Integrált kutatói utánpótlás-képzési program az informatika és számítástudomány diszciplináris
te...(EFOP-3.6.3-VEKOP-16-2017-00002) Támogató: EFOP-VEKOP
BACKGROUND Urodynamics can detect subtle voiding changes before cystopathy symptoms
manifest. The aim of the present study was to assess urodynamic changes in diabetic
women. MATERIAL AND METHODS A systematic search was performed on 04 November 2021
to identify studies reporting urodynamic parameters in diabetic women. Data were analyzed
in a single-arm meta-analysis due to lack of sufficient studies with direct comparisons
to healthy women. For data synthesis, a random-effects model with restricted maximum-likelihood
estimation was applied. The calculated effect sizes were visualized in forest plots.
Statistical heterogeneity was assessed using the I² measure and the χ² test. The risk
of bias was assessed using the QUIPS tool. PROSPERO ID: CRD42021256275. RESULTS Out
of 1750 records, 10 studies were used in the analysis (n=2342 diabetic women). Pooled
event rates showed that mean voided volume was 288.21 mL [95% confidence interval
(CI): 217.35-359.06, I²=98%], mean postvoid residual volume was 93.67 mL [95% CI:
31.35-155.99, I²=100%], mean Qmax was 18.80 mL/sec [95% CI: 15.27-22.33, I²=99%],
mean PdetQmax is 30.13 cmH2O [95% CI: 25.53-34.73, I²=90%], mean first sensation of
bladder filling was 178.66 mL [95% CI: 150.59-206.72, I²=97%], and mean cystometric
capacity was 480.41 mL [95% CI: 409.32-551.50, I²=98%] in diabetic women. CONCLUSIONS
Pooled results indicate that diabetic women tend to have a smaller voided volume,
slower Qmax and PdetQmax, larger postvoid residual, and higher first sensation of
bladder filling and cystometric capacity compared to the general female population.
