https://m2.mtmt.hu/ hun 2026-05-31 15:43 JournalArticle 32980571 APPROVED true Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary Department of Physiology, Semmelweis University, Budapest, Hungary Institute of Organic Chemistry, Eötvös Loránd Research Network, Research Centre for Natural Sciences, Budapest, Hungary Department of Biochemistry, Semmelweis University, Budapest, Hungary Eötvös Loránd Research Network and Semmelweis University (ELKH-SE) Laboratory of Molecular Physiology, Eötvös Loránd Research Network, Budapest, Hungary Department of Radiology, Medical Imaging Centre, Semmelweis University, Budapest, Hungary Eötvös Loránd Research Network and Semmelweis University (ELKH-SE) Immune-Proteogenomics Research Group, Budapest, Hungary Hungarian Centre of Excellence for Molecular Medicine - Semmelweis University (HCEMM-SU) Extracellular Vesicles Research Group, Budapest, Hungary Institute of Enzymology, Eötvös Loránd Research Network, Research Centre for Natural Sciences, Budapest, Hungary Department of Rheumatology and Clinical Immunology, Department of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary Heart and Vascular Centre, Semmelweis University, Budapest, Hungary Export Date: 3 October 2022 Correspondence Address: Turu, G.; Department of Physiology, Hungary; email: turu.gabor@med.semmelweis-univ.hu 0 false 2026-05-22T00:51:34.130+0000 2025-02-25T23:23:33.839+0000 2022-07-17T15:53:22.192+0000 true 10071338 Molnár-Taga Márta /api/admin/10071338 Admin Molnár-Taga Márta (SE_AOK_1Bel_Onkol_Admin5_MTM, admin) true 2026-05-14T11:22:07.987+0000 2026-05-14T11:22:07.987+0000 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv (MTMT API user, admin) Ladányi Gusztáv true true Admin 10014568 /api/admin/10014568 Vándor Andrea (VA, admin) Vándor Andrea true 10014568 true 2024-10-17T16:44:08.551+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Kovács, Orsolya Tünde true true /api/journal/10023324 REVIEWED FRONTIERS IN IMMUNOLOGY 1664-3224 1664-3224 true false 10023324 false 10023324 true 1664-3224 1664-3224 Journal FOREIGN 13 892970 892970 12 2022 Osteoclasts play a crucial role in the maintenance, repair, and remodeling of bones of the adult vertebral skeleton due to their bone resorption capability. Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are associated with increased activity of osteoclasts.</jats:p></jats:sec><jats:sec><jats:title>Objectives</jats:title><jats:p>Our study aimed to investigate the dynamic proteomic changes during osteoclast differentiation in healthy donors, in RA, and PsA.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Blood samples of healthy donors, RA, and PsA patients were collected, and monocytes were isolated and differentiated into osteoclasts <jats:italic>in vitro</jats:italic> using macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor κB ligand (RANK-L). Mass spectrometry-based proteomics was used to analyze proteins from cell lysates. The expression changes were analyzed with Gene Set Enrichment Analysis (GSEA).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The analysis of the proteomic changes revealed that during the differentiation of the human osteoclasts, expression of the proteins involved in metabolic activity, secretory function, and cell polarity is increased; by contrast, signaling pathways involved in the immune functions are downregulated. Interestingly, the differences between cells of healthy donors and RA/PsA patients are most pronounced after the final steps of differentiation to osteoclasts. In addition, both in RA and PsA the differentiation is characterized by decreased metabolic activity, associated with various immune pathway activities; furthermore by accelerated cytokine production in RA.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Our results shed light on the characteristic proteomic changes during human osteoclast differentiation and expression differences in RA and PsA, which reveal important pathophysiological insights in both diseases. Funding 2015933 /api/funding/2015933 (OTKA K131479) Támogató: OTKA false true Funding 2015934 /api/funding/2015934 (FK-138862) Támogató: OTKA false true Funding 2015935 /api/funding/2015935 ((NKFIH) [VEKOP-2.3.2-16-2016-00002) Támogató: NKFIH false true Funding 2015936 /api/funding/2015936 (TKP-76-8/PALY-2021) false true Funding 2015937 /api/funding/2015937 (TKP2021-EGA/TKP2021-NVA/ TKP2021-NKTA) false true true 2022 true true true false true false GOLD 2026-05-22 true https://doi.org/10.3389/fimmu.2022.892970 7 0 7 7 0 7 7 7 7 7 7 7 7 7 0 0 7 7 7 7 0 8 8 Folyóiratcikk Journal Article 24 7 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 1 1 1 1 2023 0 1 1 1 1 2024 0 1 1 1 1 2025 0 4 4 4 4 Q1 false 10046108 false false false 2022-07-16T15:53:31.001+0000 Biokémiai Tanszék (SE / AOK / I / BMBI); Enzimológiai Intézet (TTK); Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I); HCEMM-SE Extracelluláris Vezikula Kutatócsoport (SE / AOK / I / GSII); Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K); MTA-SE Immun-proteogenomikai Extracelluláris Ve... 