https://m2.mtmt.hu/ hun 2026-10-25 00:04 JournalArticle 32927021 VALIDATED true Funding Agency and Grant Number: Hungarian research grants - National Research, Development, and Innovation Office [NKFI-124879, NKFI-124937]; National Laboratories Excellence Program (National Tumourbiology Laboratory project) [NLP17]; Hungarian Thematic Excellence Programme [TKP2021-EGA-44]; Horizon 2020 Framework Program [899995] Funding text: This work was supported by Hungarian research grants funded by the National Research, Development, and Innovation Office (grant number NKFI-124879 and NKFI-124937), the National Laboratories Excellence Program (under the National Tumourbiology Laboratory project (NLP17)) and the Hungarian Thematic Excellence Programme (TKP2021-EGA-44) and by Horizon 2020 Framework Program (grant agreement number: 899995, EURAMED rocc-n-roll). 0 false 2026-10-22T14:38:13.607+0000 2023-07-06T09:49:40.194+0000 2022-07-11T13:49:19.407+0000 true 10070075 Nádas Orsolya /api/admin/10070075 Admin true 2025-01-16T12:20:34.262+0000 2023-07-06T09:49:40.573+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10080105 /api/admin/10080105 Kériné Tornyi Katalin true true 2024-10-17T16:16:12.275+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Balázs, Katalin Prostate Cancer Survivors Present Long-Term, Residual Systemic Immune Alterations true true /api/journal/10032813 REVIEWED true false 10032813 false 10032813 true 2072-6694 Journal FOREIGN 14 13 3058 3058 24 2022 The development of cancer and anti-tumor therapies can lead to systemic immune alterations but little is known about how long immune dysfunction persists in cancer survivors.We followed changes in the cellular immune parameters of prostate cancer patients with good prognostic criteria treated with low dose rate brachytherapy before and up to 3 years after the initiation of therapy.Patients before therapy had a reduced CD4+ T cell pool and increased regulatory T cell fraction and these alterations persisted or got amplified during the 36-month follow-up. A significant decrease in the total NK cell number and a redistribution of the circulating NK cells in favor of a less functional anergic subpopulation was seen in patients before therapy but tumor regression led to the regeneration of the NK cell pool and functional integrity. The fraction of lymphoid DCs was increased in patients both before therapy and throughout the whole follow-up. Increased PDGF-AA, BB, CCL5 and CXCL5 levels were measured in patients before treatment but protein levels rapidly normalized.while NK cell dysfunction recovered, long-term, residual alterations persisted in the adaptive and partly in the innate immune system. Funding 2015881 /api/funding/2015881 false true Funding 2015882 /api/funding/2015882 false true Funding 2015883 /api/funding/2015883 false true Funding 2015884 /api/funding/2015884 false true Funding 2015885 /api/funding/2015885 false true true 2022 true true true false true false GOLD 2026-10-22 true https://doi.org/10.3390/cancers14133058 2 0 2 2 0 2 2 2 1 2 2 2 2 2 0 0 2 2 2 2 0 4 4 Folyóiratcikk Journal Article 24 2 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 1 1 1 1 2025 0 0 0 0 0 2026 0 1 1 1 1 Q1 false 10024626,10011699,10070077,10006020,10010426 false false false 2022-07-19T11:36:00.940+0000 Doktori Iskola (SE); Onkológiai Tanszék (SE / AOK / K); Országos Onkológiai Intézet 12 27 3 12 0 true 10080105 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 102330707 /api/authorship/102330707 1 0.083 true false false Author 10070077 /api/author/10070077 Balázs Katalin true true Balázs Katalin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102330708 /api/authorship/102330708 2 0.083 false false false Author 10020433 /api/author/10020433 Kocsis Zsuzsa true 10020433 true Kocsis Zsuzsa S true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102330709 /api/authorship/102330709 3 0.083 false false false Author 10030572 /api/author/10030572 Ágoston Péter Zoltán true 10030572 true Ágoston Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102330710 /api/authorship/102330710 4 0.083 false false false Author 10064469 /api/author/10064469 Jorgo Kliton true 10064469 true Jorgo Kliton true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102330711 /api/authorship/102330711 5 0.083 false false false Author 10058289 /api/author/10058289 Gesztesi László true 10058289 true Gesztesi László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102330712 /api/authorship/102330712 6 0.083 false false false Author 10011699 /api/author/10011699 Farkas Gyöngyi true 10011699 true Farkas Gyöngyi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102330713 /api/authorship/102330713 7 0.083 false false false Author 10032265 /api/author/10032265 Székely Gábor true 10032265 true Székely Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102330714 /api/authorship/102330714 8 0.083 false false false Author 10013883 /api/author/10013883 Takácsi-Nagy Zoltán true 10013883 true Takácsi-Nagy Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102330715 /api/authorship/102330715 9 0.083 false false false Author 10013383 /api/author/10013383 Polgár Csaba true 10013383 true Polgár Csaba true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102330716 /api/authorship/102330716 10 0.083 false false false Author 10006020 /api/author/10006020 Sáfrány Géza true 10006020 true Sáfrány Géza true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102330717 /api/authorship/102330717 11 0.083 false false false Author 10010426 /api/author/10010426 Jurányi Zsolt true 10010426 true Jurányi Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102330718 /api/authorship/102330718 12 0.083 false true true Author 10024626 /api/author/10024626 Lumniczky Katalin true 10024626 true Lumniczky Katalin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 21261454 /api/publicationidentifier/21261454 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/cancers14133058 