https://m2.mtmt.hu/ hun 2026-10-23 18:49 JournalArticle 33060697 ADMIN_APPROVED true Funding Agency and Grant Number: Hungarian National Research, Development and Innovation Office (OTKA) [124652, 129664]; Austrian Science Fund [FWF I3522, FWF I3977, I4677]; Hungarian National Research, Development and Innovation Office [KH130356, 2020-1.1.6-JoVO, TKP2021-EGA-33]; Bolyai Research Scholarship of the Hungarian Academy of Sciences; New National Excellence Program of the Ministry for Innovation and Technology [UNKP-19-4]; New National Excellence Program of the Ministry for Innovation and Technology of Hungary [UNKP-20-3, UNKP-21-3]; Hungarian Respiratory Society Funding text: The authors thank the patients and the clinical teams involved. We thank Leslie Rozeboom, UCD, for her assistance in creating TMA blocks. ZL acknowledges funding from the Hungarian National Research, Development and Innovation Office (OTKA #124652 and OTKA #129664). BD acknowledges funding from the Austrian Science Fund (FWF I3522, FWF I3977 and I4677) and from the Hungarian National Research, Development and Innovation Office (KH130356; 2020-1.1.6-JoVO and TKP2021-EGA-33). VL is a recipient of the Bolyai Research Scholarship of the Hungarian Academy of Sciences and the UNKP-19-4 New National Excellence Program of the Ministry for Innovation and Technology. ZM was supported by the UNKP-20-3 and UNKP-21-3 New National Excellence Program of the Ministry for Innovation and Technology of Hungary and by the Hungarian Respiratory Society (MPA #2020). 0 false 2026-10-22T16:31:01.242+0000 2024-09-29T23:15:03.566+0000 2022-08-22T13:11:14.802+0000 true 10081340 Pirmann Tamás /api/admin/10081340 Admin true 2026-04-21T15:24:32.880+0000 2024-09-29T23:15:03.935+0000 true 10058227 Áts József /api/admin/10058227 Admin true 10058227 Admin 10073918 /api/admin/10073918 Kovács Marcell true true Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2023-10-04T07:54:51.165+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Dora, David Protein Expression of immune checkpoints STING and MHCII in small cell lung cancer. true true /api/journal/907 REVIEWED true false 907 false 907 true 1432-0851 0340-7004 Journal FOREIGN 72 3 561 578 561 18 2023 SCLC is an aggressive malignancy where immunotherapies show limited efficacy. We aimed to characterize the SCLC microenvironment according to the expression patterns of SCLC subtype markers and novel immune checkpoints to identify therapeutic vulnerabilities.We included SCLC tissue samples from 219 surgically resected, limited-stage patients in this cross-sectional study. We performed immunohistochemistry for STING and MHCII, as well as for the novel subtype markers (ASCL1, NEUROD1, POU2F3, YAP1). Moreover, we assessed CD45 + , CD8 + and CD68 + immune cell infiltration.36% of SCLC tumors showed significant stromal or intraepithelial CD45 + immune cell infiltration. These patients exhibited significantly increased overall survival (OS) (vs. patients with immune-deserted tumors). High CD8 expression was associated with increased median OS. We found STING expression on cancer-associated fibroblasts in the stroma and on T-cells and macrophages in both tumorous and stromal compartments. STING expression positively correlated with immune cell infiltration. Increased STING-positivity in tumor nests was an independent favorable prognosticator for OS. ASCL1 was the most frequently expressed subtype-specific protein. Concomitant expression of three or four subtype-defining markers was seen in 13.8% of the included samples, whereas 24.1% of the cases were classified as quadruple negative tumors. YAP1 expression was associated with increased immune infiltrates. Tumor cell MHCII expression positively correlated with immune cell infiltration and with STING- and YAP1 expressions.STING and MHCII are expressed in SCLC. The majority of immune-infiltrated SCLCs exhibit increased STING expression. Immune infiltration and STING expression are prognostic in limited-stage SCLC, making STING a potential therapeutic target. 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31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 2 2 2 2 2023 0 3 3 3 3 2024 0 5 5 5 5 2025 0 6 5 6 5 2026 0 5 5 5 5 D1 false 10044743,10050618 false false false 2022-11-20T14:11:18.752+0000 Anatómiai, Szövet- és Fejlődéstani Intézet (SE / AOK / I); Digitális Egészségtudományi Intézet (SE / EKK); Enzimológiai Intézet (TTK); Mellkassebészeti Klinika (SE / AOK / K); Országos Onkológiai Intézet; Tumorbiológiai Osztály (OKPI) 7 34 6 13 0 true 10014568 10073918 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 103191618 /api/authorship/103191618 1 0.077 true false false Author 10050618 /api/author/10050618 Dóra Dávid true 10050618 true Dora David true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103191619 /api/authorship/103191619 2 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/api/sjrrating/11396955 188 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true D1 DIRECT true true /api/publication/33060697 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10050618"><a href="/gui2/?type=authors&mode=browse&sel=10050618" target="_blank">Dora David (<span class="authorship-author-name">Dóra Dávid</span> <span