https://m2.mtmt.hu/ hun 2026-09-22 06:42 JournalArticle 33053672 VALIDATED true 0 false 2026-05-22T02:22:28.008+0000 2022-09-26T11:06:02.364+0000 2022-08-16T18:58:32.042+0000 true 10018804 Szalóky-Siki Ágnes /api/admin/10018804 Admin true 10018804 2022-10-31T09:41:04.530+0000 2022-10-31T09:41:04.530+0000 2022-09-13T10:03:36.808+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Mukaddam, Khaled Cytokines Activate JAK–STAT Signaling Pathway in MG-63 Cells on Titanium and Zirconia true true /api/journal/10012997 REVIEWED true false 10012997 false 10012997 true 1996-1944 Journal FOREIGN 15 16 5621 5621 13 2022 Although titanium has been traditionally used as the gold standard for dental implants, recent years have seen the widespread application of zirconia implants given their superiority with regards to reduced bacterial adhesion, inflammation and cellular-interaction in terms of bio-compatibility. The JAK–STAT signaling pathway plays an important role in bone remodeling and formation. The aim of the study was to investigate the activation of the JAK–STAT pathway through different cytokines in osteoblast-like cells (MG-63) on zirconia in comparison to titanium discs. IFN-γ induced the very strong activation of STAT1 protein, IFN-α activated both STAT1 and STAT3 molecules, IL-6 activated STAT3 and IL-4 induced the activation of STAT6 on both surfaces. The activation of STAT proteins was confirmed by western blot, immunofluorescence and flow cytometry using phospho-specific anti-STAT antibodies, which recognize only phosphorylated STAT proteins. The incubation of MG-63 cells with IFN-γ caused the upregulation of MHC class I and class II proteins when MG-63 cells were grown on zirconia and titanium discs. In sum, the present study shows that the JAK–STAT pathway is activated in MG-63 cells when they are incubated on titanium or zirconia surfaces. true 2022 true true true false true false GOLD 2026-05-22 true https://doi.org/10.3390/ma15165621 4 0 4 2 0 4 4 4 3 4 4 2 2 2 2 0 4 2 4 2 0 0 0 Folyóiratcikk Journal Article 24 4 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 3 2 3 2 2025 0 1 0 1 0 Q2 false false false false 2022-09-12T10:02:55.008+0000 Fogpótlástani Klinika (SE / FOK) 2 8 1 10 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 103144730 /api/authorship/103144730 1 0.1 true false true Author 10084888 /api/author/10084888 Mukaddam Khaled true true Mukaddam Khaled true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103144731 /api/authorship/103144731 2 0.1 false false false Ruggiero Sabrina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103144732 /api/authorship/103144732 3 0.1 false false false Berger Steffen M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103144733 /api/authorship/103144733 4 0.1 false false false Cholewa Dietmar true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103144734 /api/authorship/103144734 5 0.1 false false false Kühl Sebastian true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103144735 /api/authorship/103144735 6 0.1 false false false Author 10059531 /api/author/10059531 Végh Dániel true 10059531 true Vegh Daniel true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103144736 /api/authorship/103144736 7 0.1 false false false Payer Michael true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103144737 /api/authorship/103144737 8 0.1 false false false Bornstein Michael M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103144738 /api/authorship/103144738 9 0.1 false false false Alhawasli Farah true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103144739 /api/authorship/103144739 10 0.1 false true true Fasler-Kan Elizaveta true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 21587588 /api/publicationidentifier/21587588 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ma15165621 https://doi.org/10.3390/ma15165621 false true PublicationIdentifier 21674742 /api/publicationidentifier/21674742 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000845677300001 https://www.webofscience.com/wos/woscc/full-record/000845677300001 true true PublicationIdentifier 21725423 /api/publicationidentifier/21725423 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus 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class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10084888"><a href="/gui2/?type=authors&mode=browse&sel=10084888" target="_blank">Mukaddam Khaled ✉ (<span class="authorship-author-name">Mukaddam Khaled</span> <span class="authorAux-mtmt"> Fogorvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Fogpótlástani Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ruggiero Sabrina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Berger Steffen M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Cholewa Dietmar </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kühl Sebastian </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10059531"><a href="/gui2/?type=authors&mode=browse&sel=10059531" target="_blank">Vegh Daniel (<span class="authorship-author-name">Végh Dániel</span> <span class="authorAux-mtmt"> Diabétesz és a szájüregi egészség kapcsolata</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Fogpótlástani Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Payer Michael </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bornstein Michael M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Alhawasli Farah </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Fasler-Kan Elizaveta ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33053672" target="_blank">Cytokines Activate JAK–STAT Signaling Pathway in MG-63 Cells on Titanium and Zirconia</a></div> <div> <span class="journal-title">MATERIALS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1996-1944">1996-1944</a>)</span>: <span class="journal-volume">15</span> <span class="journal-issue">16</span> <span class="page"> Paper 5621. 13 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ma15165621" target="_blank" href="https://doi.org/10.3390/ma15165621"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000845677300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000845677300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85137652839" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85137652839"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36013763" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36013763&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Condensed Matter Physics&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Materials Science (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 4</span> | Független: 2 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 4 | Scopus jelölt:&nbsp;3 | WoS/Scopus jelölt:&nbsp;4 | DOI jelölt:&nbsp;4 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33053672</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Bibtex</span> </div> <div class="lastModified">Utolsó módosítás: 2022.09.26. 13:06 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> </div></div>