https://m2.mtmt.hu/ eng 2026-04-21 12:00 JournalArticle 33032862 VALIDATED true Department of Pulmonology, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Genetics, Cell- and Immunobiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary Division of Infection, Immunity & Respiratory Medicine, University of Manchester, Manchester, United Kingdom Department of Thoracic Surgery, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Thoracic Surgery, National Institute of Oncology, Budapest, Hungary Export Date: 18 November 2022 Correspondence Address: Jáky-Kováts, Z.; Department of Pulmonology, Hungary; email: kovats.zsuzsanna@med.semmelweis-univ.hu 0 false 2026-02-16T11:01:35.096+0000 2022-12-27T21:29:19.099+0000 2022-07-29T19:58:20.582+0000 true 10023975 Bikov András /api/author/10023975 Author true 10023975 2026-02-16T10:57:46.668+0000 2026-02-16T10:57:46.668+0000 2022-08-04T07:51:31.461+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Jaky-Kovats, Zsuzsanna Peripheral blood and bronchoalveolar leukocyte profile in lung transplant recipients and their changes according to immunosuppressive regimen: A single-center experience true true /api/journal/10044942 REVIEWED true false 10044942 false 10044942 true 2050-4527 Journal FOREIGN 10 8 e673 e673 8 2022 Background: After lung transplantation (LuTX), lower respiratory tract infections (LRTI) and acute cellular rejection (ACR) are associated with changes in peripheral blood and bronchoalveolar lavage fluid mononuclear cell profile (PBMC and BALIC). PBMC is also influenced by immunosuppressive regimen and its changes with postoperative time. First-year PBMC and BALIC changes were evaluated in this study with rabbit anti-thymocyte globulin (ATG) and alemtuzumab (AL) induction therapy. Methods: In total, 64 LuTX recipients were included, 53 of them received AL and 11 ATG as induction therapy. PBMC and BALIC were examined routinely and in cases suspicious of infection and/or rejection. A PBMC- and BALIC-based algorithm for infection and rejection prediction was also tested. Results: In the AL group, peripheral blood lymphocyte and basophil cell numbers were significantly reduced, while the neutrophil cell number elevation during LRTI was significantly higher compared to the control. Early postoperative measurements showed a lower BALIC lymphocyte count. The algorithm had 17% sensitivity and 94% specificity for ACR in all patients and 33% sensitivity and 95% specificity for ACR with coexisting LRTI. Conclusion: BALIC is not significantly influenced by the immunosuppressive regimen. PBMC- and BALIC-based algorithm may improve the differential diagnosis of ACR. Funding 2016381 /api/funding/2016381 false true true 2022 true true true false true false GOLD 2026-02-16 true https://doi.org/10.1002/iid3.673 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 Q3 false 10026923,10024104,10023927 false false false 2022-08-03T07:51:31.154+0000 Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I); Mellkassebészeti Klinika (SE / AOK / K); Országos Onkológiai Intézet; Pulmonológiai Klinika (SE / AOK / K) 8 18 4 8 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 103021403 /api/authorship/103021403 1 0.125 true false true Author 10023927 /api/author/10023927 Jáky-Kováts Zsuzsanna Ágnes true 10023927 true Jaky-Kovats Zsuzsanna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103021404 /api/authorship/103021404 2 0.125 false false false Author 10069041 /api/author/10069041 Vámos Melinda true true Vamos Melinda true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103021405 /api/authorship/103021405 3 0.125 false false false Author 10026923 /api/author/10026923 Komlósi Zsolt true 10026923 true Komlosi Zsolt Istvan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103021406 /api/authorship/103021406 4 0.125 false false false Author 10023975 /api/author/10023975 Bikov András true 10023975 true Bikov Andras true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103021407 /api/authorship/103021407 5 0.125 false false false Author 10069010 /api/author/10069010 Madurka Ildikó Eszter true true Madurka Ildiko true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103021408 /api/authorship/103021408 6 0.125 false false false Author 10067712 /api/author/10067712 Szűcs Gergő true true Szucs Gergo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103021409 /api/authorship/103021409 7 0.125 false false false Author 10012282 /api/author/10012282 Müller Veronika true 10012282 true Muller Veronika true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 103021410 /api/authorship/103021410 8 0.125 false true false Author 10024104 /api/author/10024104 Bohács Anikó true 10024104 true Bohacs Aniko true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 21511474 /api/publicationidentifier/21511474 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1002/iid3.673 https://doi.org/10.1002/iid3.673 