https://m2.mtmt.hu/ hun 2026-07-26 10:51 JournalArticle 32993735 VALIDATED true 0 false 2022-07-29T15:48:23.557+0000 2022-07-18T15:03:41.998+0000 2022-07-18T15:03:40.526+0000 true 568 Áts József /api/admin/568 Admin true 2022-07-18T15:03:40.415+0000 2022-07-18T15:03:40.415+0000 2022-07-18T15:03:40.770+0000 true 568 Áts József /api/admin/568 Admin true false false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Davies, Hannah A. Rapid evaporative ionization mass spectrometry (intelligent knife) for point-of-care testing in acute aortic dissection surgery true true /api/journal/10028634 REVIEWED true false 10028634 false 10028634 true 1569-9293 1569-9285 Journal FOREIGN 34 5 833 840 833 8 2022 OBJECTIVES: Rapid evaporative ionization mass spectrometry (REIMS) can discriminate aneurysmal from normal aortic tissue. Our objective in this work was to probe the integrity of acute dissection tissue using biomechanical, biochemical and histological techniques and demonstrate that REIMS can be used to discriminate identified differences.METHODS: Human aortic tissue was obtained from patients undergoing surgery for acute aortic dissection. Biomechanical, biochemical and histological assessment was carried out to probe mechanical properties and elastin, collagen and glycosaminoglycan composition of the tissue. Monopolar electrocautery was applied to samples and surgical aerosol aspirated and analysed by REIMS to produce mass spectral data.RESULTS: Tissue was obtained from 10 patients giving rise to 26 tissue pieces: 10 false lumen (FL), 10 dissection flap and 6 true lumen samples. Models generated from biomechanical and biochemical data showed that FL tissue was distinct from true lumen and dissection flap tissue. REIMS identified the same pattern being able to classify tissue types with 72.4% accuracy and 69.3% precision. Further analysis of REIMS data for FL tissue suggested patients formed 3 distinct clusters. Histological and biochemical assessment revealed patterns of extracellular matrix degradation within the clusters that are associated with altered tissue integrity identified using biomechanical testing.CONCLUSIONS: Structural integrity of the FL in acute Type A dissection could dictate future clinical distal disease progression. REIMS can detect differences in tissue integrity, supporting its development as a point-of-care test to guide surgical intraoperative decision-making. 2022 true true true false false GOLD 2022-07-29 false http://icvts.oxfordjournals.org/ 0 0 0 0 0 0 0 0 0 0 0 0 1 1 Q2 false false false false 3 7 0 10 0 false Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 102747299 /api/authorship/102747299 1 0.1 true false false Davies Hannah A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102747300 /api/authorship/102747300 2 0.1 false false false Caamano-Gutierrez Eva true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102747301 /api/authorship/102747301 3 0.1 false false false Sarsby Joscelyn true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102747302 /api/authorship/102747302 4 0.1 false false false Chim Ya Hua true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102747303 /api/authorship/102747303 5 0.1 false false false Barrett Steve true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102747304 /api/authorship/102747304 6 0.1 false false false Nawaytou Omar true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102747305 /api/authorship/102747305 7 0.1 false false false Harky Amer true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102747306 /api/authorship/102747306 8 0.1 false false false Field Mark true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102747307 /api/authorship/102747307 9 0.1 false false false Akhtar Riaz true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102747308 /api/authorship/102747308 10 0.1 false true true Madine Jillian true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 21408618 /api/publicationidentifier/21408618 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true 10.1093/icvts/ivac019 https://doi.org/10.1093%2Ficvts%2Fivac019 false true PublicationIdentifier 21408617 /api/publicationidentifier/21408617 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=CustomerName&SrcApp=CustomerName&DestLinkType=FullRecord&KeyUT=@@@&DestApp=WOS true true 1 true IDENTICAL 000790937500018 http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=CustomerName&SrcApp=CustomerName&DestLinkType=FullRecord&KeyUT=000790937500018&DestApp=WOS false true Classification 12215 /api/classification/12215 true true Keyword 9013 /api/keyword/9013 true 9013 true Keyword 1005199 /api/keyword/1005199 true 1005199 true Keyword 1512168 /api/keyword/1512168 true true Keyword 1534599 /api/keyword/1534599 true true Keyword 1656056 /api/keyword/1656056 true true Keyword 1894715 /api/keyword/1894715 true true SjrRating 11319028 /api/sjrrating/11319028 191 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2746 /api/classificationexternal/2746 true 2746 true Q2 FROM_LAST_YEAR true true /api/publication/32993735 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Davies Hannah A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Caamano-Gutierrez Eva </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sarsby Joscelyn </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Chim Ya Hua </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Barrett Steve </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nawaytou Omar </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Harky Amer </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Field Mark </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Akhtar Riaz </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Madine Jillian ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32993735" target="_blank">Rapid evaporative ionization mass spectrometry (intelligent knife) for point-of-care testing in acute aortic dissection surgery</a></div> <div> <span class="journal-title">INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1569-9293">1569-9293</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1569-9285">1569-9285</a>)</span>: <span class="journal-volume">34</span> <span class="journal-issue">5</span> <span class="page"> pp 833-840 </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1093/icvts/ivac019" target="_blank" href="https://doi.org/10.1093%2Ficvts%2Fivac019"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000790937500018" target="_blank" href="http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=CustomerName&SrcApp=CustomerName&DestLinkType=FullRecord&KeyUT=000790937500018&DestApp=WOS"> WoS </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32993735&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32993735</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WoS-XML</span> </div> <div class="lastModified">Utolsó módosítás: 2022.07.18. 17:03 Áts József (admin) </div> </div></div>