Growth Factor Release within Liquid and Solid PRF

https://m2.mtmt.hu/ hun 2026-09-23 05:46 JournalArticle 33075279 VALIDATED true 0 false 2026-07-13T20:21:11.439+0000 2022-09-27T06:19:34.037+0000 2022-08-31T19:16:58.751+0000 true 10018804 Szalóky-Siki Ágnes /api/admin/10018804 Admin Szalóky-Siki Ágnes (SE_FOK_Admin5_SIKIÁ, admin) true 10018804 2022-10-20T11:10:09.911+0000 2022-10-20T11:10:09.911+0000 2022-09-19T11:43:12.558+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Zwittnig, Katharina Growth Factor Release within Liquid and Solid PRF true true /api/journal/10017543 REVIEWED JOURNAL OF CLINICAL MEDICINE 2077-0383 true false 10017543 false 10017543 true 2077-0383 Journal FOREIGN 11 17 5070 5070 10 2022 Aim: The purpose of this study was to obtain data concerning growth factor release within liquid and solid platelet-rich fibrin (PRF) matrices and to estimate the amount of potential interindividual variations as a basis for further preclinical and clinical trials. Therefore, we aimed to determine possible differences in the release of growth factors between liquid and solid PRF. Materials and Methods: Blood samples obtained from four subjects were processed to both liquid and solid PRF matrices using a standard centrifugation protocol. Five growth factors (vascular endothelial growth factor, VEGF; epidermal growth factor, EGF; platelet-derived growth factor-BB, PDGF-BB; transforming growth factor-β1, TGF-β1; and matrix metallopeptidase 9, MMP-9) have been evaluated at six time points by ELISA over a total observation period of 10 days (1 h, 7 h, 1 d, 2 d, 7 d, and 10 d). Results: Growth factor release could be measured in all samples at each time point. Comparing liquid and solid PRF matrices, no significant differences were detected (p > 0.05). The mean release of VEGF, TGFβ-1, PDGF-BB, and MMP-9 raised to a peak at time point five (day 7) in both liquid and solid PRF matrices. VEGF release was lower in liquid PRF than in solid PRF, whereas those of PDGF-BB and MMP-9 were higher in liquid PRF than in solid PRF at all time points. EGF had its peak release already at time point two after 7 h in liquid and solid matrices (hour 7 EGF solid: mean = 180 pg/mL, SD = 81; EGF liquid: mean = 218 pg/mL, SD = 64), declined rapidly until day 2, and had a second slight peak on day 7 in both groups (day 7 EGF solid: mean = 182 pg/mL, SD = 189; EGF liquid: mean = 81 pg/mL, SD = 70). Conclusions: This study detected growth factor release within liquid and solid PRF matrices with little variations. Further preclinical trials are needed to precisely analyze the growth factor release in larger samples and to better understand their effects on wound healing in different clinical indications. true 2022 true true true false true false GOLD 2026-07-13 true https://doi.org/10.3390/jcm11175070 42 0 42 41 0 42 42 37 41 42 42 41 41 41 1 0 42 41 42 41 0 0 0 Folyóiratcikk Journal Article 24 42 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 4 4 4 4 2024 0 14 13 14 13 2025 0 16 16 16 16 2026 0 8 8 8 8 Q1 false false false false 2022-09-18T11:43:12.337+0000 Fogpótlástani Klinika (SE / FOK) 1 8 1 10 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 103304883 /api/authorship/103304883 Zwittnig, Katharina 1 0.1 true false false Zwittnig Katharina true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 103304884 /api/authorship/103304884 Kirnbauer, Barbara* 2 0.1 true false false Kirnbauer Barbara true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 103304885 /api/authorship/103304885 Jakse, Norbert 3 0.1 false false false Jakse Norbert true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 103304886 /api/authorship/103304886 Schlenke, Peter 4 0.1 false false false Schlenke Peter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 103304887 /api/authorship/103304887 Mischak, Irene 5 0.1 false false false Mischak Irene true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 103304888 /api/authorship/103304888 Ghanaati, Shahram 6 0.1 false false false Ghanaati Shahram true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 103304889 /api/authorship/103304889 Al-Maawi, Sarah 7 0.1 false false false Al-Maawi Sarah true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 103304890 /api/authorship/103304890 Végh, Dániel [Végh, Dániel (Diabétesz és a sz...), szerző] Fogpótlástani Klinika (SE / FOK) 8 0.1 false false false Author 10059531 /api/author/10059531 Végh Dániel (Diabétesz és a szájüregi egészség kapcsolata) Végh Dániel true 10059531 true Végh Dániel true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 103304891 /api/authorship/103304891 Payer, Michael** ✉ 9 0.1 false true true Payer Michael true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 103304892 /api/authorship/103304892 Zrnc, Tomislav A. 10 0.1 false true false Zrnc Tomislav A. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 21637942 /api/publicationidentifier/21637942 DOI: 10.3390/jcm11175070 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/jcm11175070 https://doi.org/10.3390/jcm11175070 false true PublicationIdentifier 21695678 /api/publicationidentifier/21695678 WoS: 000851196300001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 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(2022) JOURNAL OF CLINICAL MEDICINE 2077-0383 11 17<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" >Zwittnig Katharina </span> ;    <span class="author-name" >Kirnbauer Barbara<sup>*</sup> </span> ;    <span class="author-name" >Jakse Norbert </span> ;    <span class="author-name" >Schlenke Peter </span> ;    <span class="author-name" >Mischak Irene </span> ;    <span class="author-name" >Ghanaati Shahram </span> ;    <span class="author-name" >Al-Maawi Sarah </span> ;    <span class="author-name" mtid="10059531"><a href="/gui2/?type=authors&mode=browse&sel=10059531" target="_blank">Végh Dániel (<span class="authorship-author-name">Végh Dániel</span> <span class="authorAux-mtmt"> Diabétesz és a szájüregi egészség kapcsolata</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Fogpótlástani Klinika</span> ;    <span class="author-name" >Payer Michael<sup>**</sup> ✉ </span> ;    <span class="author-name" >Zrnc Tomislav A. </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33075279" target="_blank">Growth Factor Release within Liquid and Solid PRF</a></div> <div> <span class="journal-title">JOURNAL OF CLINICAL MEDICINE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2077-0383">2077-0383</a>)</span>: <span class="journal-volume">11</span> <span class="journal-issue">17</span> <span class="page"> Paper 5070. 10 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/jcm11175070" target="_blank" href="https://doi.org/10.3390/jcm11175070"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000851196300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000851196300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85137763887" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85137763887"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36078998" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36078998&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)   SJR indikátor: Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 42</span> | Független: 41 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 37 | Scopus jelölt: 41 | WoS/Scopus jelölt: 42 | DOI jelölt: 42 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33075279</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2022.09.27. 08:19 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> </div></div>