https://m2.mtmt.hu/ eng 2026-10-25 10:09 JournalArticle 32990270 VALIDATED true * Megosztott szerzőség Protocol 0 false 2026-10-22T14:57:20.389+0000 2023-09-02T13:59:23.544+0000 2022-07-18T08:16:19.753+0000 true 10081959 Szalóky-Siki Ágnes /api/admin/10081959 Admin true 2026-09-07T11:43:40.075+0000 2023-09-02T13:59:24.007+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Sebők, Judit Effect of HEAT therapy in patiEnts with type 2 Diabetes mellitus (HEATED) : protocol for a randomised controlled trial true true /api/journal/10024941 REVIEWED true false 10024941 false 10024941 true 2044-6055 2044-6055 Journal FOREIGN 12 7 e062122 e062122 7 2022 The burden of type 2 diabetes mellitus (T2DM) is increasing worldwide. Heat therapy has been found effective in improving glycaemic control. However, to date, there is a lack of randomised controlled studies investigating the efficacy of heat therapy in T2DM. Therefore, we aim to investigate whether heat therapy with natural thermal mineral water can improve glycaemic control in patients with T2DM.The HEAT therapy in patiEnts with type 2 Diabetes mellitus (HEATED) Study is a single-centre, two-arm randomised controlled trial being conducted at Harkány Thermal Rehabilitation Centre in Hungary. Patients with T2DM will be randomly assigned to group A (bath sessions in 38°C natural thermal mineral water) and group B (baths in thermoneutral water (30°C-32°C)). Both groups will complete a maximum of 5 weekly visits, averaging 50-60 visits over the 12-week study. Each session will last 30 min, with a physical check-up before the bath. At baseline, patients' T2DM status will be investigated thoroughly. Possible microvascular and macrovascular complications of T2DM will be assessed with physical and laboratory examinations. The short form-36 questionnaire will assess the quality of life. Patients will also be evaluated at weeks 4, 8 and 12. The primary endpoint will be the change of glycated haemoglobin from baseline to week 12. An estimated 65 patients will be enrolled per group, with a sample size re-estimation at the enrolment of 50% of the calculated sample size.The study has been approved by the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (818-2/2022/EÜIG). Written informed consent is required from all participants. We will disseminate our results to the medical community and will publish our results in peer-reviewed journals.ClinicalTrials.gov, NCT05237219. Funding 2016490 /api/funding/2016490 false true true 2022 true true true false true false GOLD 2026-10-22 true https://doi.org/10.1136/bmjopen-2022-062122 7 0 5 4 0 5 3 3 2 3 3 2 2 6 1 0 7 6 5 4 0 8 8 Folyóiratcikk Journal Article 24 5 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 2 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 1 1 1 2024 0 3 3 3 3 2025 0 0 0 0 0 2026 0 3 2 3 2 Q1 false 10024901,10048551 false false false 2022-07-17T08:23:51.466+0000 Bioanalitikai Intézet (PTE / ÁOK); Biokémiai és Orvosi Kémiai Intézet (PTE / ÁOK); II. sz. Belgyógyászati Klinika és Nephrológiai,... (PTE / ÁOK); Pankreász Betegségek Részlege (SE / AOK / K); Transzlációs Medicina Intézet (PTE / ÁOK); Transzlációs Medicina Központ (SE / KSZE); Transzlációs medicina kutatócsoport (PTE / SZKK); Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 15 54 8 18 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 102725492 /api/authorship/102725492 1 0.055555556 true false false Author 10016601 /api/author/10016601 Sebők Judit true 10016601 true Sebők Judit true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102725493 /api/authorship/102725493 2 0.055555556 false false false Author 10016451 /api/author/10016451 Édel Zsófia true 10016451 true Édel Zsófia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102725494 /api/authorship/102725494 3 0.056 false false false Author 10070652 /api/author/10070652 Dembrovszky Fanni true true Dembrovszky Fanni true false 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IDENTICAL 35820741 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35820741&dopt=Abstract false true PublicationIdentifier 31917874 /api/publicationidentifier/31917874 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true IDENTICAL https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2022-062122 https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2022-062122 false true Keyword 1029034 /api/keyword/1029034 true 1029034 true Keyword 1528371 /api/keyword/1528371 true true Keyword 1599819 /api/keyword/1599819 true true SjrRating 11309423 /api/sjrrating/11309423 435 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true Q1 DIRECT true true /api/publication/32990270 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10016601"><a href="/gui2/?type=authors&mode=browse&sel=10016601" target="_blank">Sebők Judit (<span class="authorship-author-name">Sebők Judit</span> <span class="authorAux-mtmt"> Belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Second Department of Medicine and Nephrology-Diabetes Centre</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10016451"><a href="/gui2/?type=authors&mode=browse&sel=10016451" target="_blank">Édel Zsófia (<span class="authorship-author-name">Édel Zsófia</span> <span class="authorAux-mtmt"> Belgyógyászat, nephrológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Second Department of Medicine and Nephrology-Diabetes Centre</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10070652"><a href="/gui2/?type=authors&mode=browse&sel=10070652" target="_blank">Dembrovszky Fanni (<span class="authorship-author-name">Dembrovszky Fanni</span> <span class="authorAux-mtmt"> Általános orvos</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Translational