https://doi.org/10.3390/cancers14133058 false true PublicationIdentifier 21463343 /api/publicationidentifier/21463343 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 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19309 /api/keyword/19309 true 19309 true Keyword 1030129 /api/keyword/1030129 true 1030129 true Keyword 1504129 /api/keyword/1504129 true true Keyword 1517750 /api/keyword/1517750 true true Keyword 1790421 /api/keyword/1790421 true true SjrRating 11315334 /api/sjrrating/11315334 81 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2730 /api/classificationexternal/2730 true 2730 true Q1 DIRECT true true /api/publication/32927021 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10070077"><a href="/gui2/?type=authors&mode=browse&sel=10070077" target="_blank">Balázs Katalin (<span class="authorship-author-name">Balázs Katalin</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020433"><a href="/gui2/?type=authors&mode=browse&sel=10020433" target="_blank">Kocsis Zsuzsa S (<span class="authorship-author-name">Kocsis Zsuzsa</span> <span class="authorAux-mtmt"> sugárbiológia, onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10030572"><a href="/gui2/?type=authors&mode=browse&sel=10030572" target="_blank">Ágoston Péter (<span class="authorship-author-name">Ágoston Péter Zoltán</span> <span class="authorAux-mtmt"> Sugárterápia, onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064469"><a href="/gui2/?type=authors&mode=browse&sel=10064469" target="_blank">Jorgo Kliton (<span class="authorship-author-name">Jorgo Kliton</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10058289"><a href="/gui2/?type=authors&mode=browse&sel=10058289" target="_blank">Gesztesi László (<span class="authorship-author-name">Gesztesi László</span> <span class="authorAux-mtmt"> Sugárterápia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011699"><a href="/gui2/?type=authors&mode=browse&sel=10011699" target="_blank">Farkas Gyöngyi (<span class="authorship-author-name">Farkas Gyöngyi</span> <span class="authorAux-mtmt"> Környezeti mikrobiológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032265"><a href="/gui2/?type=authors&mode=browse&sel=10032265" target="_blank">Székely Gábor (<span class="authorship-author-name">Székely Gábor</span> <span class="authorAux-mtmt"> genetika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013883"><a href="/gui2/?type=authors&mode=browse&sel=10013883" target="_blank">Takácsi-Nagy Zoltán (<span class="authorship-author-name">Takácsi-Nagy Zoltán</span> <span class="authorAux-mtmt"> Sugárterápia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013383"><a href="/gui2/?type=authors&mode=browse&sel=10013383" target="_blank">Polgár Csaba (<span class="authorship-author-name">Polgár Csaba</span> <span class="authorAux-mtmt"> Sugárterápia, klinikai onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10006020"><a href="/gui2/?type=authors&mode=browse&sel=10006020" target="_blank">Sáfrány Géza (<span class="authorship-author-name">Sáfrány Géza</span> <span class="authorAux-mtmt"> sugárbiológia, génterápia, sugáregészségügy, su...</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010426"><a href="/gui2/?type=authors&mode=browse&sel=10010426" target="_blank">Jurányi Zsolt (<span class="authorship-author-name">Jurányi Zsolt</span> <span class="authorAux-mtmt"> Onkológiai kutatás, sugárterápia, sugárbiológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024626"><a href="/gui2/?type=authors&mode=browse&sel=10024626" target="_blank">Lumniczky Katalin ✉ (<span class="authorship-author-name">Lumniczky Katalin</span> <span class="authorAux-mtmt"> Sugárbiológia</span>) </a> </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32927021" target="_blank">Prostate Cancer Survivors Present Long-Term, Residual Systemic Immune Alterations</a></div> <div> <span class="journal-title">CANCERS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2072-6694">2072-6694</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">13</span> <span class="page"> Paper 3058. 24 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/cancers14133058" target="_blank" href="https://doi.org/10.3390/cancers14133058"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000822143800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000822143800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85132971520" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85132971520"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35804830" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35804830&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 2</span> | Független: 2 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 2 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;2 | DOI jelölt:&nbsp;2 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32927021&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32927021</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (NKFI-124879), (NKFI-124937), National Laboratories Excellence program (under the National Tumor Biology Laboratory Project(NLP-17), Hungarian Thematic Excellence Program((TKP2021-EGA-44)), (Horizon 2020 Framework Program (grant agreement number: 899995) </div> <div class="lastModified">Utolsó módosítás: 2023.07.06. 11:49 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> <div class="lockedBy">Központi kezelésű 2024.10.17. 18:16 Ladányi Gusztáv (MTMT API user, admin) Kériné Tornyi Katalin (MTMT ellenőrzés admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Hungarian research grants - National Research, Development, and Innovation Office [NKFI-124879, NKFI-124937]; National Laboratories Excellence Program (National Tumourbiology Laboratory project) [NLP17]; Hungarian Thematic Excellence Programme [TKP2021-EGA-44]; Horizon 2020 Framework Program [899995] Funding text: This work was supported by Hungarian...</pre> </div></div>