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(2022) FRONTIERS IN IMMUNOLOGY 1664-3224 1664-3224 13<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10056868"><a href="/gui2/?type=authors&mode=browse&sel=10056868" target="_blank">Kovács Orsolya Tünde (<span class="authorship-author-name">Kovács Orsolya Tünde</span> <span class="authorAux-mtmt"> immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025667"><a href="/gui2/?type=authors&mode=browse&sel=10025667" target="_blank">Tóth Eszter^* (<span class="authorship-author-name">Tóth Eszter</span> <span class="authorAux-mtmt"> Proteomika</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014144"><a href="/gui2/?type=authors&mode=browse&sel=10014144" target="_blank">Ozohanics Olivér (<span class="authorship-author-name">Ozohanics Olivér</span> <span class="authorAux-mtmt"> Tömegspektrometria</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Biokémiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024241"><a href="/gui2/?type=authors&mode=browse&sel=10024241" target="_blank">Soltész-Katona Eszter (<span class="authorship-author-name">Soltész-Katona Eszter</span> <span class="authorAux-mtmt"> élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Élettani Intézet">ÉI</span>/MTA-SE Molekuláris Élettani Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10046108"><a href="/gui2/?type=authors&mode=browse&sel=10046108" target="_blank">Marton Nikolett (<span class="authorship-author-name">Marton Nikolett</span> <span class="authorAux-mtmt"> radiológia</span>) </a> </span> <span class="author-affil">Semmelweis Egyetem</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015596"><a href="/gui2/?type=authors&mode=browse&sel=10015596" target="_blank">Buzás Edit Irén (<span class="authorship-author-name">Buzás Edit Irén</span> <span class="authorAux-mtmt"> Immunbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Genetikai, Sejt- és Immunbiológiai Intézet">GSII</span>/MTA-SE Immun-proteogenomikai Extracelluláris Vezikula Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Genetikai, Sejt- és Immunbiológiai Intézet">GSII</span>/HCEMM-SE Extracelluláris Vezikula Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000772"><a href="/gui2/?type=authors&mode=browse&sel=10000772" target="_blank">Hunyady László (<span class="authorship-author-name">Hunyady László</span> <span class="authorAux-mtmt"> molekuláris élettan, kísérletes endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Élettani Intézet">ÉI</span>/MTA-SE Molekuláris Élettani Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002323"><a href="/gui2/?type=authors&mode=browse&sel=10002323" target="_blank">Drahos László (<span class="authorship-author-name">Drahos László</span> <span class="authorAux-mtmt"> proteomika, tömegspektrometria</span>) </a> </span> <span class="author-affil"><span title="MTA Természettudományi Kutatóközpont">MTA TTK</span>/Szerves Kémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015489"><a href="/gui2/?type=authors&mode=browse&sel=10015489" target="_blank">Turu Gábor^** ✉ (<span class="authorship-author-name">Turu Gábor</span> <span class="authorAux-mtmt"> Molekuláris Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Élettani Intézet">ÉI</span>/MTA-SE Molekuláris Élettani Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025749"><a href="/gui2/?type=authors&mode=browse&sel=10025749" target="_blank">Nagy György (<span class="authorship-author-name">Nagy György</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Belgyógyászati és Onkológiai Klinika">BOK</span>/Reumatológiai és Klinikai Immunológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32980571" target="_blank">Proteomic Changes of Osteoclast Differentiation in Rheumatoid and Psoriatic Arthritis Reveal Functional Differences</a></div> <div> <span class="journal-title">FRONTIERS IN IMMUNOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-3224">1664-3224</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-3224">1664-3224</a>)</span>: <span class="journal-volume">13</span> <span class="page"> Paper 892970. 12 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fimmu.2022.892970" target="_blank" href="https://doi.org/10.3389/fimmu.2022.892970"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000828084000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000828084000001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="163432" target="_blank" href="http://real.mtak.hu/163432"> REAL </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="9379" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/9379"> SE Repozitórium </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="114896" target="_blank" href="https://edit.elte.hu/xmlui/handle/10831/114896"> EDIT </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85134371939" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85134371939"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35860269" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35860269&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology and Allergy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 7</span> | Független: 7 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 7 | Scopus jelölt:&nbsp;7 | WoS/Scopus jelölt:&nbsp;7 | DOI jelölt:&nbsp;7 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32980571&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32980571</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (OTKA K131479) Támogató: OTKA, (FK-138862) Támogató: OTKA, (VEKOP-2.3.2-16-2016-00002) Támogató: NKFIH, (TKP-76-8/PALY-2021), (TKP2021-EGA/TKP2021-NVA/ TKP2021-NKTA) </div> <div class="lastModified">Utolsó módosítás: 2025.02.26. 00:23 Ladányi Gusztáv (MTMT API user, admin) </div> <div class="lockedBy">Központi kezelésű 2024.10.17. 18:44 Ladányi Gusztáv (MTMT API user, admin) Vándor Andrea (VA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary Department of Physiology, Semmelweis University, Budapest, Hungary Institute of Organic Chemistry, Eötvös Loránd Research Network, Research Centre for Natural Sciences, Budapest, Hungary Department of Biochemistry, Semmelweis Universit...</pre> </div></div>