https://m2.mtmt.hu/ hun 2026-09-22 16:55 JournalArticle 32869216 VALIDATED true Cited By :4 Export Date: 14 December 2023 Chemicals/CAS: creatinine, 19230-81-0, 60-27-5; glucose, 50-99-7, 84778-64-3; hemoglobin, 9008-02-0; lipid, 66455-18-3; deoxyguanosine, 961-07-9; Biomarkers; Deoxyguanosine 0 false 2026-08-27T12:15:49.415+0000 2023-12-06T22:13:26.230+0000 2022-06-09T07:53:05.060+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-08-27T12:14:26.562+0000 2023-12-06T22:13:26.470+0000 true 10065569 Pécsi Éva /api/admin/10065569 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Mukli, Peter Urinary Biomarkers of Oxidative Stress in Aging: Implications for Prediction of Accelerated Biological Age in Prospective Cohort Studies true true /api/journal/10011773 REVIEWED true false 10011773 false 10011773 true 1942-0900 1942-0994 Journal FOREIGN 2022 6110226 6110226 12 2022 Background. Aging is a major risk factor for a range of chronic diseases. Oxidative stress theory of aging has been previously proposed as one of the mechanisms responsible for the age-related decline in organ/tissue function and the development of age-related diseases. Urine contains rich biological information on the health status of every major organ system and can be an important noninvasive source for biomarkers of systemic oxidative stress in aging. Aims. The objective of this cross-sectional study was to validate a novel panel of urinary oxidative stress biomarkers. Methods. Nucleic acid oxidation adducts and oxidative damage markers of lipids and proteins were assessed in urine samples from nondiabetic and currently nonsmoking subjects (n=198) across different ages (20 to 89 years old). Urinary parameters and chronological age were correlated then the biological age of enrolled individuals was determined from the urinary oxidative stress markers using the algorithm of Klemera and Doubal. Results. Our findings showed that 8-oxo-7,8-deoxyguanosine (8-oxoG), 8-oxo-7,8-dihydroguanosine (8-OHdG), and dityrosine (DTyr) positively correlated with chronological age, while the level of an F-2-isoprostane (iPF(2)alpha-VI) correlated negatively with age. We found that 8-oxoG, DTyr, and iPF(2)alpha-VI were significantly higher among accelerated agers compared to nonaccelerated agers and that a decision tree model could successfully identify accelerated agers with an accuracy of > 92%. Discussion. Our results indicate that 8-oxoG and iPF(2)alpha-VI levels in the urine reveal biological aging. Conclusion. Assessing urinary biomarkers of oxidative stress may be an important approach for the evaluation of biological age by identifying individuals at accelerated risk for the development of age-related diseases. true true 2022 true true true false true false GOLD 2026-08-27 true https://doi.org/10.1155/2022/6110226 11 0 11 10 1 11 11 8 11 11 11 10 10 10 1 0 11 10 11 10 0 13 13 Folyóiratcikk Journal Article 24 11 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 3 2 3 2 2024 0 4 4 4 4 2025 0 1 1 1 1 2026 0 3 3 3 3 Q1 false false false false 2022-06-08T08:02:17.743+0000 Belgyógyászati és Onkológiai Klinika (SE / AOK / K); Doktori Iskola (SE); Népegészségtani Intézet (SE / AOK / I); Transzlációs Medicina Intézet (SE / AOK / I); Élettani Intézet (SE / AOK / I) 7 46 5 12 0 false Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 101963450 /api/authorship/101963450 1 0.083 true false false Author 10032249 /api/author/10032249 Mukli Péter true 10032249 true Mukli Peter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101963451 /api/authorship/101963451 2 0.083333336 false false false Wu Dee H. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101963452 /api/authorship/101963452 3 0.083 false false false Author 10055259 /api/author/10055259 Csípő Tamás true 10055259 true Csipo Tamas true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101963453 /api/authorship/101963453 4 0.083333336 false false false Owens Cameron D. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101963454 /api/authorship/101963454 5 0.083 false false false Author 10075114 /api/author/10075114 Lipécz Ágnes true true Lipecz Agnes true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101963455 /api/authorship/101963455 6 0.083 false false false Author 10059431 /api/author/10059431 Rácz Frigyes Sámuel true 10059431 true Racz Frigyes Samuel true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101963456 /api/authorship/101963456 7 0.083333336 false false false Zouein Fouad A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101963457 /api/authorship/101963457 8 0.083 false false false Author 10024030 /api/author/10024030 Tabák Ádám true 10024030 true Tabak Adam true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101963458 /api/authorship/101963458 9 0.083 false false false Author 10071157 /api/author/10071157 Csiszar Anna true true Csiszar Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101963459 /api/authorship/101963459 10 0.083 false false false Author 10043602 /api/author/10043602 Ungvári Zoltán István true 10043602 true Ungvari Zoltan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101963460 /api/authorship/101963460 11 0.083333336 false false false Tsitouras Panayiotis D. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101963461 /api/authorship/101963461 12 0.083333336 false true true Yabluchanskiy Andriy true 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true true /api/publication/32869216 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10032249"><a href="/gui2/?type=authors&mode=browse&sel=10032249" target="_blank">Mukli Peter (<span class="authorship-author-name">Mukli Péter</span> <span class="authorAux-mtmt"> Élettan, megelőző orvostan és népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wu Dee H. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055259"><a href="/gui2/?type=authors&mode=browse&sel=10055259" target="_blank">Csipo Tamas (<span class="authorship-author-name">Csípő Tamás</span> <span class="authorAux-mtmt"> kardiológia, vaszkuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Owens Cameron D. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075114"><a href="/gui2/?type=authors&mode=browse&sel=10075114" target="_blank">Lipecz Agnes (<span class="authorship-author-name">Lipécz Ágnes</span> <span class="authorAux-mtmt"> orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10059431"><a href="/gui2/?type=authors&mode=browse&sel=10059431" target="_blank">Racz Frigyes Samuel (<span class="authorship-author-name">Rácz Frigyes Sámuel</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zouein Fouad A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024030"><a href="/gui2/?type=authors&mode=browse&sel=10024030" target="_blank">Tabak Adam (<span class="authorship-author-name">Tabák Ádám</span> <span class="authorAux-mtmt"> belgyógyászat, diabetológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071157"><a href="/gui2/?type=authors&mode=browse&sel=10071157" target="_blank">Csiszar Anna (<span class="authorship-author-name">Csiszar Anna</span> <span class="authorAux-mtmt"> Orvostudomany</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvari Zoltan (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, megelőző orvostan, népegészségta...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tsitouras Panayiotis D. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yabluchanskiy Andriy ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32869216" target="_blank">Urinary Biomarkers of Oxidative Stress in Aging: Implications for Prediction of Accelerated Biological Age in Prospective Cohort Studies</a></div> <div> <span class="journal-title">OXIDATIVE MEDICINE AND CELLULAR LONGEVITY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1942-0900">1942-0900</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1942-0994">1942-0994</a>)</span>: <span class="journal-volume">2022</span> <span class="page"> Paper 6110226. 12 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1155/2022/6110226" target="_blank" href="https://doi.org/10.1155/2022/6110226"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000797685300005" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000797685300005"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85130052037" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85130052037"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35571254" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35571254&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Aging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 11</span> | Független: 10 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 8 | Scopus jelölt:&nbsp;11 | WoS/Scopus jelölt:&nbsp;11 | DOI jelölt:&nbsp;11 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32869216&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 13 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32869216</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2023.12.06. 23:13 Pécsi Éva (MTMT Közp 2,3, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Cited By :4 Export Date: 14 December 2023 Chemicals/CAS: creatinine, 19230-81-0, 60-27-5; glucose, 50-99-7, 84778-64-3; hemoglobin, 9008-02-0; lipid, 66455-18-3; deoxyguanosine, 961-07-9; Biomarkers; Deoxyguanosine</pre> </div></div>