Medicine Research Group; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015357"><a href="/gui2/?type=authors&mode=browse&sel=10015357" target="_blank">Farkas Nelli (<span class="authorship-author-name">Borbásné Farkas Kornélia</span> <span class="authorAux-mtmt"> Membránbiokémia, biostatisztika</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute of Bioanalysis; <span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Translational Medicine Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013663"><a href="/gui2/?type=authors&mode=browse&sel=10013663" target="_blank">Török Zsolt (<span class="authorship-author-name">Török Zsolt</span> <span class="authorAux-mtmt"> Membrán biofizika</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024899"><a href="/gui2/?type=authors&mode=browse&sel=10024899" target="_blank">Balogh Gábor (<span class="authorship-author-name">Balogh Gábor</span> <span class="authorAux-mtmt"> biokémia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025206"><a href="/gui2/?type=authors&mode=browse&sel=10025206" target="_blank">Péter Mária (<span class="authorship-author-name">Péter Mária</span> <span class="authorAux-mtmt"> biokémia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Papp Ildiko </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024901"><a href="/gui2/?type=authors&mode=browse&sel=10024901" target="_blank">Balogi Zsolt (<span class="authorship-author-name">Balogi Zsolt</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Biochemistry and Medical Chemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048551"><a href="/gui2/?type=authors&mode=browse&sel=10048551" target="_blank">Nusser Nóra (<span class="authorship-author-name">Csizmadiáné Nusser Nóra</span> <span class="authorAux-mtmt"> Orvos</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025673"><a href="/gui2/?type=authors&mode=browse&sel=10025673" target="_blank">Péter Iván (<span class="authorship-author-name">Péter Iván</span> <span class="authorAux-mtmt"> Bőrgyógyászat</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hooper Philip </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Geiger Paige </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064235"><a href="/gui2/?type=authors&mode=browse&sel=10064235" target="_blank">Erőss Bálint (<span class="authorship-author-name">Erőss Bálint Mihály</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center; <span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Translational Medicine Research Group; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Pancreatic Diseases</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10016656"><a href="/gui2/?type=authors&mode=browse&sel=10016656" target="_blank">Wittmann István (<span class="authorship-author-name">Wittmann István</span> <span class="authorAux-mtmt"> Klinikai orvostudomány</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Second Department of Medicine and Nephrology-Diabetes Centre</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071961"><a href="/gui2/?type=authors&mode=browse&sel=10071961" target="_blank">Váncsa Szilárd<sup>**</sup> (<span class="authorship-author-name">Váncsa Szilárd</span> <span class="authorAux-mtmt"> Orvostudomány, egészségtudomány</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Translational Medicine Research Group; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1035720"><a href="/gui2/?type=authors&mode=browse&sel=1035720" target="_blank">Vigh László<sup>**</sup> (<span class="authorship-author-name">Vigh László</span> <span class="authorAux-mtmt"> Membránbiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Péter ✉ (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Translational Medicine Research Group; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32990270" target="_blank">Effect of HEAT therapy in patiEnts with type 2 Diabetes mellitus (HEATED) : protocol for a randomised controlled trial</a></div> <div> <span class="journal-title">BMJ OPEN</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2044-6055">2044-6055</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2044-6055">2044-6055</a>)</span>: <span class="journal-volume">12</span> <span class="journal-issue">7</span> <span class="page"> Paper e062122. 7 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1136/bmjopen-2022-062122" target="_blank" href="https://doi.org/10.1136/bmjopen-2022-062122"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000824496500006" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000824496500006"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85133931347" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85133931347"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35820741" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35820741&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2022-062122" target="_blank" href="https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2022-062122"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 7</span> | Independent citation: 6 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 3 | Number of citations in Scopus:&nbsp;2 | WoS/Scopus assigned:&nbsp;3 | Number of citations with DOI:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32990270&sort=publishedYear,desc&sort=title"> Number of cited publications: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32990270</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (GINOP-2.3.4-15-2020-00010) </div> <div class="lastModified">Last Modified: 2023.09.02. 15:59 Róbert Milánkovics (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: * Megosztott szerzőség Protocol</pre> </div></div>