https://m2.mtmt.hu/ hun 2026-03-16 07:17 JournalArticle 33050501 VALIDATED true 0 false 2026-01-02T01:20:45.875+0000 2022-09-12T06:52:46.740+0000 2022-08-15T08:37:07.496+0000 true 10020464 Homonnay Zalán Gábor /api/author/10020464 Author true 10020464 2025-07-07T13:15:47.857+0000 2025-07-07T13:15:47.857+0000 2022-09-12T06:52:46.948+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Felföldi, Balázs Glycoprotein Production by Bursal Secretory Dendritic Cells in Normal, Vaccinated, and Infectious Bursal Disease Virus (IBDV)-Infected Chickens true true /api/journal/10015873 REVIEWED true false 10015873 false 10015873 true 1999-4915 Journal FOREIGN 14 8 1689 1689 15 2022 The aim of this study is to follow the gp production in IBDV-vaccinated and challenged birds. The progress of IBDV infection was monitored using anti-VP2 immunocytochemistry, light and transmission electron microscopy. In the medulla of the bursal follicle, the Movat pentachrome staining discovered an extracellular glycoprotein (gp) produced by bursal secretory dendritic cells (BSDCs). The secretory granules of BSDCs either discharge resulting in extracellular gp or fuse together forming intracellular corpuscles. The double fate of granules suggests a dual function of BSDCs: (a.) For the discharged granules, gp contributes to the medullary microenvironment (ME). (b.) The intracellular corpuscles may be the sign of BSDC transformation to a macrophage-like cell (Mal). Infectious bursal disease virus (IBDV) infection accelerates the BSDC transformation to Mal. The decreased number of BSDCs is feedback for the precursor cells of BSDCs lodging in the cortico-medullary epithelial arches (CMEA), where they proliferate. Opening the CMEA, the precursor cells enter the medulla, and differentiate to immature BSDCs. The virus uptake in the corpuscles prevents the granular discharge resulting in the absence of gp and alteration in ME. In vaccine-take birds, the mitotic rate of BSDC precursor cells cannot restore the precursor pool; therefore, in the case of IBDV challenge, the number of newly formed BSDCs is too low for outbreak of clinical disease. The BSDCs, as a primary target of IBDV, may contribute to the long-lasting immunosuppressive status of IBDV-infected chickens. true 2022 true true true false true false GOLD 2026-01-02 true https://doi.org/10.3390/v14081689 1 0 1 0 1 1 1 1 1 1 1 0 0 0 1 0 1 0 1 0 0 8 8 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 0 1 0 Q1 false false false false 2022-09-11T06:52:46.491+0000 Anatómiai, Szövet- és Fejlődéstani Intézet (SE / AOK / I) 4 15 1 6 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 103129235 /api/authorship/103129235 1 0.16666667 true false false Felföldi Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103129236 /api/authorship/103129236 2 0.16666667 false false false Benyeda Zsófia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103129237 /api/authorship/103129237 3 0.167 false false false Author 10060030 /api/author/10060030 Kovács Tamás true 10060030 true Kovács Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103129238 /api/authorship/103129238 4 0.167 false false false Author 10012537 /api/author/10012537 Nagy Nándor true 10012537 true Nagy Nándor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103129239 /api/authorship/103129239 5 0.167 false false false Author 10018476 /api/author/10018476 Magyar Attila true 10018476 true Magyar Attila true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103129240 /api/authorship/103129240 6 0.167 false true true Author 10005243 /api/author/10005243 Oláh Imre true 10005243 true Oláh Imre true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 21579362 /api/publicationidentifier/21579362 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/v14081689 https://doi.org/10.3390/v14081689 false true PublicationIdentifier 21668236 /api/publicationidentifier/21668236 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS 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left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Felföldi Balázs </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Benyeda Zsófia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060030"><a href="/gui2/?type=authors&mode=browse&sel=10060030" target="_blank">Kovács Tamás (<span class="authorship-author-name">Kovács Tamás</span> <span class="authorAux-mtmt"> Molekuláris orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012537"><a href="/gui2/?type=authors&mode=browse&sel=10012537" target="_blank">Nagy Nándor (<span class="authorship-author-name">Nagy Nándor</span> <span class="authorAux-mtmt"> Fejlődésbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018476"><a href="/gui2/?type=authors&mode=browse&sel=10018476" target="_blank">Magyar Attila (<span class="authorship-author-name">Magyar Attila</span> <span class="authorAux-mtmt"> fejlődésbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10005243"><a href="/gui2/?type=authors&mode=browse&sel=10005243" target="_blank">Oláh Imre ✉ (<span class="authorship-author-name">Oláh Imre</span> <span class="authorAux-mtmt"> Immunológia - histológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33050501" target="_blank">Glycoprotein Production by Bursal Secretory Dendritic Cells in Normal, Vaccinated, and Infectious Bursal Disease Virus (IBDV)-Infected Chickens</a></div> <div> <span class="journal-title">VIRUSES</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1999-4915">1999-4915</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">8</span> <span class="page"> Paper 1689. 15 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id 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class="journal-subject">Folyóirat szakterülete: Scopus - Virology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 0 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33050501&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33050501</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2022.09.12. 08:52 Molnár-Taga Márta (SE 4-es admin) </div> </div></div>