https://m2.mtmt.hu/ eng 2026-10-24 04:19 JournalArticle 33090782 VALIDATED true 0 false 2026-10-22T18:14:10.230+0000 2025-11-06T10:28:32.506+0000 2022-09-13T08:33:32.822+0000 true 10065463 Turek Márta /api/admin/10065463 Admin Márta Turek (KOKI admin 4) true 2026-05-19T11:37:55.631+0000 2026-05-19T11:37:55.631+0000 2023-10-17T13:53:44.626+0000 true 10083379 Belházyné Szombathelyi Ágnes /api/admin/10083379 Admin Ágnes Belházyné Szombathelyi (SZTE admin5) true Admin 10073918 /api/admin/10073918 Marcell Kovács (MTMT Közp., admin) Kovács Marcell true true 2025-10-30T07:42:22.848+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Göcz, Balázs true true /api/journal/10017752 REVIEWED FRONTIERS IN ENDOCRINOLOGY 1664-2392 1664-2392 true false 10017752 false 10017752 true 1664-2392 1664-2392 Journal FOREIGN 13 960769 960769 13 2022 Kisspeptin neurons residing in the rostral periventricular area of the third ventricle (KP RP3V ) and the arcuate nucleus (KP ARC ) mediate positive and negative estrogen feedback, respectively. Here, we aim to compare transcriptional responses of KP RP3V and KP ARC neurons to estrogen. Transgenic mice were ovariectomized and supplemented with either 17β-estradiol (E2) or vehicle. Fluorescently tagged KP RP3V neurons collected by laser-capture microdissection were subjected to RNA-seq. Bioinformatics identified 222 E2-dependent genes. Four genes encoding neuropeptide precursors ( Nmb, Kiss1, Nts, Penk ) were robustly, and Cartpt was subsignificantly upregulated, suggesting putative contribution of multiple neuropeptides to estrogen feedback mechanisms. Using overrepresentation analysis, the most affected KEGG pathways were neuroactive ligand-receptor interaction and dopaminergic synapse. Next, we re-analyzed our previously obtained KP ARC neuron RNA-seq data from the same animals using identical bioinformatic criteria. The identified 1583 E2-induced changes included suppression of many neuropeptide precursors, granins, protein processing enzymes, and other genes related to the secretory pathway. In addition to distinct regulatory responses, KP RP3V and KP ARC neurons exhibited sixty-two common changes in genes encoding three hormone receptors ( Ghsr, Pgr, Npr2 ), GAD-65 ( Gad2 ), calmodulin and its regulator ( Calm1, Pcp4 ), among others. Thirty-four oppositely regulated genes ( Kiss1, Vgf, Chrna7, Tmem35a ) were also identified. The strikingly different transcriptional responses in the two neuron populations prompted us to explore the transcriptional mechanism further. We identified ten E2-dependent transcription factors in KP RP3V and seventy in KP ARC neurons. While none of the ten transcription factors interacted with estrogen receptor-α, eight of the seventy did. We propose that an intricate, multi-layered transcriptional mechanism exists in KP ARC neurons and a less complex one in KP RP3V neurons. These results shed new light on the complexity of estrogen-dependent regulatory mechanisms acting in the two functionally distinct kisspeptin neuron populations and implicate additional neuropeptides and mechanisms in estrogen feedback. Funding 2017631 /api/funding/2017631 National Science Foundation of Hungary(K128317) false true Funding 2017632 /api/funding/2017632 National Science Foundation of Hungary(138137) false true Funding 2017633 /api/funding/2017633 Hungarian Brain Research Program(2017-1.2.1-NKP-2017-00002) false true Funding 2021531 /api/funding/2021531 Hungarian Science Foundation(PD134837) false true true 2022 true true true false true false GOLD 2026-10-22 true https://doi.org/10.3389/fendo.2022.960769 26 0 26 22 4 26 26 23 26 26 26 22 22 22 4 0 26 22 26 22 0 4 4 Folyóiratcikk Journal Article 24 24 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 1 1 1 1 2023 0 6 5 6 5 2024 0 8 7 8 7 2025 0 8 6 8 6 2026 0 3 3 3 3 Q1 false false false false 2022-10-05T10:45:55.121+0000 Bioinformatikai központ (ÁTE / ÁJI); Biokémiai és Molekuláris Biológiai Intézet (DE / ÁOK); Doktori Iskola (SE); Reproduktív Neurobiológia Laboratórium (HRN KOKI) 8 61 4 9 0 true 10073918 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 103384456 /api/authorship/103384456 Göcz, Balázs ✉ [Göcz, Balázs Gergő (Reproduktív neuro...), author] Laboratory