https://m2.mtmt.hu/ hun 2026-09-20 17:41 JournalArticle 32907494 VALIDATED true Department of Pharmacognosy, Faculty of Pharmacy, University of Pecs, Pecs, H-7624, Hungary Department of Pharmacology and Pharmacotherapy, Medical School, University of Pecs, Pecs, H-7624, Hungary Szentágothai Research Centre, University of Pecs, Pecs, H-7624, Hungary Department of Medical Biology and Central Electron Microscope Laboratory, Medical School, University of Pecs, Pecs, H-7624, Hungary Department of Pathology, Medical School, University of Pecs, Pecs, H-7624, Hungary Department of Medical Microbiology and Immunology, Medical School, University of Pecs, Pecs, H-7624, Hungary Institute of Pharmacognosy, Faculty of Pharmacy, Semmelweis University, Budapest, H-1085, Hungary PharmInVivo Ltd, Pecs, H-7629, Hungary Cited By :2 Export Date: 4 September 2023 CODEN: MOLEF Correspondence Address: Horváth, G.; Department of Pharmacognosy, Hungary; email: horvath.gyorgyi@gytk.pte.hu 0 false 2026-08-23T14:17:00.948+0000 2026-01-29T08:49:07.392+0000 2022-06-27T08:55:26.979+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-08-17T08:04:14.609+0000 2023-09-02T13:58:46.914+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10097590 /api/admin/10097590 Orbán Zsófia true true 2024-10-17T16:10:53.532+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Csikós, Eszter Pinus sylvestris L. and Syzygium aromaticum (L.) Merr. & L. M. Perry Essential Oils Inhibit Endotoxin-Induced Airway Hyperreactivity despite Aggravated Inflammatory Mechanisms in Mice. true true /api/journal/25013 REVIEWED true false 25013 false 25013 true 1431-5157 1420-3049 Journal FOREIGN 27 12 3868 3868 14 2022 Scots pine (SO) and clove (CO) essential oils (EOs) are commonly used by inhalation, and their main components are shown to reduce inflammatory mediator production. The aim of our research was to investigate the chemical composition of commercially available SO and CO by gas chromatography-mass spectrometry and study their effects on airway functions and inflammation in an acute pneumonitis mouse model. Inflammation was evoked by intratracheal endotoxin and EOs were inhaled three times during the 24 h experimental period. Respiratory function was analyzed by unrestrained whole-body plethysmography, lung inflammation by semiquantitative histopathological scoring, myeloperoxidase (MPO) activity and cytokine measurements. α-Pinene (39.4%) was the main component in SO, and eugenol (88.6%) in CO. Both SO and CO significantly reduced airway hyperresponsiveness, and prevented peak expiratory flow, tidal volume increases and perivascular edema formation. Meanwhile, inflammatory cell infiltration was not remarkably affected. In contrast, MPO activity and several inflammatory cytokines (IL-1β, KC, MCP-1, MIP-2, TNF-α) were aggravated by both EOs. This is the first evidence that SO and CO inhalation improve airway function, but enhance certain inflammatory parameters. These results suggest that these EOs should be used with caution in cases of inflammation-associated respiratory diseases. Funding 2016070 /api/funding/2016070 false true Funding 2016071 /api/funding/2016071 false true Funding 2016072 /api/funding/2016072 false true true 2022 true true true false true false GOLD 2026-08-23 true https://doi.org/10.3390/molecules27123868 10 0 10 9 1 10 10 7 10 10 10 9 9 9 1 0 10 9 10 9 0 6 6 Folyóiratcikk Journal Article 24 10 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 2 2 2 2 2024 0 2 2 2 2 2025 0 4 3 4 3 2026 0 2 2 2 2 Q1 false 10060723,10020673,10039772 false false false 2022-06-26T09:24:26.079+0000 Farmakognóziai Intézet (PTE / GYTK); Farmakognóziai Intézet (SE / GYTK); Farmakológiai és Farmakoterápiai Intézet (PTE / ÁOK); Molekuláris farmakológia kutatócsoport (PTE / SZKK); Orvosi Biológiai Intézet és Központi Elektronmi... 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8 0.11111111 false false false Author 10001426 /api/author/10001426 Helyes Zsuzsanna true 10001426 true Helyes Zsuzsanna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 102207624 /api/authorship/102207624 9 0.111 false true true Author 10016483 /api/author/10016483 Horváth Györgyi true 10016483 true Horváth Györgyi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 21212570 /api/publicationidentifier/21212570 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/molecules27123868 https://doi.org/10.3390/molecules27123868 false true PublicationIdentifier 21251913 /api/publicationidentifier/21251913 SwordSource 84 /api/publicationsource/84 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true SE Repozitórium SE Repozitórium 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true Keyword 1012159 /api/keyword/1012159 true 1012159 true Keyword 1014768 /api/keyword/1014768 true 1014768 true Keyword 1063248 /api/keyword/1063248 true 1063248 true Keyword 1596575 /api/keyword/1596575 true true Keyword 2030019 /api/keyword/2030019 true true SjrRating 11321239 /api/sjrrating/11321239 44 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3003 /api/classificationexternal/3003 true 3003 true Q1 DIRECT true true /api/publication/32907494 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10060723"><a href="/gui2/?type=authors&mode=browse&sel=10060723" target="_blank">Csikós Eszter (<span class="authorship-author-name">Csikós Eszter</span> <span class="authorAux-mtmt"> Gyógyszerészet</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Farmakognóziai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10039772"><a href="/gui2/?type=authors&mode=browse&sel=10039772" target="_blank">Csekő Kata (<span class="authorship-author-name">Csekő Kata</span> <span