https://m2.mtmt.hu/ eng 2026-10-25 17:01 JournalArticle 32911176 VALIDATED true EID: 2-s2.0-85133420878 Export Date: 14 September 2026; Cited By: 10; Correspondence Address: A.A. Horvath; Neurocognitive Research Center, National Institute of Mental Health, Neurology and Neurosurgery, Budapest, Hungary; email: horvath.andras1@med.semmelweis-univ.hu 0 false 2026-10-22T13:45:47.340+0000 2026-09-14T10:48:55.177+0000 2022-06-29T05:26:52.667+0000 true 10078148 Havas Petra /api/admin/10078148 Admin true 2026-09-14T10:57:23.985+0000 2024-12-06T18:01:38.763+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Berente, Dalida Borbala Alteration of Visuospatial System as an Early Marker of Cognitive Decline A Double-Center Neuroimaging Study true true /api/journal/10023304 REVIEWED true false 10023304 false 10023304 true 1663-4365 1663-4365 Journal FOREIGN 14 854368 854368 14 2022 Amnestic-type mild cognitive impairment (a-MCI) represents the prodromal phase of Alzheimer's disease associated with a high conversion rate to dementia and serves as a potential golden period for interventions. In our study, we analyzed the role of visuospatial (VS) functions and networks in the recognition of a-MCI. We examined 78 participants (32 patients and 46 controls) in a double-center arrangement using neuropsychology, structural, and resting-state functional MRI. We found that imaging of the lateral temporal areas showed strong discriminating power since in patients only the temporal pole (F = 5.26, p = 0.034) and superior temporal gyrus (F = 8.04, p < 0.001) showed reduced cortical thickness. We demonstrated significant differences between controls and patients in various neuropsychological results; however, analysis of cognitive subdomains revealed that the largest difference was presented in VS skills (F = 8.32, p < 0.001). Functional connectivity analysis of VS network showed that patients had weaker connectivity between the left and right frontotemporal areas, while stronger local connectivity was presented between the left frontotemporal structures (FWE corrected p < 0.05). Our results highlight the remarkable potential of examining the VS system in the early detection of cognitive decline. Since resting-state setting of functional MRI simplifies the possible automatization of data analysis, detection of VS system alterations might provide a non-invasive biomarker of a-MCI. Funding 2015977 /api/funding/2015977 false true Funding 2015978 /api/funding/2015978 false true Funding 2015979 /api/funding/2015979 false true Funding 2015980 /api/funding/2015980 false true Funding 2015981 /api/funding/2015981 false true Funding 2015982 /api/funding/2015982 false true true 2022 true true true false true false GOLD 2026-10-22 true https://doi.org/10.3389/fnagi.2022.854368 16 0 13 10 3 13 13 12 12 12 12 9 9 13 3 0 16 13 13 10 0 1 1 Folyóiratcikk Journal Article 24 13 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 3 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 1 1 1 2024 0 2 2 2 2 2025 0 5 4 5 4 2026 0 8 6 8 6 Q2 false 10084272 false false false 2022-07-18T08:38:43.895+0000 Amerikai úti Ideggyógyászati és Idegsebészeti I... (OMIII); Anatómiai, Szövet- és Fejlődéstani Intézet (SE / AOK / I); Családorvosi Tanszék (SE / AOK / K); Doktori Iskola (SE); Neurológiai Klinika (SE / AOK / K); Országos Mentális, Ideggyógyászati és Idegsebés...; Pszichiátriai és Pszichoterápiás Klinika (SE / AOK / K); Általános Orvostudományi Kar (SE) 6 29 8 8 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 102226159 /api/authorship/102226159 1 0.125 true false false Author 10083416 /api/author/10083416 Berente Dalida Borbála true true Berente Dalida Borbala true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102226160 /api/authorship/102226160 2 0.125 false false false Author 10084272 /api/author/10084272 Zsuffa János true true Zsuffa Janos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102226161 /api/authorship/102226161 3 0.125 false false false Author 10084295 /api/author/10084295 Werber Tom true true Werber Tom true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102226162 /api/authorship/102226162 4 0.125 false false false Kiss Mate true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102226163 /api/authorship/102226163 5 0.125 false false false Drotos Anita true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102226164 /api/authorship/102226164 6 0.125 false false false Author 10000108 /api/author/10000108 Kamondi Anita true 10000108 true Kamondi Anita true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102226165 /api/authorship/102226165 7 0.125 false false false Author 10023954 /api/author/10023954 Csukly Gábor true 10023954 true Csukly Gabor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102226166 /api/authorship/102226166 8 0.125 false true true Author 10055054 /api/author/10055054 Horváth András Attila true 10055054 true Horvath Andras Attila true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 21222731 /api/publicationidentifier/21222731 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3389/fnagi.2022.854368 https://doi.org/10.3389/fnagi.2022.854368 false true PublicationIdentifier 21427172 /api/publicationidentifier/21427172 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000815771900001 https://www.webofscience.com/wos/woscc/full-record/000815771900001 true true PublicationIdentifier 21427177 /api/publicationidentifier/21427177 