keyword/7986", "label" : "DNA Repair", "published" : true, "oldId" : 7986, "snippet" : true }, { "otype" : "Keyword", "mtid" : 7986, "link" : "/api/keyword/7986", "label" : "DNA Repair", "published" : true, "oldId" : 7986, "snippet" : true }, { "otype" : "Keyword", "mtid" : 13681, "link" : "/api/keyword/13681", "label" : "Lysosomes", "published" : true, "oldId" : 13681, "snippet" : true }, { "otype" : "Keyword", "mtid" : 13979, "link" : "/api/keyword/13979", "label" : "human cell", "published" : true, "oldId" : 13979, "snippet" : true }, { "otype" : "Keyword", "mtid" : 14614, "link" : "/api/keyword/14614", "label" : "cell aggregation", "published" : true, "oldId" : 14614, "snippet" : true }, { "otype" : "Keyword", "mtid" : 15058, "link" : "/api/keyword/15058", "label" : "lysosome", "published" : true, "oldId" : 15058, "snippet" : true }, { "otype" : "Keyword", "mtid" : 15058, "link" : "/api/keyword/15058", "label" : "lysosome", "published" : true, "oldId" : 15058, "snippet" : true }, { "otype" : "Keyword", "mtid" : 18308, "link" : "/api/keyword/18308", "label" : "pyrimidines", "published" : true, "oldId" : 18308, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1000863, "link" : "/api/keyword/1000863", "label" : "tumor growth", "published" : true, "oldId" : 1000863, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1007711, "link" : "/api/keyword/1007711", "label" : "Carcinogenicity", "published" : true, "oldId" : 1007711, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1009775, "link" : "/api/keyword/1009775", "label" : "CARCINOGENESIS", "published" : true, "oldId" : 1009775, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1009775, "link" : "/api/keyword/1009775", "label" : "CARCINOGENESIS", "published" : true, "oldId" : 1009775, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1011382, "link" : "/api/keyword/1011382", "label" : "pyrimidine derivative", "published" : true, "oldId" : 1011382, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1013336, "link" : "/api/keyword/1013336", "label" : "oxidoreductase", "published" : true, "oldId" : 1013336, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1028891, "link" : "/api/keyword/1028891", "label" : "cancer cell", "published" : true, "oldId" : 1028891, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1068556, "link" : "/api/keyword/1068556", "label" : "Tumorigenesis", "published" : true, "oldId" : 1068556, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1071886, "link" : "/api/keyword/1071886", "label" : "pyrimidine synthesis", "published" : true, "oldId" : 1071886, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1084165, "link" : "/api/keyword/1084165", "label" : "oxidative phosphorylation", "published" : true, "oldId" : 1084165, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1139423, "link" : "/api/keyword/1139423", "label" : "anchorage independent growth", "published" : true, "oldId" : 1139423, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1260884, "link" : "/api/keyword/1260884", "label" : "mitochondrial dynamics", "published" : true, "oldId" : 1260884, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1505291, "link" : "/api/keyword/1505291", "label" : "dihydroorotate dehydrogenase", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1505291, "link" : "/api/keyword/1505291", "label" : "dihydroorotate dehydrogenase", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1505291, "link" : "/api/keyword/1505291", "label" : "dihydroorotate dehydrogenase", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1511994, "link" : "/api/keyword/1511994", "label" : "Oxidoreductases Acting on CH-CH Group Donors", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1524500, "link" : "/api/keyword/1524500", "label" : "pyrimidine", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1524500, "link" : "/api/keyword/1524500", "label" : "pyrimidine", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1962441, "link" : "/api/keyword/1962441", "label" : "autophagy (cellular)", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 2959281, "link" : "/api/keyword/2959281", "label" : "Lysosome increase", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 2959282, "link" : "/api/keyword/2959282", "label" : "Mitochondrial-linked pyrimidine synthesis", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2023, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2023-01-17", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 1, "citedCount" : 1, "ratings" : [ { "otype" : "SjrRating", "mtid" : 11284231, "link" : "/api/sjrrating/11284231", "label" : "sjr:Q2 (2022) Scopus - Cell Biology MITOCHONDRION 1567-7249", "listPos" : 112, "rankValue" : 0.49, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 1307, "link" : "/api/classificationexternal/1307", "label" : "Scopus - Cell Biology", "published" : true, "oldId" : 1307, "snippet" : true }, "ranking" : "Q2", "calculation" : "FROM_LAST_YEAR", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q2", "hasCitationDuplums" : false, "userChangeableUntil" : "2023-04-17T11:11:01.000+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 20, "ownerInstituteCount" : 67, "directInstituteCount" : 0, "authorCount" : 7, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/33569721", "label" : "Desler C. et al. Partial inhibition of mitochondrial-linked pyrimidine synthesis increases tumorigenic potential and lysosome accumulation. (2022) MITOCHONDRION 1567-7249 1872-8278 64 73-81", "template" : "