class="authorAux-mtmt"> Gyógyszertudományok</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Farmakológiai és Farmakoterápiai Intézet; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Szentágothai János Kutatóközpont">SZKK</span>/Molekuláris farmakológia kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018850"><a href="/gui2/?type=authors&mode=browse&sel=10018850" target="_blank">Kemény Ágnes (<span class="authorship-author-name">Kemény Ágnes</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Farmakológiai és Farmakoterápiai Intézet; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Szentágothai János Kutatóközpont">SZKK</span>/Molekuláris farmakológia kutatócsoport; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Biológiai Intézet és Központi Elektronmikroszkópos Laboratórium</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10090890"><a href="/gui2/?type=authors&mode=browse&sel=10090890" target="_blank">Draskóczi Lilla (<span class="authorship-author-name">Draskóczi Lilla Gréta</span> <span class="authorAux-mtmt"> Daganatos megbetegedések molekuláris hátterének...</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020673"><a href="/gui2/?type=authors&mode=browse&sel=10020673" target="_blank">Kereskai László (<span class="authorship-author-name">Kereskai László</span> <span class="authorAux-mtmt"> Pathológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Pathologiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10005896"><a href="/gui2/?type=authors&mode=browse&sel=10005896" target="_blank">Kocsis Béla (<span class="authorship-author-name">Kocsis Béla</span> <span class="authorAux-mtmt"> Orvosi mikrobiológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Mikrobiológiai és Immunitástani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032429"><a href="/gui2/?type=authors&mode=browse&sel=10032429" target="_blank">Böszörményi Andrea (<span class="authorship-author-name">Böszörményi Andrea</span> <span class="authorAux-mtmt"> gázkromatográfia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Farmakognóziai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001426"><a href="/gui2/?type=authors&mode=browse&sel=10001426" target="_blank">Helyes Zsuzsanna (<span class="authorship-author-name">Helyes Zsuzsanna</span> <span class="authorAux-mtmt"> Neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Farmakológiai és Farmakoterápiai Intézet; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Szentágothai János Kutatóközpont">SZKK</span>/Molekuláris farmakológia kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10016483"><a href="/gui2/?type=authors&mode=browse&sel=10016483" target="_blank">Horváth Györgyi ✉ (<span class="authorship-author-name">Horváth Györgyi</span> <span class="authorAux-mtmt"> Gyógyszerészet</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Farmakognóziai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32907494" target="_blank">Pinus sylvestris L. and Syzygium aromaticum (L.) Merr. & L. M. Perry Essential Oils Inhibit Endotoxin-Induced Airway Hyperreactivity despite Aggravated Inflammatory Mechanisms in Mice.</a></div> <div> <span class="journal-title">MOLECULES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1431-5157">1431-5157</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1420-3049">1420-3049</a>)</span>: <span class="journal-volume">27</span> <span class="journal-issue">12</span> <span class="page"> Paper 3868. 14 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/molecules27123868" target="_blank" href="https://doi.org/10.3390/molecules27123868"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="9212" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/9212"> SE Repozitórium </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000817365800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000817365800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85132591365" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85132591365"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35744988" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35744988&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://www.mdpi.com/1420-3049/27/12/3868" target="_blank" href="https://www.mdpi.com/1420-3049/27/12/3868"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmaceutical Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Analytical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Chemistry (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Drug Discovery&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 10</span> | Független: 9 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 7 | Scopus jelölt:&nbsp;10 | WoS/Scopus jelölt:&nbsp;10 | DOI jelölt:&nbsp;10 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32907494&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32907494</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> Innovációs és Technológiai Minisztérium(ÚNKP-20-3-II), (TKP2021-EGA-13), Thematic Excellence Program 2021 Health Sub-program of the Ministry for Innovation and Technology...(TKP2021-EGA-16) </div> <div class="lastModified">Utolsó módosítás: 2026.01.29. 09:49 Draskóczi Lilla Gréta (Daganatos megbetegedések molekuláris hátterének vizsgálata) </div> <div class="lockedBy">Központi kezelésű 2024.10.17. 18:10 Ladányi Gusztáv (MTMT API user, admin) Orbán Zsófia (MTMT ellenőrzés, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Pharmacognosy, Faculty of Pharmacy, University of Pecs, Pecs, H-7624, Hungary Department of Pharmacology and Pharmacotherapy, Medical School, University of Pecs, Pecs, H-7624, Hungary Szentágothai Research Centre, University of Pecs, Pecs, H-7624, Hungary Department of Medical Biology and Central Electron Micr...</pre> </div></div>