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realizing the concept of “Setting the City by Water” for Xiong’an New Area. Understanding the process and characteristics of the eco-environmental change in Baiyangdian Lake will provide scientific data for water and environmental management. This study reconstructed the history of diatom compositional and diversity changes based on a 79-cm long sediment record(CPT) (38.83°N, 116.04°E) extracted from the southeast part of the Baiyangdian Lake at a water depth about 3 m, and discussed the mechanisms behind the changes by combining physical and geochemical proxies from the same core, regional meteorological data and indices reflecting human activities. In this study, a total of 40 samples collected from the core at 2-cm intervals were measured for 210Pb and 137Cs activities. According to the 210Pb/137Cs-based age-depth model, the basal sediment at 79-cm depth was deposited around 1938 A.D. The average sedimentary rate throughout the core was estimated ca. 0.984 cm/a. 71 samples from different depths were collected for grain-size analysis and 40 samples were taken at 2-cm intervals for diatom analysis. The results show that the dominate species in the core include Achnanthidium minutissimum, Amphora copulata, Puncticulata praetermissa, Pantocsekiella ocellata and Cyclotella distinguenda. The major diatom compositional shifts occurred around 1955 A.D., 1973 A.D., 1993 A.D. and 2002 A.D. Redundancy analysis(RDA) and variance partitioning analysis(VPA) show that climatic variables and human activities exerted different amounts of influence on diatom compositional and diversity changes, for which annual mean temperature, lake level and P content contributed more compared to other variables. Annual mean temperature has the largest independent explanation for the variations of diatom compositional change, indicating that temperature will probably exert stronger impact on the lake ecosystem if the climate keep warming. Three species diversity indices, including species richness, species evenness and β diversity(βsor), were calculated for the diatom data from the core. Among these indices, species richness and evenness show overall increasing trends while βsor reveals a decreasing trend over the past 80 years. This implies a net diatom species gain in the southeast part of the Baiyangdian Lake during this period, but meanwhile, the diatom community structure became homogenized. Ordinary least square cumulative sum(OLS-CUSUM) failed to detect catastrophe point from diatom composition(PC1) and diatom diversity(species richness, species evenness and βsor), which indicates that human activities and climate change over the recent decades have not yet caused remarkable shift in the lake ecological regime. Therefore, we believed that reducing environmental pressure is expected to maintain the resilience and stability of the aquatic ecosystem in the southeast part of Baiyangdian Lake. For the heavily polluted lake area like the Shaochedian in the north part of the lake, the dominant species in the lake sediments and the trajectory of diatom compositional change are completely different from the present study. Further analyses are required to detect whether ecological regime had shifted or not in such lake area. In view of the great spatial difference of the water environment in Baiyangdian Lake, we suggested that strategies for water environmental protection should be developed according to site-specific conditions. © 2021, Science Press (China). 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