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85133420878 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85133420878 true true PublicationIdentifier 21222730 /api/publicationidentifier/21222730 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 35754966 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35754966&dopt=Abstract false true Classification 12181 /api/classification/12181 true true Keyword 17772 /api/keyword/17772 true 17772 true Keyword 1084437 /api/keyword/1084437 true 1084437 true Keyword 1615794 /api/keyword/1615794 true true Keyword 1752790 /api/keyword/1752790 true true Keyword 1823207 /api/keyword/1823207 true true Keyword 1986690 /api/keyword/1986690 true true SjrRating 11282972 /api/sjrrating/11282972 15 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1302 /api/classificationexternal/1302 true 1302 true Q2 DIRECT true true /api/publication/32911176 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10083416"><a href="/gui2/?type=authors&mode=browse&sel=10083416" target="_blank">Berente Dalida Borbala (<span class="authorship-author-name">Berente Dalida Borbála</span> <span class="authorAux-mtmt"> Orvosi tudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10084272"><a href="/gui2/?type=authors&mode=browse&sel=10084272" target="_blank">Zsuffa Janos (<span class="authorship-author-name">Zsuffa János</span> <span class="authorAux-mtmt"> Háziorvostan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Family Medicine; Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10084295"><a href="/gui2/?type=authors&mode=browse&sel=10084295" target="_blank">Werber Tom (<span class="authorship-author-name">Werber Tom</span> <span class="authorAux-mtmt"> Medicine</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/Faculty of Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kiss Mate </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Drotos Anita </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000108"><a href="/gui2/?type=authors&mode=browse&sel=10000108" target="_blank">Kamondi Anita (<span class="authorship-author-name">Kamondi Anita</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Neurology; Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet; <span title="Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet">OMIII</span>/Institute of Neurology and Neurosurgery (Amerikai street)</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023954"><a href="/gui2/?type=authors&mode=browse&sel=10023954" target="_blank">Csukly Gabor (<span class="authorship-author-name">Csukly Gábor</span> <span class="authorAux-mtmt"> Pszichiátria</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Pszichiátriai és Pszichoterápiás Klinika; Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055054"><a href="/gui2/?type=authors&mode=browse&sel=10055054" target="_blank">Horvath Andras Attila ✉ (<span class="authorship-author-name">Horváth András Attila</span> <span class="authorAux-mtmt"> neurológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet; Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32911176" target="_blank">Alteration of Visuospatial System as an Early Marker of Cognitive Decline : A Double-Center Neuroimaging Study.</a></div> <div> <span class="journal-title">FRONTIERS IN AGING NEUROSCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1663-4365">1663-4365</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1663-4365">1663-4365</a>)</span>: <span class="journal-volume">14</span> <span class="page"> Paper 854368. 14 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fnagi.2022.854368" target="_blank" href="https://doi.org/10.3389/fnagi.2022.854368"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000815771900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000815771900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85133420878" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85133420878"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35754966" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35754966&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Aging&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Cognitive Neuroscience&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 16</span> | Independent citation: 13 | Self citation: 3 | Unknown citation: 0 | Number of citations in WoS: 12 | Number of citations in Scopus:&nbsp;12 | WoS/Scopus assigned:&nbsp;12 | Number of citations with DOI:&nbsp;13 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32911176&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32911176</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Agykutatási Kiválósági Központok fejlesztése(KTIA_NAP_13-1-2013-0001) Funder: NRDIO, Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002), (PD-132652) Funder: NKFI, (bo_78_20_2020) Funder: Bolyai János Kutatási Ösztöndíj, Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Funder: EFOP-VEKOP, (2019-2.1.7-ERA-NET-2020-00006) Funder: NKFI </div> <div class="lastModified">Last Modified: 2026.09.14. 12:48 Zóra Kondor (SE_KK_Admin5_KZ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: EID: 2-s2.0-85133420878 Export Date: 14 September 2026; Cited By: 10; Correspondence Address: A.A. Horvath; Neurocognitive Research Center, National Institute of Mental Health, Neurology and Neurosurgery, Budapest, Hungary; email: horvath.andras1@med.semmelweis-univ.hu</pre> </div></div>