https://m2.mtmt.hu/ hun 2026-09-20 22:56 JournalArticle 33042457 VALIDATED true 0 false 2026-06-16T06:50:40.245+0000 2025-10-14T09:08:39.492+0000 2022-08-08T12:30:50.675+0000 true 10071714 Lukácsné Varga Judit /api/admin/10071714 Admin Lukácsné Varga Judit (Testnevelési E. admin4) true 2025-10-14T09:08:39.673+0000 2025-10-14T09:08:39.673+0000 2022-08-19T10:05:17.342+0000 true 10071714 Lukácsné Varga Judit /api/admin/10071714 Admin Lukácsné Varga Judit (Testnevelési E. admin4) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Tóth, Kata true true /api/journal/10023304 REVIEWED FRONTIERS IN AGING NEUROSCIENCE 1663-4365 1663-4365 true false 10023304 false 10023304 true 1663-4365 1663-4365 Journal FOREIGN 14 854811 854811 11 2022 Acute cardiac damage can be induced by isoproterenol injections in animals. The associated inflammatory response could be reflected in the brain as neuroinflammation, with potential consequences for brain function and behavior. Although cardiac responses are reported age and sex-related, for neuroinflammation and brain function this is virtually unknown. Therefore, cardiac damage and its consequences for neuroinflammation, brain function and behavior were compared in aged male and female rats. Wistar rats of 24 months of age were treated with isoproterenol (ISO, twice s.c.) or saline. Four weeks after injections, exploratory behavior and short-term memory were tested. Then, rats were sacrificed. Hearts were collected to measure cardiac damage. Brain tissue was collected to obtain measures of neuroinflammation and brain function. In male-, but not in female rats, ISO induced significant cardiac damage. Accordingly, mortality was higher in males than in females. Baseline hippocampal microglia activity was lower in females, while ISO induced neuroinflammation in both sexes, Hippocampal brain-derived neurotrophic factor expression appeared lower in females, without effects of ISO. In the open field test, ISO-treated males, but not females, displayed anxiety-like behavior. No effects of ISO were observed on short-term memory in either sex. In conclusion, sex dimorphism in effects of ISO was observed for cardiac damage and open field behavior. However, these effects could not be related to differences in hippocampal neuroinflammation or neuronal function. true false INTERNATIONAL 2022 true true true false true false GOLD 2026-06-16 true https://doi.org/10.3389/fnagi.2022.854811 3 0 3 2 1 3 3 3 3 3 3 2 2 2 1 0 3 2 3 2 0 2 2 Folyóiratcikk Journal Article 24 3 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 0 1 0 2024 0 0 0 0 0 2025 0 1 1 1 1 2026 0 1 1 1 1 Q2 false false false false 2022-08-07T12:31:38.147+0000 Egészségtudományi Kar (SE); Magatartás-élettani Kutatólaboratórium (SE / ETK2007 / MFT); Magyar Testnevelési és Sporttudományi Egyetem; Molekuláris Edzésélettani Kutató Központ (MTSE / SETI); Sport- és egészségtudományi Kutatócsoport (EKKE / KUTE) 3 25 5 5 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 103077503 /api/authorship/103077503 Tóth, Kata [Tóth, Kata (Sporttudomány), szerző] Molekuláris Edzésélettani Kutató Központ (MTSE / SETI) 1 0.2 true false false Author 10055492 /api/author/10055492 Tóth Kata (Sporttudomány) Tóth Kata true 10055492 true Tóth Kata true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 103077504 /api/authorship/103077504 Oroszi, Tamás [Oroszi, Tamás (Sporttudomány), szerző] Molekuláris Edzésélettani Kutató Központ (MTSE / SETI); Magyar Testnevelési és Sporttudományi Egyetem 2 0.2 false false false Author 10063588 /api/author/10063588 Oroszi Tamás (Sporttudomány) Oroszi Tamás true 10063588 true Oroszi Tamás true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 103077505 /api/authorship/103077505 van der Zee, Eddy A. 3 0.2 false false false van der Zee Eddy A. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 103077506 /api/authorship/103077506 Nyakas, Csaba [Nyakas, Csaba (Molekuláris neuro...), szerző] Egészségtudományi Kar (SE); Magatartás-élettani Kutatólaboratórium (SE / ETK2007 / MFT); Molekuláris Edzésélettani Kutató Központ (MTSE / SETI); Sport- és egészségtudományi Kutatócsoport (EKKE / KUTE) 4 0.2 false false false Author 10010173 /api/author/10010173 Nyakas Csaba (Molekuláris neurobiológia) Nyakas Csaba true 10010173 true Nyakas Csaba true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 103077507 /api/authorship/103077507 Schoemaker, Regien G. ✉ 5 0.2 false true true Schoemaker Regien G. