https://m2.mtmt.hu/ eng 2026-10-23 18:49 JournalArticle 33074730 VALIDATED true 0 false 2026-10-22T17:10:56.597+0000 2026-05-08T10:13:37.689+0000 2022-08-31T13:29:29.349+0000 true 10069305 Kondor Zóra /api/admin/10069305 Admin true 2026-05-14T11:22:09.861+0000 2026-05-14T11:22:09.861+0000 2026-05-08T10:13:37.822+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Vágó, Hajnalka Immunological response and temporal associations in myocarditis after COVID-19 vaccination using cardiac magnetic resonance imaging: an amplified T-cell response at the heart of it? true true /api/journal/10062301 REVIEWED true false 10062301 false 10062301 true 2297-055X 2297-055X Journal FOREIGN 9 961031 961031 14 2022 <sec>IntroductionAlthough myocarditis after anti-SARS-CoV-2 vaccination is increasingly recognized, we have little data regarding the course of the disease and, consequently, the imaging findings, including the tissue-specific features. The purpose of this study is to describe the clinical, immunological, and cardiac magnetic resonance (CMR) features of myocarditis after COVID-19 immunization in the acute phase and during follow-up. We aimed to compare the trajectory of the disease to myocarditis cases unrelated to COVID-19.</sec><sec>MethodsWe assembled a CMR-based registry of potentially COVID-19 vaccination-related myocarditis cases. All patients who experienced new-onset chest pain and troponin elevation after COVID-19 vaccination and imaging confirming the clinical suspicion of acute myocarditis were enrolled in our study. Participants underwent routine laboratory testing and testing of their humoral and cellular immune response to COVID-19 vaccination. Clinical and CMR follow-up was performed after 3–6 months. We included two separate, sex- and age-matched control groups: (1) individuals with myocarditis unrelated to COVID-19 infection or vaccination confirmed by CMR and (2) volunteers with similar immunological exposure to SARS-CoV-2 compared to our group of interest (no difference in the number of doses, types and the time since anti-SARS-CoV-2 vaccination and no difference in anti-nucleocapsid levels).</sec><sec>ResultsWe report 16 CMR-confirmed cases of myocarditis presenting (mean ± SD) 4 ± 2 days after administration of the anti-SARS-CoV-2 vaccine (male patients, 22 ± 7 years), frequently with predisposing factors such as immune-mediated disease and previous myocarditis. We found that 75% received mRNA vaccines, and 25% received vector vaccines. During follow-up, CMR metrics depicting myocardial injury, including oedema and necrosis, decreased or completely disappeared. There was no difference regarding the CMR metrics between myocarditis after immunization and myocarditis unrelated to COVID-19. We found an increased T-cell response among myocarditis patients compared to matched controls (p < 0.01), while there was no difference in the humoral immune response.</sec><sec>ConclusionIn our cohort, myocarditis occurred after both mRNA and vector anti-SARS-CoV-2 vaccination, frequently in individuals with predisposing factors. Upon follow-up, the myocardial injury had healed. Notably, an amplified cellular immune response was found in acute myocarditis cases occurring 4 days after COVID-19 vaccination.</sec> Funding 2018011 /api/funding/2018011 false true Funding 2018012 /api/funding/2018012 false true Funding 2018013 /api/funding/2018013 false true Funding 2018014 /api/funding/2018014 false true true true 2022 true true true false true false GOLD 2026-10-22 true https://doi.org/10.3389/fcvm.2022.961031 6 0 6 5 2 5 6 5 6 6 6 5 5 5 1 0 6 5 6 5 0 1 1 Folyóiratcikk Journal Article 24 6 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference 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/api/publication/33074730 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10013981"><a href="/gui2/?type=authors&mode=browse&sel=10013981" target="_blank">Vágó Hajnalka ✉ (<span class="authorship-author-name">Vágó Hajnalka</span> <span class="authorAux-mtmt"> Kardiológia, MR</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Faculty of Sports Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10067735"><a href="/gui2/?type=authors&mode=browse&sel=10067735" target="_blank">Szabó Liliána<sup>*</sup> (<span class="authorship-author-name">Szabó Liliána</span> <span class="authorAux-mtmt"> kardiovaszkularis kepalkotas</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10086207"><a href="/gui2/?type=authors&mode=browse&sel=10086207" target="_blank">Szabó Zsófia (<span class="authorship-author-name">Szabó Zsófia</span> <span class="authorAux-mtmt"> Immunológiai laboratóriumi diagnosztika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Laboratory Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10089497"><a href="/gui2/?type=authors&mode=browse&sel=10089497" target="_blank">Ulakcsai Zsuzsanna (<span class="authorship-author-name">Ulakcsai Zsuzsanna</span> <span class="authorAux-mtmt"> aneszteziológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Anesthesoiology and Intensiv Therapy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szögi Emese </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Budai Gizella </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10022862"><a href="/gui2/?type=authors&mode=browse&sel=10022862" target="_blank">Tóth Attila (<span class="authorship-author-name">Tóth Attila</span> <span class="authorAux-mtmt"> Radiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10077410"><a href="/gui2/?type=authors&mode=browse&sel=10077410" target="_blank">Juhász Vencel (<span class="authorship-author-name">Juhász Vencel</span> <span class="authorAux-mtmt"> Kardiológia, Sportorvostan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061091"><a href="/gui2/?type=authors&mode=browse&sel=10061091" target="_blank">Dohy Zsófia (<span class="authorship-author-name">Dohy Zsófia</span> <span class="authorAux-mtmt"> orvostudományok, kardiológia, MR</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hoffer Krisztina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013967"><a href="/gui2/?type=authors&mode=browse&sel=10013967" target="_blank">Becker Dávid (<span class="authorship-author-name">Becker Dávid</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kiss Róbert Gábor </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054700"><a href="/gui2/?type=authors&mode=browse&sel=10054700" target="_blank">Nagy György Gergely (<span class="authorship-author-name">Nagy Gergely György</span> <span class="authorAux-mtmt"> orvostudomány, egészségtudomány</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Belgyógyászati Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025749"><a href="/gui2/?type=authors&mode=browse&sel=10025749" target="_blank">Nagy György<sup>**</sup> (<span class="authorship-author-name">Nagy György</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Cardiology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Genetics, Cell- and Immunology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Internal Medicine and Oncology">DIMO</span>/Department of Rheumatology and Clinical Immunology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Merkely Béla (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Faculty of Sports Medicine</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33074730" target="_blank">Immunological response and temporal associations in myocarditis after COVID-19 vaccination using cardiac magnetic resonance imaging: an amplified T-cell response at the heart of it?</a></div> <div> <span class="journal-title">FRONTIERS IN CARDIOVASCULAR MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2297-055X">2297-055X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2297-055X">2297-055X</a>)</span>: <span class="journal-volume">9</span> <span class="page"> Paper 961031. 14 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fcvm.2022.961031" target="_blank" href="https://doi.org/10.3389/fcvm.2022.961031"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000862103500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000862103500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85139037080" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85139037080"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36186968" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36186968&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 6</span> | Independent citation: 5 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 5 | Number of citations in Scopus:&nbsp;6 | WoS/Scopus assigned:&nbsp;6 | Number of citations with DOI:&nbsp;6 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33074730&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33074730</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (Therapeutic Development and Bioimaging thematic programmes of the Semmelweis University), (K135076), (2020-1.1.6-JOVO-2021-00013), Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Funder: EFOP-VEKOP </div> <div class="lastModified">Last Modified: 2026.05.08. 12:13 Tamásné Gere (SE_KK_Admin5_GT, admin) </div> </div></div>