of Reproductive Neurobiology; School of PhD Studies (SU) 1 0.111 true false true Author 10062868 /api/author/10062868 Balázs Gergő Göcz (Reproduktív neurobiológia) Göcz Balázs Gergő true 10062868 true Göcz Balázs true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 103384457 /api/authorship/103384457 Takács, Szabolcs [Takács, Szabolcs Ferenc (neuroendokrinológia), author] Laboratory of Reproductive Neurobiology 2 0.111 false false false Author 10028898 /api/author/10028898 Szabolcs Ferenc Takács (neuroendokrinológia) Takács Szabolcs Ferenc true 10028898 true Takács Szabolcs true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 103384458 /api/authorship/103384458 Skrapits, Katalin [Skrapits, Katalin (neuroendokrinológ...), author] Laboratory of Reproductive Neurobiology 3 0.111 false false false Author 10020450 /api/author/10020450 Katalin Skrapits (neuroendokrinológia/reproduktív neurobiológia) Skrapits Katalin true 10020450 true Skrapits Katalin true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 103384459 /api/authorship/103384459 Rumpler, Éva [Rumpler, Éva (Biológia), author] Laboratory of Reproductive Neurobiology 4 0.111 false false false Author 10060241 /api/author/10060241 Éva Rumpler (Biológia) Rumpler Éva true 10060241 true Rumpler Éva true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 103384460 /api/authorship/103384460 Solymosi, Norbert [Solymosi, Norbert (bioinformatika, e...), author] Bioinformatikai központ (UVMB / IASDP) 5 0.111 false false false Author 10017846 /api/author/10017846 Norbert Solymosi (bioinformatika, epidemiológia) Solymosi Norbert true 10017846 true Solymosi Norbert true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 103384461 /api/authorship/103384461 Póliska, Szilárd [Póliska, Szilárd (Elméleti orvostud...), author] Department of Biochemistry and Molecular Biology (UD) 6 0.111 false false false Author 10028436 /api/author/10028436 Szilárd Póliska (Elméleti orvostudományok) Póliska Szilárd true 10028436 true Póliska Szilárd true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 103384462 /api/authorship/103384462 Colledge, William H. 7 0.11111111 false false false Colledge William H. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 103386763 /api/authorship/103386763 Hrabovszky, Erik ✉ [Hrabovszky, Erik (Reproduktív endok...), author] Laboratory of Reproductive Neurobiology 8 0.0 false false true Author 10011472 /api/author/10011472 Erik Hrabovszky (Reproduktív endokrinológia) Hrabovszky Erik true 10011472 true Hrabovszky Erik true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 103384464 /api/authorship/103384464 Sárvári, Miklós ✉ [Sárvári, Miklós (Endokrin neurobio...), author] Laboratory of Reproductive Neurobiology 9 0.111 false true true Author 10014210 /api/author/10014210 Miklós Sárvári (Endokrin neurobiológia) Sárvári Miklós true 10014210 true Sárvári Miklós true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 21673925 /api/publicationidentifier/21673925 DOI: 10.3389/fendo.2022.960769 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3389/fendo.2022.960769 https://doi.org/10.3389/fendo.2022.960769 false true PublicationIdentifier 21674128 /api/publicationidentifier/21674128 REAL: 148483 SwordSource 36 /api/publicationsource/36 REAL PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GREEN true IDENTICAL 148483 https://real.mtak.hu/148483 false true PublicationIdentifier 22415476 /api/publicationidentifier/22415476 WoS: 000890716100001 PlainSource 1 /api/publicationsource/1 WoS 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(2022) FRONTIERS IN ENDOCRINOLOGY 1664-2392 1664-2392 13<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10062868"><a href="/gui2/?type=authors&mode=browse&sel=10062868" target="_blank">Göcz Balázs ✉ (<span class="authorship-author-name">Göcz Balázs Gergő</span> <span class="authorAux-mtmt"> Reproduktív neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Reproductive Neurobiology; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028898"><a href="/gui2/?type=authors&mode=browse&sel=10028898" target="_blank">Takács Szabolcs (<span class="authorship-author-name">Takács Szabolcs Ferenc</span> <span