https://m2.mtmt.hu/ eng 2026-04-17 05:16 JournalArticle 33073358 APPROVED IMPORT_WITH_ERROR true Funding Agency and Grant Number: National Scientific Research Program [OTKA K-131479]; Rheuma Tolerance for Cure [H2020 777357]; Ministry of Innovation and Technology of Hungary from the National Research, Development, and Innovation Fund [TKP2021-EGA/TKP2021-NVA/ TKP2021-NKTA] Funding text: This work was supported by grants from the National Scientific Research Program OTKA K-131479, the Rheuma Tolerance for Cure H2020 777357, and with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development, and Innovation Fund, financed under the TKP2021-EGA/TKP2021-NVA/ TKP2021-NKTA funding scheme. 0 false 2026-04-15T12:53:22.766+0000 2026-04-05T08:42:10.078+0000 2022-08-31T09:23:28.306+0000 true 10038287 Császár-Nagy Noémi /api/author/10038287 Author true 10038287 2026-04-05T08:42:09.545+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Majnik, Judit Non-pharmacological treatment in difficult-to-treat rheumatoid arthritis true true /api/journal/10035348 REVIEWED true false 10035348 false 10035348 true 2296-858X Journal FOREIGN 9 991677 991677 9 2022 Although the management of rheumatoid arthritis (RA) has improved remarkably with new pharmacological therapies, there is still a significant part of patients not reaching treatment goals. Difficult-to-treat RA (D2TRA) is a complex entity involving several factors apart from persistent inflammation, thereafter requiring a holistic management approach. As pharmacological treatment options are often limited in D2TRA, the need for non-pharmacological treatments (NPT) is even more pronounced. The mechanism of action of non-pharmacological treatments is not well investigated, NPTs seem to have a complex, holistic effect including the immune, neural and endocrine system, which can have a significant additive benefit together with targeted pharmacotherapies in the treatment of D2TRA. In this review we summarize the current knowledge on different NPT in rheumatoid arthritis, and we propose a NPT plan to follow when managing D2TRA patients. 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target="_blank">Majnik Judit ✉ (<span class="authorship-author-name">Majnik Judit Zsuzsanna</span> <span class="authorAux-mtmt"> Endokrinológia, molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Internal Medicine and Oncology">DIMO</span>/Department of Rheumatology and Clinical Immunology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038287"><a href="/gui2/?type=authors&mode=browse&sel=10038287" target="_blank">Császár-Nagy Noémi (<span class="authorship-author-name">Császár-Nagy Noémi</span> <span class="authorAux-mtmt"> klinikai szakpszichológus</span>) </a> </span> <span class="author-affil"><span title="University of Public Service">UPS</span>/<span title="Államtudományi és Nemzetközi Tanulmányok Kar">ÁNTK</span>/Közszervezési és Infotechnológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Böcskei Georgina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013912"><a href="/gui2/?type=authors&mode=browse&sel=10013912" target="_blank">Bender Tamás (<span class="authorship-author-name">Bender Tamás</span> <span class="authorAux-mtmt"> Balneoterápia, medicina</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025749"><a href="/gui2/?type=authors&mode=browse&sel=10025749" target="_blank">Nagy György (<span class="authorship-author-name">Nagy György</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Genetics, Cell- and Immunology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Internal Medicine and Oncology">DIMO</span>/Department of Rheumatology and Clinical Immunology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33073358" target="_blank">Non-pharmacological treatment in difficult-to-treat rheumatoid arthritis</a></div> <div> <span class="journal-title">FRONTIERS IN MEDICINE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2296-858X">2296-858X</a>)</span>: <span class="journal-volume">9</span> <span class="page"> Paper 991677. 9 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3389/fmed.2022.991677" target="_blank" href="https://doi.org/10.3389/fmed.2022.991677"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="20112" target="_blank" href="https://tudasportal.uni-nke.hu/xmlui/handle/20.500.12944/20112"> Közszolgálati Tudásportál </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000872880100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000872880100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85138241718" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85138241718"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36106320" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36106320&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 39</span> | Independent citation: 36 | Self citation: 3 | Unknown citation: 0 | Number of citations in WoS: 27 | Number of citations in Scopus:&nbsp;28 | WoS/Scopus assigned:&nbsp;31 | Number of citations with DOI:&nbsp;33 (Not published:&nbsp;18) </div> <div class="publication-citation" style="margin-left: 0.5cm; margin-top:0"> <span title="" class="citingPub-count">Citation count: 40</span> | Independent citation: 37 | Self citation: 3 | Unknown citation: 0 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33073358&sort=publishedYear,desc&sort=title"> Number of cited publications: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33073358</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="errorStatus"> Import with error </span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (OTKA K131479) Funder: HSRF, (TKP2021-EGA/TKP2021-NVA/TKP2021-NKTA) </div> <div class="lastModified">Last Modified: 2026.04.05. 10:42 Márta Molnár-Taga (SE 4-es admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: National Scientific Research Program [OTKA K-131479]; Rheuma Tolerance for Cure [H2020 777357]; Ministry of Innovation and Technology of Hungary from the National Research, Development, and Innovation Fund [TKP2021-EGA/TKP2021-NVA/ TKP2021-NKTA] Funding text: This work was supported by grants from the National Scientific Research Program OTKA K-13147...</pre> </div></div>