https://m2.mtmt.hu/ hun 2026-09-22 12:43 JournalArticle 33081865 VALIDATED true 0 false 2026-07-09T12:35:43.980+0000 2026-03-23T21:13:44.185+0000 2022-09-06T12:09:20.266+0000 true 10078148 Havas Petra /api/admin/10078148 Admin true 2026-03-25T17:15:28.240+0000 2026-03-25T17:15:28.240+0000 2024-02-12T08:41:09.001+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 Admin 10065569 /api/admin/10065569 Pécsi Éva true true 2026-04-14T13:01:34.757+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Szabó, Borbála Aspirin mediates its antitumoral effect through inhibiting PTTG1 in pituitary adenoma true true /api/journal/10030700 REVIEWED true false 10030700 false 10030700 true 0021-972X 1945-7197 Journal FOREIGN 107 11 3066 3079 3066 14 2022 DNA demethylation and inhibitory effect of Aspirin on pituitary cell proliferation have been demonstrated.was to clarify the molecular mechanisms behind the Aspirin-related effects in pituitary cells.DNA methylome and whole transcriptome profile were investigated in RC4-B/C and GH3 pituitary cell lines upon Aspirin treatment. Effects of Aspirin and demethylation agent, decitabine, were further tested in vitro. PTTG1 expression in 41 human PitNET samples and whole genome gene and protein expression data of 76 PitNET and 34 control samples (available in Gene Expression Omnibus) were evaluated.Aspirin induced global DNA demethylation and consequential transcriptome changes. Overexpression of Tet enzymes and their cofactor Uhrf2 were identified behind the increase of 5-hydroxymethylcytosine (5hmC). Besides cell cycle, proliferation and migration that were validated by functional experiments, Aspirin increased Tp53 activity through p53 acetylation and decreased E2f1 activity. Among the p53 controlled genes, Pttg1 and its interacting partners were downregulated upon Aspirin treatment by inhibiting Pttg1 promoter activity. 5hmC positively correlated with Tet1-3, Tp53 expression, and negatively correlated with Pttg1 expression that was reinforced by the effect of decitabine. Additionally, high overlap (20.15%) was found between Aspirin regulated genes and dysregulated genes in PitNET tissue samples.A novel regulatory network has been revealed, where Aspirin regulated global demethylation, Tp53 activity and Pttg1 expression along with decreased cell proliferation and migration. 5hmC, a novel tissue biomarker in PitNET, indicated Aspirin antitumoral effect in vitro too. Our findings suggest the potential beneficial effect of Aspirin in PitNET. Funding 2017718 /api/funding/2017718 false true Funding 2017719 /api/funding/2017719 false true Funding 2017720 /api/funding/2017720 false true true INTERNATIONAL 2022 true true true false true false NONE 2026-07-09 false 12 0 11 8 4 11 12 10 11 11 11 8 8 8 4 0 12 8 11 8 0 8 8 Folyóiratcikk Journal Article 24 11 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 1 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 4 2 4 2 2024 0 2 2 2 2 2025 0 3 2 3 2 2026 0 3 2 3 2 D1 false 10020420,10076057 false false false 2022-10-09T13:22:28.361+0000 Belgyógyászati és Onkológiai Klinika (SE / AOK / K); Laboratóriumi Medicina Intézet (SE / AOK / I); MTA-SE Lendület Örökletes Endokrin Daganatok Ku... (SE / AOK / K / IISZBK); MTA-SE Örökletes Daganatok Kutatócsoport (SE / AOK / I / LABMEDINT); Országos Klinikai Idegtudományi Intézet; Országos Onkológiai Intézet; Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I) 13 60 7 13 0 true 10065569 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 103336007 /api/authorship/103336007 1 0.077 true false false Author 10065387 /api/author/10065387 Szabó Borbála true true Szabó Borbála true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103336008 /api/authorship/103336008 2 0.077 false false false Author 10052152 /api/author/10052152 Németh Kinga true 10052152 true Németh Kinga true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103336009 /api/authorship/103336009 3 0.077 false false false Author 10058121 /api/author/10058121 Mészáros Katalin true 10058121 true Mészáros Katalin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103336010 /api/authorship/103336010 4 0.077 false false false Author 10071844 /api/author/10071844 Krokker Lilla true true Krokker Lilla true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103336011 /api/authorship/103336011 5 0.077 false false false Author 10025130 /api/author/10025130 Likó István true 10025130 true Likó István true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103336012 /api/authorship/103336012 6 0.077 false false false Author 10063558 /api/author/10063558 Saskői Éva true 10063558 true Saskői Éva