The roles of extracellular vesicles in the immune system

Buzas, Edit I. ✉ [Buzás, Edit Irén (Immunbiológia), szerző] Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I); MTA-SE Immun-proteogenomikai Extracelluláris Ve... (SE / AOK / I / GSII); HCEMM-SE Extracelluláris Vezikula Kutatócsoport (SE / AOK / I / GSII)

Angol nyelvű Összefoglaló cikk (Folyóiratcikk) Tudományos
Megjelent: NATURE REVIEWS IMMUNOLOGY 1474-1733 1474-1741 23 pp. 236-250 2023
  • SJR Scopus - Immunology: D1
Azonosítók
Támogatások:
  • (NVKP-16-1-2016-0017 National Heart Program) Támogató: NKFIH
  • (OTKA K120237)
  • (VEKOP-2.3.2-16-2016-000002)
  • (VEKOP-2.3.3-15-2017-00016)
  • (H2020-MSCA-ITN-2017-722148 TRAIN EV)
  • (739593) Támogató: Horizon 2020
  • (TKP2020-NKA-26)
The twenty-first century has witnessed major developments in the field of extracellular vesicle (EV) research, including significant steps towards defining standard criteria for the separation and detection of EVs. The recent recognition that EVs have the potential to function as biomarkers or as therapeutic tools has attracted even greater attention to their study. With this progress in mind, an updated comprehensive overview of the roles of EVs in the immune system is timely. This Review summarizes the roles of EVs in basic processes of innate and adaptive immunity, including inflammation, antigen presentation, and the development and activation of B cells and T cells. It also highlights key progress related to deciphering the roles of EVs in antimicrobial defence and in allergic, autoimmune and antitumour immune responses. It ends with a focus on the relevance of EVs to immunotherapy and vaccination, drawing attention to ongoing or recently completed clinical trials that aim to harness the therapeutic potential of EVs. Extracellular vesicles (EVs) are increasingly recognized as having ubiquitous roles in the immune system. This Review focuses on the progress made in the field in the past 5 years, including the roles of EVs in innate and adaptive immunity and their potential use in diagnosis and therapy.
Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
2024-07-17 21:31