Even during normal pregnancy, significant morphological, functional and hemodynamic
changes take place in the kidneys, resulting in a slightly increased proteinuria.
However, an abnormal increase, especially if accompanied by hypertension or impaired
renal function, requires close maternal and fetal follow-up, as it may predict severe
perinatal complications. Differential diagnosis of proteinuria is diverse, and the
primary consideration in clarifying the etiology is to differentiate between preeclampsia
and other possible primary kidney disease. We list all the diseases on the etiological
palette that may even mimic the symptoms of preeclampsia, making it difficult to make
an accurate diagnosis. In the case of a 31-year-old gravida, we review the differential
diagnosis of progressive proteinuria observed during pregnancy. In addition to the
diagnosis of postpartum preeclampsia, renal malignancy was confirmed. We are also
looking for the answer whether malignant kidney cancer can be blamed for the clinical
presentation that includes hypertension, progressive proteinuria. Orv Hetil. 2022;
163(34): 1362-1368.