true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103336013 /api/authorship/103336013 7 0.07692308 false false false Author 10076057 /api/author/10076057 Németh Krisztina true true Németh Krisztina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103336014 /api/authorship/103336014 8 0.07692308 false false false Author 10014589 /api/author/10014589 Szabó Pál Tamás true 10014589 true Szabó Pál Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103336015 /api/authorship/103336015 9 0.077 false false false Author 10015676 /api/author/10015676 Szücs Nikolette true 10015676 true Szücs Nikolette true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103336016 /api/authorship/103336016 10 0.077 false false false Author 10003340 /api/author/10003340 Czirják Sándor true 10003340 true Czirják Sándor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103336017 /api/authorship/103336017 11 0.077 false false false Author 10040820 /api/author/10040820 Szalóki Gábor true 10040820 true Szalóki Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103336018 /api/authorship/103336018 12 0.077 false false false Author 10001006 /api/author/10001006 Patócs Attila Balázs true 10001006 true Patócs Attila true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103336019 /api/authorship/103336019 13 0.077 false true true Author 10020420 /api/author/10020420 Butz Henriett true 10020420 true Butz Henriett true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 21652191 /api/publicationidentifier/21652191 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1210/clinem/dgac496 https://doi.org/10.1210/clinem/dgac496 false true PublicationIdentifier 21779425 /api/publicationidentifier/21779425 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000860402300001 https://www.webofscience.com/wos/woscc/full-record/000860402300001 true true PublicationIdentifier 24215552 /api/publicationidentifier/24215552 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85149738969 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85149738969 false true PublicationIdentifier 21652190 /api/publicationidentifier/21652190 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36059148 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36059148&dopt=Abstract false true Classification 12284 /api/classification/12284 true true Classification 12215 /api/classification/12215 true true Classification 12306 /api/classification/12306 true true Keyword 1563 /api/keyword/1563 true 1563 true Keyword 2922 /api/keyword/2922 true 2922 true Keyword 1004566 /api/keyword/1004566 true 1004566 true Keyword 1035772 /api/keyword/1035772 true 1035772 true Keyword 1069456 /api/keyword/1069456 true 1069456 true Keyword 1156149 /api/keyword/1156149 true 1156149 true Keyword 1700356 /api/keyword/1700356 true true Keyword 1745978 /api/keyword/1745978 true true SjrRating 11311652 /api/sjrrating/11311652 6 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2704 /api/classificationexternal/2704 true 2704 true D1 DIRECT true true /api/publication/33081865 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10065387"><a href="/gui2/?type=authors&mode=browse&sel=10065387" target="_blank">Szabó Borbála (<span class="authorship-author-name">Szabó Borbála</span> <span class="authorAux-mtmt"> Endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Laboratóriumi Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Laboratóriumi Medicina Intézet">LABMEDINT</span>/MTA-SE Örökletes Daganatok Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052152"><a href="/gui2/?type=authors&mode=browse&sel=10052152" target="_blank">Németh Kinga (<span class="authorship-author-name">Németh Kinga</span> <span class="authorAux-mtmt"> orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="II. Sz. Belgyógyászati Klinika">IISZBK</span>/MTA-SE Lendület Örökletes Endokrin Daganatok Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10058121"><a href="/gui2/?type=authors&mode=browse&sel=10058121" target="_blank">Mészáros Katalin (<span class="authorship-author-name">Mészáros Katalin</span> <span class="authorAux-mtmt"> orvosi laboratóriumi diagnosztika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Laboratóriumi Medicina Intézet">LABMEDINT</span>/MTA-SE Örökletes Daganatok Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071844"><a href="/gui2/?type=authors&mode=browse&sel=10071844" target="_blank">Krokker Lilla (<span class="authorship-author-name">Krokker Lilla</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Laboratóriumi Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="II. Sz. Belgyógyászati Klinika">IISZBK</span>/MTA-SE Lendület Örökletes Endokrin