Relationship between Cardiac Troponin and Thrombo-Inflammatory Molecules in Prediction of Outcome after Acute Ischemic Stroke.

Csecsei, P [Csécsei, Péter (Neurológia), szerző] Neurológiai Klinika (PTE / ÁOK); Pusch, G [Pusch, Gabriella (Neurológia), szerző] Neurológiai Klinika (PTE / ÁOK); Ezer, E [Ezer, Erzsébet (Intenzív-anesztez...), szerző] Aneszteziológiai és Intenzív Terápiás Intézet (PTE / ÁOK); Berki, T [Berki, Tímea (Immunológia), szerző] Immunológiai és Biotechnológiai Intézet (PTE / ÁOK); Szapary, L [Szapáry, László (Agyérbetegségek, ...), szerző] Neurológiai Klinika (PTE / ÁOK); Illes, Z [Illés, Zsolt László (Neurológia, neuro...), szerző]; Molnar, T [Molnár, Tihamér (Aneszteziológia), szerző] Aneszteziológiai és Intenzív Terápiás Intézet (PTE / ÁOK)

Angol nyelvű Tudományos Szakcikk (Folyóiratcikk)
  • SJR Scopus - Rehabilitation: Q1
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Szakterületek:
    BACKGROUND: In patients with acute ischemic stroke (AIS) without cardiovascular complications, we investigated the association of serum concentration of cardiac troponin (high-sensitivity cardiac troponin T [hs-cTnT]) with thrombo-inflammatory markers. METHODS: Thirty-five patients with first-ever AIS were prospectively examined. Serum hs-cTnT was measured 6 and 24 hours after stroke, whereas S100B, high-sensitivity C-reactive protein (hsCRP), soluble CD40 ligand, tissue plasminogen activator (tPA), monocyte chemoattractant protein-1 (MCP-1), and P-selectin were measured 6 and 72 hours after stroke. Severity of stroke was assessed by the National Institutes of Health Stroke Scale (NIHSS) on admission, 24 hours later, and at discharge. RESULTS: Concentration of MCP-1 at 6 hours was higher in the serum of patients with worsened NIHSS by 24 hours (P = .009). Concentration of hs-cTnT at both 6 and 24 hours was higher, if NIHSS worsened by discharge (P = .026 and P = .001). A cutoff value for hs-cTnT measured at T24 greater than or equal to 9.4 predicted worsened NIHSS on discharge with a sensitivity of 81% and a specificity of 74% (area: .808, P = .002). Concentration of hs-cTnT at both 6 and 24 hours was also higher in nonsurvivors compared with survivors (P = .03, respectively), and correlated with (1) tPA levels at 6 hours (P = .001 and P = .002, respectively); (2) MCP-1 concentration at 6 hours (P = .01 and P = .015, respectively); and increased hsCRP levels at 72 hours (P = .01, respectively). Concentration of hs-cTnT at 24 hours was an independent predictor of worsened NIHSS at discharge (odds ratio: 1.58, 95% confidence interval: 1.063-2.370, P = .024). CONCLUSIONS: Elevated concentration of hs-cTnT measured 24 hours after AIS is an independent predictor of progressing neurologic deficit in patients without apparent myocardial damage, and also correlates with acute elevation of tPA and MCP-1.
    Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
    2021-09-21 14:22