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 21552965 /api/publicationidentifier/21552965 DOI: 10.3389/fnagi.2022.854811 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3389/fnagi.2022.854811 https://doi.org/10.3389/fnagi.2022.854811 false true PublicationIdentifier 21599096 /api/publicationidentifier/21599096 WoS: 000837100600001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000837100600001 https://www.webofscience.com/wos/woscc/full-record/000837100600001 false true PublicationIdentifier 21586984 /api/publicationidentifier/21586984 Scopus: 85135447814 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85135447814 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85135447814 false true PublicationIdentifier 21599097 /api/publicationidentifier/21599097 PubMed: 35936761 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 35936761 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35936761&dopt=Abstract false true SjrRating 11282972 /api/sjrrating/11282972 sjr:Q2 (2022) Scopus - Aging FRONTIERS IN AGING NEUROSCIENCE 1663-4365 1663-4365 15 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1302 /api/classificationexternal/1302 Scopus - Aging true 1302 true Q2 DIRECT true true Reference 32707864 /api/reference/32707864 1. 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(2022) FRONTIERS IN AGING NEUROSCIENCE 1663-4365 1663-4365 14<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10055492"><a href="/gui2/?type=authors&mode=browse&sel=10055492" target="_blank">Tóth Kata (<span class="authorship-author-name">Tóth Kata</span> <span class="authorAux-mtmt"> Sporttudomány</span>) </a> </span> <span class="author-affil"><span title="Magyar Testnevelési és Sporttudományi Egyetem">MTSE</span>/<span title="Sport- és Egészségtudományi Intézet">SETI</span>/Molekuláris Edzésélettani Kutató Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10063588"><a href="/gui2/?type=authors&mode=browse&sel=10063588" target="_blank">Oroszi Tamás (<span class="authorship-author-name">Oroszi Tamás</span> <span class="authorAux-mtmt"> Sporttudomány</span>) </a> </span> <span class="author-affil"><span title="Magyar Testnevelési és Sporttudományi Egyetem">MTSE</span>/<span title="Sport- és Egészségtudományi Intézet">SETI</span>/Molekuláris Edzésélettani Kutató Központ; Magyar Testnevelési és Sporttudományi Egyetem</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >van der Zee Eddy A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010173"><a href="/gui2/?type=authors&mode=browse&sel=10010173" target="_blank">Nyakas Csaba (<span class="authorship-author-name">Nyakas Csaba</span> <span class="authorAux-mtmt"> Molekuláris neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/Egészségtudományi Kar; <span title="Semmelweis Egyetem">SE</span>/<span title="Egészségtudományi Kar">ETK2007</span>/<span title="Morfológiai és Fiziológiai Tanszék">MFT</span>/Magatartás-élettani Kutatólaboratórium; <span title="Magyar Testnevelési és Sporttudományi Egyetem">MTSE</span>/<span title="Sport- és Egészségtudományi Intézet">SETI</span>/Molekuláris Edzésélettani Kutató Központ; <span title="Eszterházy Károly Katolikus Egyetem">EKKE</span>/<span title="Kutatási egységek">KUTE</span>/Sport- és egészségtudományi Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schoemaker Regien G. ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33042457" target="_blank">Sex dimorphism in isoproterenol-induced cardiac damage associated neuroinflammation and behavior in old rats</a></div> <div> <span class="journal-title">FRONTIERS IN AGING NEUROSCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1663-4365">1663-4365</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1663-4365">1663-4365</a>)</span>: <span class="journal-volume">14</span> <span class="page"> Paper 854811. 11 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fnagi.2022.854811" target="_blank" href="https://doi.org/10.3389/fnagi.2022.854811"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000837100600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000837100600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85135447814" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85135447814"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35936761" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35936761&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Aging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cognitive Neuroscience&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 3</span> | Független: 2 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 3 | Scopus jelölt:&nbsp;3 | WoS/Scopus jelölt:&nbsp;3 | DOI jelölt:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33042457&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33042457</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2025.10.14. 11:08 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> </div></div>