false true PublicationIdentifier 21511475 /api/publicationidentifier/21511475 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS 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/api/reference/32515781 21 false true /api/publication/33032862 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10023927"><a href="/gui2/?type=authors&mode=browse&sel=10023927" target="_blank">Jaky-Kovats Zsuzsanna ✉ (<span class="authorship-author-name">Jáky-Kováts Zsuzsanna Ágnes</span> <span class="authorAux-mtmt"> Pulmonológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Pulmonology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10069041"><a href="/gui2/?type=authors&mode=browse&sel=10069041" target="_blank">Vamos Melinda (<span class="authorship-author-name">Vámos Melinda</span> <span class="authorAux-mtmt"> Pulmonológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Pulmonology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026923"><a href="/gui2/?type=authors&mode=browse&sel=10026923" target="_blank">Komlosi Zsolt Istvan (<span class="authorship-author-name">Komlósi Zsolt</span> <span class="authorAux-mtmt"> Pulmonológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Pulmonology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Genetics, Cell- and Immunology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023975"><a href="/gui2/?type=authors&mode=browse&sel=10023975" target="_blank">Bikov Andras (<span class="authorship-author-name">Bikov András</span> <span class="authorAux-mtmt"> Pulmonológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Pulmonology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10069010"><a href="/gui2/?type=authors&mode=browse&sel=10069010" target="_blank">Madurka Ildiko (<span class="authorship-author-name">Madurka Ildikó Eszter</span> <span class="authorAux-mtmt"> aneszteziológia</span>) </a> </span> <span class="author-affil">National Institute of Oncology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Thoracic Surgery</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10067712"><a href="/gui2/?type=authors&mode=browse&sel=10067712" target="_blank">Szucs Gergo (<span class="authorship-author-name">Szűcs Gergő</span> <span class="authorAux-mtmt"> Klinikai Laboratóriumi Kutató</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Pulmonology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012282"><a href="/gui2/?type=authors&mode=browse&sel=10012282" target="_blank">Muller Veronika (<span class="authorship-author-name">Müller Veronika</span> <span class="authorAux-mtmt"> Pulmonológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Pulmonology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024104"><a href="/gui2/?type=authors&mode=browse&sel=10024104" target="_blank">Bohacs Aniko (<span class="authorship-author-name">Bohács Anikó</span> <span class="authorAux-mtmt"> Pulmonológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Pulmonology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33032862" target="_blank">Peripheral blood and bronchoalveolar leukocyte profile in lung transplant recipients and their changes according to immunosuppressive regimen: A single-center experience</a></div> <div> <span class="journal-title">IMMUNITY INFLAMMATION AND DISEASE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2050-4527">2050-4527</a>)</span>: <span class="journal-volume">10</span> <span class="journal-issue">8</span> <span class="page"> Paper e673. 8 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1002/iid3.673" target="_blank" href="https://doi.org/10.1002/iid3.673"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000827553500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000827553500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85134933394" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85134933394"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35894710" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35894710&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Immunology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> <div class="journal-subject">Journal subject: Scopus - Immunology and Allergy&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33032862&sort=publishedYear,desc&sort=title"> Number of cited publications: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33032862</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> (Semmelweis University) </div> <div class="lastModified">Last Modified: 2022.12.27. 22:29 Éva Pécsi (MTMT Közp 2,3, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Pulmonology, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Genetics, Cell- and Immunobiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary Division of Infection, Immunity & Respiratory Medicine, University of Manchester, Manchester, United Kingdom Department of Th...</pre> </div></div>