https://m2.mtmt.hu/ hun 2026-09-23 12:36 JournalArticle 33086714 VALIDATED true 0 false 2026-08-29T17:26:09.509+0000 2026-07-10T06:22:45.171+0000 2022-09-09T09:08:59.692+0000 true 10079111 Gergely Tamás /api/admin/10079111 Admin Gergely Tamás (SE_AOK_Farmakologia_Admin5_GT, admin) true 2026-08-29T17:24:58.713+0000 2023-02-28T16:24:20.047+0000 true 10003134 Wolf György /api/admin/10003134 Admin Wolf György (MTMT Központi admin) true 10003134 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Varga, Bence Tamás true true /api/journal/10066103 REVIEWED PHYSIOLOGY INTERNATIONAL 2498-602X 2677-0164 true true 10066103 false 10066103 true 2498-602X 2677-0164 Journal FOREIGN 109 3 405 418 405 8 2022 Our aim was to establish a pharmacologically induced neurovascular uncoupling (NVU) method in rats as a model of human cognitive decline. Pharmacologically induced NVU with subsequent neurological and cognitive defects was described in mice, but not in rats so far. We used 32 male Hannover Wistar rats. NVU was induced by intraperitoneal administration of a pharmacological “cocktail” consisting of N-(methylsulfonyl)-2-(2-propynyloxy)-benzenehexanamide (MSPPOH, a specific inhibitor of epoxyeicosatrienoic acid-producing epoxidases, 5 mg kg−1), L-NG-nitroarginine methyl ester (L-NAME, a nitric oxide synthase inhibitor, 10 mg kg−1) and indomethacin (a nonselective inhibitor of cyclooxygenases, 1 mg kg−1) and injected twice daily for 8 consecutive days. Cognitive performance was tested in the Morris water-maze and fear-conditioning assays. We also monitored blood pressure. In a terminal operation a laser Doppler probe was used to detect changes in blood-flow (CBF) in the barrel cortex while the contralateral whisker pad was stimulated. Brain and small intestine tissue samples were collected post mortem and examined for prostaglandin E2 (PGE2) level. Animals treated with the “cocktail” showed no impairment in their performance in any of the cognitive tasks. They had higher blood pressure and showed cca. 50% decrease in CBF. Intestinal bleeding and ulcers were found in some animals with significantly decreased levels of PGE2 in the brain and small intestine. Although we could evoke NVU by the applied mixture of pharmacons, it also induced adverse side effects such as hypertension and intestinal malformations while the treatment did not cause cognitive impairment. 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false 2022-12-08T10:13:59.328+0000 Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I) 7 19 1 7 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 103363429 /api/authorship/103363429 Varga, Bence Tamás [Varga, Bence Tamás (Farmakológia), szerző] Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I) 1 0.14285715 true false false Author 10075565 /api/author/10075565 Varga Bence Tamás (Farmakológia) Varga Bence Tamás true true Varga Bence Tamás true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 103363430 /api/authorship/103363430 Gáspár, Attila [Gáspár, Attila (Farmakológia), szerző] Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I) 2 0.14285715 false false false Author 10069238 /api/author/10069238 Gáspár Attila (Farmakológia) Gáspár Attila true true Gáspár Attila true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 103363431 /api/authorship/103363431 Ernyey, Aliz Judit [Ernyey, Alíz Judit (Farmakológia), szerző] Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I) 3 0.14285715 false false false Author 10052997 /api/author/10052997 Ernyey Alíz Judit (Farmakológia) Ernyey Alíz Judit true 10052997 true Ernyey Aliz Judit true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 103363432 /api/authorship/103363432 Hutka, Barbara [Hutka, Barbara (Farmakológia), szerző] Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I) 4 0.14285715 false false false Author 10069237 /api/author/10069237 Hutka Barbara (Farmakológia) Hutka Barbara true true Hutka Barbara true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 103363433 /api/authorship/103363433 Tajti, Brigitta Tekla [Tajti, Brigitta Tekla (Farmakológia), szerző] Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I) 5 0.14285715 false false false Author 10069240 /api/author/10069240 Tajti Brigitta Tekla (Farmakológia) Tajti Brigitta Tekla true true Tajti Brigitta Tekla true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 103363434 /api/authorship/103363434 Zádori, Zoltán Sándor [Zádori, Zoltán Sándor (Farmakológia, gas...), szerző] Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I) 6 0.14285715 false false false Author 10017488 /api/author/10017488 Zádori Zoltán Sándor (Farmakológia, gasztrointesztinális farmakológia) Zádori Zoltán Sándor true 10017488 true Zádori Zoltán Sándor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 103363435 /api/authorship/103363435 Gyertyán, István ✉ [Gyertyán, István (Viselkedésfarmako...), szerző] Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I) 7 0.143 false true true Author 10009109 /api/author/10009109 Gyertyán István (Viselkedésfarmakológia) Gyertyán István true 10009109 true Gyertyán 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(2022) PHYSIOLOGY INTERNATIONAL 2498-602X 2677-0164 109 3 405-418<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10075565"><a href="/gui2/?type=authors&mode=browse&sel=10075565" target="_blank">Varga Bence Tamás (<span class="authorship-author-name">Varga Bence Tamás</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10069238"><a href="/gui2/?type=authors&mode=browse&sel=10069238" target="_blank">Gáspár Attila (<span class="authorship-author-name">Gáspár Attila</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052997"><a href="/gui2/?type=authors&mode=browse&sel=10052997" target="_blank">Ernyey Aliz Judit (<span class="authorship-author-name">Ernyey Alíz Judit</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10069237"><a href="/gui2/?type=authors&mode=browse&sel=10069237" target="_blank">Hutka Barbara (<span class="authorship-author-name">Hutka Barbara</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10069240"><a href="/gui2/?type=authors&mode=browse&sel=10069240" target="_blank">Tajti Brigitta Tekla (<span class="authorship-author-name">Tajti Brigitta Tekla</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017488"><a href="/gui2/?type=authors&mode=browse&sel=10017488" target="_blank">Zádori Zoltán Sándor (<span class="authorship-author-name">Zádori Zoltán Sándor</span> <span class="authorAux-mtmt"> Farmakológia, gasztrointesztinális farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009109"><a href="/gui2/?type=authors&mode=browse&sel=10009109" target="_blank">Gyertyán István ✉ (<span class="authorship-author-name">Gyertyán István</span> <span class="authorAux-mtmt"> Viselkedésfarmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33086714" target="_blank">Introduction of a pharmacological neurovascular uncoupling model in rats based on results of mice</a></div> <div> <span class="journal-title">PHYSIOLOGY INTERNATIONAL</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2498-602X">2498-602X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2677-0164">2677-0164</a>)</span>: <span class="journal-volume">109</span> <span class="journal-issue">3</span> <span class="page"> pp 405-418 </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1556/2060.2022.00226" target="_blank" href="https://doi.org/10.1556/2060.2022.00226"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="152991" target="_blank" href="https://real.mtak.hu/152991"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000892122000008" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000892122000008"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105017831665" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105017831665"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36057105" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36057105&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physiology (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 0 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33086714&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 13 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33086714</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2026.07.10. 08:22 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> </div></div>