https://m2.mtmt.hu/ eng 2026-10-24 04:11 JournalArticle 33038242 VALIDATED true Export Date: 16 January 2023 Correspondence Address: Neilan, T.G.; Cardio-Oncology Program and Cardiovascular Imaging Research Center, 165 Cambridge Street, Suite 400, United States; email: tneilan@mgh.harvard.edu Chemicals/CAS: glucose, 50-99-7, 84778-64-3; sodium, 7440-23-5; Anthracyclines; Glucose; Sodium; Sodium-Glucose Transporter 2 Inhibitors; Symporters 0 false 2026-10-22T15:39:08.112+0000 2022-10-19T11:31:36.558+0000 2022-08-03T13:04:51.754+0000 true 10061268 Drobni Zsófia /api/author/10061268 Author true 10061268 2024-10-08T07:36:21.556+0000 2024-10-08T07:36:21.556+0000 2022-10-19T11:31:36.767+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Gongora, Carlos A Sodium-Glucose Co-Transporter-2 Inhibitors and Cardiac Outcomes Among Patients Treated With Anthracyclines. true true /api/journal/10036137 REVIEWED true false 10036137 false 10036137 true 2213-1779 2213-1787 Journal FOREIGN 10 8 559 567 559 9 2022 Sodium-glucose co-transporter-2 (SGLT2) inhibitors improve outcomes among patients with established heart failure. Despite supportive basic science studies, there are no data on the value of SGLT2 inhibitors among patients treated with anthracyclines.This study sought to test the cardiac efficacy and overall safety of SGLT2 inhibitors in patients treated with anthracyclines.This study identified 3,033 patients with diabetes mellitus (DM) and cancer who were treated with anthracyclines. Cases were patients with cancer and DM who were on SGLT2 inhibitor therapy during anthracycline treatment (n = 32). Control participants (n = 96) were patients with cancer and DM who were also treated with anthracyclines, but were not on an SGLT2 inhibitor. The primary cardiac outcome was a composite of cardiac events (heart failure incidence, heart failure admissions, new cardiomyopathy [>10% decline in ejection fraction to <53%], and clinically significant arrhythmias). The primary safety outcome was overall mortality.Age, sex, ethnicity, cancer type, cancer stage, and other cardiac risk factors were similar between groups. There were 20 cardiac events over a median follow-up period of 1.5 years. The cardiac event incidence was lower among case patients in comparison to control participants (3% vs 20%; P = 0.025). Case patients also experienced lower overall mortality when compared with control participants (9% vs 43%; P < 0.001) and a lower composite of sepsis and neutropenic fever (16% vs 40%; P = 0.013).SGLT2 inhibitors were associated with lower rate of cardiac events among patients with cancer and DM who were treated with anthracyclines. Additionally, SGLT2 inhibitors appeared to be safe. These data support the conducting of a randomized clinical trial testing SGLT2 inhibitors in patients at high cardiac risk treated with anthracyclines. 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false false false 2022-08-03T12:36:58.265+0000 Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K); Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 1 13 2 19 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 103053966 /api/authorship/103053966 1 0.05263158 true false false Gongora Carlos A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103053967 /api/authorship/103053967 2 0.053 false false false Author 10061268 /api/author/10061268 Drobni Zsófia true 10061268 true Drobni Zsofia D true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103053968 /api/authorship/103053968 3 0.05263158 false false false Quinaglia Araujo Costa Silva Thiago true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103053969 /api/authorship/103053969 4 0.05263158 false false false Zafar Amna true false false AuthorshipType 1 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10 0.05263158 false false false Nikolaidou Sofia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103053976 /api/authorship/103053976 11 0.05263158 false false false Suero-Abreu Giselle Alexandra true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103053977 /api/authorship/103053977 12 0.05263158 false false false Jacobsen Eric true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103053978 /api/authorship/103053978 13 0.05263158 false false false Abramson Jeremy S true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103053979 /api/authorship/103053979 14 0.05263158 false false false Hochberg Ephraim true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103053980 /api/authorship/103053980 15 0.05263158 false false false Barnes Jeffrey true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103053981 /api/authorship/103053981 16 0.05263158 false false false Armand Philippe true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103053982 /api/authorship/103053982 17 0.05263158 false false false Thavendiranathan Paaladinesh true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103053983 /api/authorship/103053983 18 0.05263158 false false false Nohria Anju true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103053984 /api/authorship/103053984 19 0.053 false true true Neilan Tomas G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 21536196 /api/publicationidentifier/21536196 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI 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PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 35902159 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35902159&dopt=Abstract false true Classification 12139 /api/classification/12139 true true Keyword 14018 /api/keyword/14018 true 14018 true Keyword 15030 /api/keyword/15030 true 15030 true Keyword 1495408 /api/keyword/1495408 true true Keyword 1527283 /api/keyword/1527283 true true Keyword 2571480 /api/keyword/2571480 true true Keyword 2727981 /api/keyword/2727981 true true SjrRating 11311713 /api/sjrrating/11311713 6 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2705 /api/classificationexternal/2705 true 2705 true D1 DIRECT true true /api/publication/33038242 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Gongora Carlos A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061268"><a href="/gui2/?type=authors&mode=browse&sel=10061268" target="_blank">Drobni Zsofia D (<span class="authorship-author-name">Drobni Zsófia</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Quinaglia Araujo Costa Silva Thiago </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zafar Amna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gong Jingyi </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zlotoff Daniel A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gilman Hannah K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hartmann Sarah E </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sama Supraja </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nikolaidou Sofia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Suero-Abreu Giselle Alexandra </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jacobsen Eric </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Abramson Jeremy S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hochberg Ephraim </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Barnes Jeffrey </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Armand Philippe </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Thavendiranathan Paaladinesh </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nohria Anju </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Neilan Tomas G ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33038242" target="_blank">Sodium-Glucose Co-Transporter-2 Inhibitors and Cardiac Outcomes Among Patients Treated With Anthracyclines.</a></div> <div> <span class="journal-title">JACC-HEART FAILURE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2213-1779">2213-1779</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2213-1787">2213-1787</a>)</span>: <span class="journal-volume">10</span> <span class="journal-issue">8</span> <span class="page"> pp 559-567 </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.jchf.2022.03.006" target="_blank" href="https://doi.org/10.1016/j.jchf.2022.03.006"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000861627800006" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000861627800006"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85134732643" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85134732643"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35902159" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35902159&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 147</span> | Independent citation: 139 | Self citation: 8 | Unknown citation: 0 | Number of citations in WoS: 132 | Number of citations in Scopus:&nbsp;137 | WoS/Scopus assigned:&nbsp;147 | Number of citations with DOI:&nbsp;146 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33038242&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33038242</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (ÚNKP-21-4-I-SE) </div> <div class="lastModified">Last Modified: 2022.10.19. 13:31 Ágnes Szalóky-Siki (SE_KK_Admin5_SZSA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Export Date: 16 January 2023 Correspondence Address: Neilan, T.G.; Cardio-Oncology Program and Cardiovascular Imaging Research Center, 165 Cambridge Street, Suite 400, United States; email: tneilan@mgh.harvard.edu Chemicals/CAS: glucose, 50-99-7, 84778-64-3; sodium, 7440-23-5; Anthracyclines; Glucose; Sodium; Sodium-Glucose Transporter 2 Inhibitor...</pre> </div></div>