class="authorAux-mtmt"> Fejlődésbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rivard Christopher </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yu Hui </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pickard Shivaun Lueke </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10037177"><a href="/gui2/?type=authors&mode=browse&sel=10037177" target="_blank">Laszlo Viktoria (<span class="authorship-author-name">László Viktória</span> <span class="authorAux-mtmt"> tumorbiologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Mellkassebészeti Klinika; <span title="Országos Korányi Pulmonológiai Intézet">OKPI</span>/Tumorbiológiai Osztály</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Harko Tunde </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071898"><a href="/gui2/?type=authors&mode=browse&sel=10071898" target="_blank">Megyesfalvi Zsolt (<span class="authorship-author-name">Megyesfalvi Zsolt</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Mellkassebészeti Klinika; <span title="Országos Korányi Pulmonológiai Intézet">OKPI</span>/Tumorbiológiai Osztály</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10084679"><a href="/gui2/?type=authors&mode=browse&sel=10084679" target="_blank">Gerdan Csongor (<span class="authorship-author-name">Gerdán Csongor</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet; <span title="Országos Korányi Pulmonológiai Intézet">OKPI</span>/Tumorbiológiai Osztály</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009579"><a href="/gui2/?type=authors&mode=browse&sel=10009579" target="_blank">Dinya Elek (<span class="authorship-author-name">Dinya Elek</span> <span class="authorAux-mtmt"> Orvosi biometria</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Egészségügyi Közszolgálati Kar">EKK</span>/Digitális Egészségtudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hoetzenecker Konrad </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hirsch Fred R </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10044743"><a href="/gui2/?type=authors&mode=browse&sel=10044743" target="_blank">Lohinai Zoltan<sup>**</sup> ✉ (<span class="authorship-author-name">Lohinai Zoltán</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Országos Korányi Pulmonológiai Intézet">OKPI</span>/Tumorbiológiai Osztály</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000046"><a href="/gui2/?type=authors&mode=browse&sel=10000046" target="_blank">Dome Balazs ✉ (<span class="authorship-author-name">Döme Balázs</span> <span class="authorAux-mtmt"> Tumor indukált angiogenezis</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Mellkassebészeti Klinika; <span title="Országos Korányi Pulmonológiai Intézet">OKPI</span>/Tumorbiológiai Osztály</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33060697" target="_blank">Protein Expression of immune checkpoints STING and MHCII in small cell lung cancer.</a></div> <div> <span class="journal-title">CANCER IMMUNOLOGY IMMUNOTHERAPY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1432-0851">1432-0851</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/0340-7004">0340-7004</a>)</span>: <span class="journal-volume">72</span> <span class="journal-issue">3</span> <span class="page"> pp 561-578 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s00262-022-03270-w" target="_blank" href="https://doi.org/10.1007/s00262-022-03270-w"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000842602400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000842602400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85137030185" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85137030185"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35978199" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35978199&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85137030185&doi=10.1007%2Fs00262-022-03270-w&partnerID=40&md5=cb4e16ae20f930c4020cefb299a62ee7" target="_blank" href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85137030185&doi=10.1007%2Fs00262-022-03270-w&partnerID=40&md5=cb4e16ae20f930c4020cefb299a62ee7"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology and Allergy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 21</span> | Független: 20 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 21 | Scopus jelölt:&nbsp;21 | WoS/Scopus jelölt:&nbsp;21 | DOI jelölt:&nbsp;21 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33060697&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33060697</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (124652) Támogató: OTKA, (129664) Támogató: OTKA, (2020-1.1.6-JOVO), (KH130356), (TKP2021-EGA-33), (ÚNKP-19-4), (ÚNKP-20-3), (UNKP-21-3) </div> <div class="lastModified">Utolsó módosítás: 2024.09.30. 01:15 Áts József (ÁtsJ adm2-3, admin) </div> <div class="lockedBy">Központi kezelésű 2023.10.04. 09:54 Kovács Marcell (MTMT Közp., admin) Vándor Andrea (VA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Hungarian National Research, Development and Innovation Office (OTKA) [124652, 129664]; Austrian Science Fund [FWF I3522, FWF I3977, I4677]; Hungarian National Research, Development and Innovation Office [KH130356, 2020-1.1.6-JoVO, TKP2021-EGA-33]; Bolyai Research Scholarship of the Hungarian Academy of Sciences; New National Excellence Program of the Ministry f...</pre> </div></div>