https://m2.mtmt.hu/ hun 2026-09-23 07:47 JournalArticle 32869047 VALIDATED true Funding Agency and Grant Number: Semmelweis University; National Research, Development and Innovation Office, Hungary [2020-1.1.2-PIACI-KFI-2021-00298]; Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary, of the Semmelweis University Funding text: Open access funding provided by Semmelweis University. This research was funded by the National Research, Development and Innovation Office, Hungary (grant number 2020-1.1.2-PIACI-KFI-2021-00298). The study was also financed by the Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary, within the framework of the molecular biology thematic program of the Semmelweis University. 0 false 2026-09-16T12:01:22.698+0000 2023-01-12T07:43:36.234+0000 2022-06-09T03:46:25.653+0000 true 10082843 Berhidi Anna /api/admin/10082843 Admin true 2026-07-19T10:09:32.935+0000 2026-07-19T10:09:32.935+0000 2022-11-03T13:37:26.750+0000 true 10071338 Molnár-Taga Márta /api/admin/10071338 Admin true 2023-01-12T07:43:36.655+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Szigeti, Krisztina A Global DNA hypomethylation of colorectal tumours detected in tissue and liquid biopsies may be related to decreased methyl-donor content true true /api/journal/10000700 REVIEWED true false 10000700 false 10000700 true 1471-2407 1471-2407 Journal FOREIGN 22 1 605 605 11 2022 Hypomethylation of long interspersed nuclear element 1 (LINE-1) is characteristic of various cancer types, including colorectal cancer (CRC). Malfunction of several factors or alteration of methyl-donor molecules' (folic acid and S-adenosylmethionine) availability can contribute to DNA methylation changes. Detection of epigenetic alterations in liquid biopsies can assist in the early recognition of CRC. Following the investigations of a Hungarian colon tissue sample set, our goal was to examine the LINE-1 methylation of blood samples along the colorectal adenoma-carcinoma sequence and in inflammatory bowel disease. Moreover, we aimed to explore the possible underlying mechanisms of global DNA hypomethylation formation on a multi-level aspect.LINE-1 methylation of colon tissue (n = 183) and plasma (n = 48) samples of healthy controls and patients with colorectal tumours were examined with bisulfite pyrosequencing. To investigate mRNA expression, microarray analysis results were reanalysed in silico (n = 60). Immunohistochemistry staining was used to validate DNA methyltransferases (DNMTs) and folate receptor beta (FOLR2) expression along with the determination of methyl-donor molecules' in situ level (n = 40).Significantly decreased LINE-1 methylation level was observed in line with cancer progression both in tissue (adenoma: 72.7 ± 4.8%, and CRC: 69.7 ± 7.6% vs. normal: 77.5 ± 1.7%, p ≤ 0.01) and liquid biopsies (adenoma: 80.0 ± 1.7%, and CRC: 79.8 ± 1.3% vs. normal: 82.0 ± 2.0%, p ≤ 0.01). However, no significant changes were recognized in inflammatory bowel disease cases. According to in silico analysis of microarray data, altered mRNA levels of several DNA methylation-related enzymes were detected in tumours vs. healthy biopsies, namely one-carbon metabolism-related genes-which met our analysing criteria-showed upregulation, while FOLR2 was downregulated. Using immunohistochemistry, DNMTs, and FOLR2 expression were confirmed. Moreover, significantly diminished folic acid and S-adenosylmethionine levels were observed in parallel with decreasing 5-methylcytosine staining in tumours compared to normal adjacent to tumour tissues (p ≤ 0.05).Our results suggest that LINE-1 hypomethylation may have a distinguishing value in precancerous stages compared to healthy samples in liquid biopsies. Furthermore, the reduction of global DNA methylation level could be linked to reduced methyl-donor availability with the contribution of decreased FOLR2 expression. Funding 2014755 /api/funding/2014755 false true Funding 2014756 /api/funding/2014756 false true Funding 2014757 /api/funding/2014757 false true true true NATIONAL 2022 true true true false true false GOLD 2026-09-16 true https://doi.org/10.1186/s12885-022-09659-1 33 0 33 32 1 33 33 31 30 33 33 32 32 32 1 0 33 32 33 32 0 5 5 Folyóiratcikk Journal Article 24 32 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 3 2 3 2 2023 0 3 3 3 3 2024 0 9 9 9 9 2025 0 7 7 7 7 2026 0 11 11 11 11 Q1 false 10000768,1405456 false false false 2022-06-09T07:55:32.564+0000 Belgyógyászati és Hematológiai Klinika (SE / AOK / K); Belgyógyászati és Onkológiai Klinika (SE / AOK / K); Bioinformatikai központ (ÁTE / ÁJI); Endokrinológiai Tanszék (SE / AOK / K / BOK); II. Sz. Belgyógyászati Klinika (SE / AOK / K); MTA-SE Molekuláris Medicina Kutatócsoport (SE / AOK / K / BOK); Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I); Sebészeti, Transzplantációs és Gasztroenterológ... 