https://m2.mtmt.hu/ hun 2026-09-12 00:49 JournalArticle 33091182 VALIDATED true Department of Measurement and Information Systems, Budapest University of Technology and EconomicsBudapest H-1111, Hungary Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States Export Date: 22 September 2022 0 false 2026-05-22T03:51:25.326+0000 2026-02-23T13:15:12.342+0000 2022-09-13T10:19:35.183+0000 true 10062733 Bruncsics Bence /api/author/10062733 Author Bruncsics Bence (Informatika) true 10062733 2026-02-23T13:15:12.714+0000 2026-02-23T13:15:12.714+0000 2022-09-30T09:34:12.658+0000 true 10072271 Andódy Katalin /api/admin/10072271 Admin Andódy Katalin (BME admin4) true 2022-10-22T02:00:12.056+0000 true 10067876 Ladányi Gusztáv /api/admin/10067876 Admin Ladányi Gusztáv (MTMT API user, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Bruncsics, Bence true true /api/journal/10015678 REVIEWED NATURE COMMUNICATIONS 2041-1723 true false 10015678 false 10015678 true 2041-1723 Journal FOREIGN 13 1 5029 5029 13 2022 Arising through multiple binding elements, multivalency can specify the avidity, duration, cooperativity, and selectivity of biomolecular interactions, but quantitative prediction and design of these properties has remained challenging. Here we present MVsim , an application suite built around a configurational network model of multivalency to facilitate the quantification, design, and mechanistic evaluation of multivalent binding phenomena through a simple graphical user interface. To demonstrate the utility and versatility of MVsim , we first show that both monospecific and multispecific multivalent ligand-receptor interactions, with their noncanonical binding kinetics, can be accurately simulated. Further, to illustrate the conceptual insights into multivalent systems that MVsim can provide, we apply it to quantitatively predict the ultrasensitivity and performance of multivalent-encoded protein logic gates, evaluate the inherent programmability of multispecificity for selective receptor targeting, and extract rate constants of conformational switching for the SARS-CoV-2 spike protein and model its binding to ACE2 as well as multivalent inhibitors of this interaction. MVsim and instructional tutorials are freely available at https://sarkarlab.github.io/MVsim/ . Funding 2064409 /api/funding/2064409 (Artificial Intelligence National Laboratory Programme) Támogató: NKFIH false true true INTERNATIONAL 2022 true true true false true false GOLD 2026-05-22 true https://doi.org/10.1038/s41467-022-32496-6 8 0 8 6 0 8 8 7 2 7 7 5 5 6 2 0 8 6 8 6 0 2 2 Folyóiratcikk Journal Article 24 8 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 1 1 1 1 2023 0 2 1 2 1 2024 0 2 1 2 1 2025 0 2 2 2 2 2026 0 1 1 1 1 D1 A nemzetközi false 10062733 false false false 2022-09-29T09:34:12.404+0000 Méréstechnika és Információs Rendszerek Tanszék (BME / VIK) 1 6 1 3 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 103386781 /api/authorship/103386781 Bruncsics, Bence [Bruncsics, Bence (Informatika), szerző] Méréstechnika és Információs Rendszerek Tanszék (BME / VIK) 1 0.33333334 true false false Author 10062733 /api/author/10062733 Bruncsics Bence (Informatika) Bruncsics Bence true 10062733 true Bruncsics Bence true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 103386782 /api/authorship/103386782 Errington, Wesley J. 2 0.33333334 false false false Errington Wesley J. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 103386783 /api/authorship/103386783 Sarkar, Casim A. ✉ 3 0.333 false true true Sarkar Casim A. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 21674846 /api/publicationidentifier/21674846 DOI: 10.1038/s41467-022-32496-6 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1038/s41467-022-32496-6 https://doi.org/10.1038/s41467-022-32496-6 false true PublicationIdentifier 21715875 /api/publicationidentifier/21715875 WoS: 000851930300019 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000851930300019 https://www.webofscience.com/wos/woscc/full-record/000851930300019 false true PublicationIdentifier 21715874 /api/publicationidentifier/21715874 Scopus: 85137312310 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85137312310 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85137312310 false true PublicationIdentifier 21736379 /api/publicationidentifier/21736379 PubMed: 36068204 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36068204 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36068204&dopt=Abstract false true PublicationIdentifier 21674847 /api/publicationidentifier/21674847 Egyéb URL: https://www.nature.com/articles/s41467-022-32496-6 PlainSource 40 /api/publicationsource/40 Egyéb URL PublicationSourceType 10006 /api/publicationsourcetype/10006 Link true true true Egyéb URL Other URL @@@ true true 40 true https://www.nature.com/articles/s41467-022-32496-6 https://www.nature.com/articles/s41467-022-32496-6 false true Classification 10807 /api/classification/10807 Műszaki és technológiai tudományok true true MtaRating 11551153 /api/mtarating/11551153 IX. 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(2022) NATURE COMMUNICATIONS 2041-1723 13 1<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10062733"><a href="/gui2/?type=authors&mode=browse&sel=10062733" target="_blank">Bruncsics Bence (<span class="authorship-author-name">Bruncsics Bence</span> <span class="authorAux-mtmt"> Informatika</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Villamosmérnöki és Informatikai Kar">VIK</span>/Méréstechnika és Információs Rendszerek Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Errington Wesley J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sarkar Casim A. ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33091182" target="_blank">MVsim is a toolset for quantifying and designing multivalent interactions</a></div> <div> <span class="journal-title">NATURE COMMUNICATIONS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2041-1723">2041-1723</a>)</span>: <span class="journal-volume">13</span> <span class="journal-issue">1</span> <span class="page"> Paper 5029. 13 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41467-022-32496-6" target="_blank" href="https://doi.org/10.1038/s41467-022-32496-6"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000851930300019" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000851930300019"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85137312310" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85137312310"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36068204" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36068204&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://www.nature.com/articles/s41467-022-32496-6" target="_blank" href="https://www.nature.com/articles/s41467-022-32496-6"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Chemistry (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physics and Astronomy (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Regionális Tudományok Bizottsága IXGJO RTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 8</span> | Független: 6 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 7 | Scopus jelölt:&nbsp;2 | WoS/Scopus jelölt:&nbsp;7 | DOI jelölt:&nbsp;8 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33091182&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33091182</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (Artificial Intelligence National Laboratory Programme) Támogató: NKFIH </div> <div class="lastModified">Utolsó módosítás: 2026.02.23. 14:15 Andódy Katalin (BME admin4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Measurement and Information Systems, Budapest University of Technology and EconomicsBudapest H-1111, Hungary Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States Export Date: 22 September 2022</pre> </div></div>