class="authorAux-mtmt"> neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Reproductive Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020450"><a href="/gui2/?type=authors&mode=browse&sel=10020450" target="_blank">Skrapits Katalin (<span class="authorship-author-name">Skrapits Katalin</span> <span class="authorAux-mtmt"> neuroendokrinológia/reproduktív neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Reproductive Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060241"><a href="/gui2/?type=authors&mode=browse&sel=10060241" target="_blank">Rumpler Éva (<span class="authorship-author-name">Rumpler Éva</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Reproductive Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017846"><a href="/gui2/?type=authors&mode=browse&sel=10017846" target="_blank">Solymosi Norbert (<span class="authorship-author-name">Solymosi Norbert</span> <span class="authorAux-mtmt"> bioinformatika, epidemiológia</span>) </a> </span> <span class="author-affil"><span title="University of Veterinary Medicine Budapest">UVMB</span>/<span title="Élelmiszerlánc-biztonsági és Járványvédelmi Intézet">ÉBJI</span>/Bioinformatikai központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028436"><a href="/gui2/?type=authors&mode=browse&sel=10028436" target="_blank">Póliska Szilárd (<span class="authorship-author-name">Póliska Szilárd</span> <span class="authorAux-mtmt"> Elméleti orvostudományok</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Biochemistry and Molecular Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Colledge William H. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011472"><a href="/gui2/?type=authors&mode=browse&sel=10011472" target="_blank">Hrabovszky Erik ✉ (<span class="authorship-author-name">Hrabovszky Erik</span> <span class="authorAux-mtmt"> Reproduktív endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Reproductive Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014210"><a href="/gui2/?type=authors&mode=browse&sel=10014210" target="_blank">Sárvári Miklós ✉ (<span class="authorship-author-name">Sárvári Miklós</span> <span class="authorAux-mtmt"> Endokrin neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Reproductive Neurobiology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33090782" target="_blank">Estrogen differentially regulates transcriptional landscapes of preoptic and arcuate kisspeptin neuron populations</a></div> <div> <span class="journal-title">FRONTIERS IN ENDOCRINOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-2392">1664-2392</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-2392">1664-2392</a>)</span>: <span class="journal-volume">13</span> <span class="page"> Paper 960769. 13 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fendo.2022.960769" target="_blank" href="https://doi.org/10.3389/fendo.2022.960769"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="148483" target="_blank" href="https://real.mtak.hu/148483"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000890716100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000890716100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85138001832" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85138001832"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36093104" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36093104&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 26</span> | Independent citation: 22 | Self citation: 4 | Unknown citation: 0 | Number of citations in WoS: 23 | Number of citations in Scopus:&nbsp;26 | WoS/Scopus assigned:&nbsp;26 | Number of citations with DOI:&nbsp;26 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33090782&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33090782</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> National Science Foundation of Hungary(K128317), National Science Foundation of Hungary(138137), Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002), Hungarian Science Foundation(PD134837) </div> <div class="lastModified">Last Modified: 2025.11.06. 11:28 Marcell Kovács (MTMT Közp., admin) </div> <div class="lockedBy">Centrally managed 2025.10.30. 08:42 Marcell Kovács (MTMT Közp., admin) </div> </div></div>