Daganatok Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025130"><a href="/gui2/?type=authors&mode=browse&sel=10025130" target="_blank">Likó István (<span class="authorship-author-name">Likó István</span> <span class="authorAux-mtmt"> Bioinformatika-Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Laboratóriumi Medicina Intézet">LABMEDINT</span>/MTA-SE Örökletes Daganatok Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10063558"><a href="/gui2/?type=authors&mode=browse&sel=10063558" target="_blank">Saskői Éva (<span class="authorship-author-name">Saskői Éva</span> <span class="authorAux-mtmt"> </span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10076057"><a href="/gui2/?type=authors&mode=browse&sel=10076057" target="_blank">Németh Krisztina (<span class="authorship-author-name">Németh Krisztina</span> <span class="authorAux-mtmt"> Tömegspektrometria</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014589"><a href="/gui2/?type=authors&mode=browse&sel=10014589" target="_blank">Szabó Pál Tamás (<span class="authorship-author-name">Szabó Pál Tamás</span> <span class="authorAux-mtmt"> Tömegspektrometria</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015676"><a href="/gui2/?type=authors&mode=browse&sel=10015676" target="_blank">Szücs Nikolette (<span class="authorship-author-name">Szücs Nikolette</span> <span class="authorAux-mtmt"> Belgyógyászati, endokrinologia, molekuláris éle...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003340"><a href="/gui2/?type=authors&mode=browse&sel=10003340" target="_blank">Czirják Sándor (<span class="authorship-author-name">Czirják Sándor</span> <span class="authorAux-mtmt"> Idegsebészet</span>) </a> </span> <span class="author-affil">Országos Klinikai Idegtudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040820"><a href="/gui2/?type=authors&mode=browse&sel=10040820" target="_blank">Szalóki Gábor (<span class="authorship-author-name">Szalóki Gábor</span> <span class="authorAux-mtmt"> elméleti orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001006"><a href="/gui2/?type=authors&mode=browse&sel=10001006" target="_blank">Patócs Attila (<span class="authorship-author-name">Patócs Attila Balázs</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Laboratóriumi Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Laboratóriumi Medicina Intézet">LABMEDINT</span>/MTA-SE Örökletes Daganatok Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020420"><a href="/gui2/?type=authors&mode=browse&sel=10020420" target="_blank">Butz Henriett ✉ (<span class="authorship-author-name">Butz Henriett</span> <span class="authorAux-mtmt"> orvostudomány</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Laboratóriumi Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Laboratóriumi Medicina Intézet">LABMEDINT</span>/MTA-SE Örökletes Daganatok Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33081865" target="_blank">Aspirin mediates its antitumoral effect through inhibiting PTTG1 in pituitary adenoma</a></div> <div> <span class="journal-title">JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0021-972X">0021-972X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1945-7197">1945-7197</a>)</span>: <span class="journal-volume">107</span> <span class="journal-issue">11</span> <span class="page"> pp 3066-3079 </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1210/clinem/dgac496" target="_blank" href="https://doi.org/10.1210/clinem/dgac496"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000860402300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000860402300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85149738969" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85149738969"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36059148" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36059148&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Clinical Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 12</span> | Független: 8 | Függő: 4 | Nem jelölt: 0 | WoS jelölt: 10 | Scopus jelölt:&nbsp;11 | WoS/Scopus jelölt:&nbsp;11 | DOI jelölt:&nbsp;12 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33081865&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33081865</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> National Laboratories Excellence program (under the National Tumor Biology Laboratory Project(NLP-17), Hungarian Thematic Excellence Program((TKP2021-EGA-44)), (NKFI FK 135065) Támogató: OTKA </div> <div class="lastModified">Utolsó módosítás: 2026.03.23. 22:13 Pécsi Éva (MTMT Közp 2,3, admin) </div> <div class="lockedBy">Központi kezelésű 2026.04.14. 15:01 Pécsi Éva (MTMT Közp 2,3, admin) </div> </div></div>