https://m2.mtmt.hu/ eng 2026-06-13 03:10 JournalArticle 33044489 APPROVED true Institute for Clinical Diabetology, German Diabetes Centre, Leibniz Centre for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany Department of Endocrinology and Diabetology, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany German Centre for Diabetes Research, Partner Düsseldorf, München-Neuherberg, Germany Department of Diabetes, Monash University, Melbourne, VIC, Australia Export Date: 9 August 2022 Correspondence Address: Jandeleit-Dahm, K.; Department of Diabetes, Australia; email: Karin.jandeleit-dahm@monash.edu 0 false 2025-11-18T10:45:21.601+0000 2024-12-12T12:51:33.302+0000 2022-08-09T14:02:21.423+0000 true 10031137 Sonnevend Kinga /api/admin/10031137 Admin true 10031137 2025-11-18T10:43:19.460+0000 2025-11-15T16:14:03.829+0000 false false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Aboolian, A. Diabetic Kidney Disease: From Pathogenesis to Novel Treatment Possibilities true false /api/journal/39715 REVIEWED true false 39715 true 39715 true 0171-2004 1865-0325 Journal FOREIGN 274 269 307 269 39 2022 One of the microvascular complications of diabetes is diabetic kidney disease (DKD), often leading to end stage renal disease (ESRD) in which patients require costly dialysis or transplantation. The silent onset and irreversible progression of DKD are characterized by a steady decline of the estimated glomerular filtration rate, with or without concomitant albuminuria. The diabetic milieu allows the complex pathophysiology of DKD to enter a vicious cycle by inducing the synthesis of excessive amounts of reactive oxygen species (ROS) causing oxidative stress, inflammation, and fibrosis. As no cure is available, intensive research is required to develop novel treatments possibilities. This chapter provides an overview of the important pathomechanisms identified in diabetic kidney disease, the currently established therapies, as well as recently developed novel therapeutic strategies in DKD. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG. 2022 true true true false false NONE 2025-11-18 false 0 0 0 0 0 0 0 0 0 0 0 0 8 8 Q4 false false false false 2022-11-07T15:04:21.474+0000 26 95 0 5 0 false Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 103087991 /api/authorship/103087991 1 0.2 true false false Aboolian A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103087992 /api/authorship/103087992 2 0.2 false false false Urner S. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103087993 /api/authorship/103087993 3 0.2 false false false Roden M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true 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src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Aboolian A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Urner S. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Roden M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jha J.C. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jandeleit-Dahm K. ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33044489" target="_blank">Diabetic Kidney Disease: From Pathogenesis to Novel Treatment Possibilities</a></div> <div> <span class="journal-title">HANDBOOK OF EXPERIMENTAL PHARMACOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0171-2004">0171-2004</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1865-0325">1865-0325</a>)</span>: <span class="journal-volume">274</span> <span class="page"> pp 269-307 </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/164_2021_576" target="_blank" href="https://doi.org/10.1007/164_2021_576"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="001283235100015" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001283235100015"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85134855180" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85134855180"> Scopus </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33044489&sort=publishedYear,desc&sort=title"> Number of cited publications: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33044489</span> | <span class="status-data status-APPROVED"> Published </span> Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Last Modified: 2024.12.12. 13:51 Zóra Kondor (SE_KK_Admin5_KZ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Institute for Clinical Diabetology, German Diabetes Centre, Leibniz Centre for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany Department of Endocrinology and Diabetology, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany German Centre for Diabetes Research, Partner Düsseldorf, München-Neuherberg, ...</pre> </div></div>