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/api/keyword/1069451 true 1069451 true Keyword 1513174 /api/keyword/1513174 true true SjrRating 11284838 /api/sjrrating/11284838 88 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1311 /api/classificationexternal/1311 true 1311 true Q1 DIRECT true true /api/publication/32869047 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10079934"><a href="/gui2/?type=authors&mode=browse&sel=10079934" target="_blank">Szigeti Krisztina A ✉ (<span class="authorship-author-name">Szigeti Krisztina Andrea</span> <span class="authorAux-mtmt"> Daganatbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035287"><a href="/gui2/?type=authors&mode=browse&sel=10035287" target="_blank">Kalmár Alexandra (<span class="authorship-author-name">Kalmár Alexandra</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Belgyógyászati és Onkológiai Klinika">BOK</span>/MTA-SE Molekuláris Medicina Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001335"><a href="/gui2/?type=authors&mode=browse&sel=10001335" target="_blank">Galamb Orsolya (<span class="authorship-author-name">Udvardyné Galamb Orsolya</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Belgyógyászati és Onkológiai Klinika">BOK</span>/MTA-SE Molekuláris Medicina Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027279"><a href="/gui2/?type=authors&mode=browse&sel=10027279" target="_blank">Valcz Gábor (<span class="authorship-author-name">Valcz Gábor</span> <span class="authorAux-mtmt"> gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Belgyógyászati és Onkológiai Klinika">BOK</span>/MTA-SE Molekuláris Medicina Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/II. Sz. Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038772"><a href="/gui2/?type=authors&mode=browse&sel=10038772" target="_blank">Barták Barbara K (<span class="authorship-author-name">Barták Barbara Kinga</span> <span class="authorAux-mtmt"> Orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038783"><a href="/gui2/?type=authors&mode=browse&sel=10038783" target="_blank">Nagy Zsófia B (<span class="authorship-author-name">Nagy Zsófia Brigitta</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10056823"><a href="/gui2/?type=authors&mode=browse&sel=10056823" target="_blank">Zsigrai Sára (<span class="authorship-author-name">Zsigrai Sára</span> <span class="authorAux-mtmt"> molekuláris gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10083977"><a href="/gui2/?type=authors&mode=browse&sel=10083977" target="_blank">Felletár Ildikó (<span class="authorship-author-name">Felletár Ildikó</span> <span class="authorAux-mtmt"> gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10036696"><a href="/gui2/?type=authors&mode=browse&sel=10036696" target="_blank">Patai Árpád V (<span class="authorship-author-name">Patai Árpád V</span> <span class="authorAux-mtmt"> Belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Sebészeti, Transzplantációs és Gasztroenterológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025105"><a href="/gui2/?type=authors&mode=browse&sel=10025105" target="_blank">Micsik Tamás (<span class="authorship-author-name">Micsik Tamás</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071890"><a href="/gui2/?type=authors&mode=browse&sel=10071890" target="_blank">Papp Márton (<span class="authorship-author-name">Papp Márton</span> <span class="authorAux-mtmt"> Bioinformatika, Biostatisztika</span>) </a> </span> <span class="author-affil"><span title="Állatorvostudományi Egyetem">ÁTE</span>/<span title="Élelmiszerlánc-biztonsági és Járványvédelmi Intézet">ÉBJI</span>/Bioinformatikai központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Márkus Eszter </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1405456"><a href="/gui2/?type=authors&mode=browse&sel=1405456" target="_blank">Tulassay Zsolt (<span class="authorship-author-name">Tulassay Zsolt</span> <span class="authorAux-mtmt"> belgyógyászat, gastroenterologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Belgyógyászati és Onkológiai Klinika">BOK</span>/MTA-SE Molekuláris Medicina Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000070"><a href="/gui2/?type=authors&mode=browse&sel=10000070" target="_blank">Igaz Peter (<span class="authorship-author-name">Igaz Péter</span> <span class="authorAux-mtmt"> belgyógyászat, endokrinológia, klinikai molekul...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Belgyógyászati és Onkológiai Klinika">BOK</span>/MTA-SE Molekuláris Medicina Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Belgyógyászati és Onkológiai Klinika">BOK</span>/Endokrinológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024031"><a href="/gui2/?type=authors&mode=browse&sel=10024031" target="_blank">Takács István (<span class="authorship-author-name">Takács István</span> <span class="authorAux-mtmt"> Endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000768"><a href="/gui2/?type=authors&mode=browse&sel=10000768" target="_blank">Molnár Béla (<span class="authorship-author-name">Molnár Béla</span> <span class="authorAux-mtmt"> belgyógyászat, gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Belgyógyászati és Onkológiai Klinika">BOK</span>/MTA-SE Molekuláris Medicina Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32869047" target="_blank">Global DNA hypomethylation of colorectal tumours detected in tissue and liquid biopsies may be related to decreased methyl-donor content</a></div> <div> <span class="journal-title">BMC CANCER</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1471-2407">1471-2407</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1471-2407">1471-2407</a>)</span>: <span class="journal-volume">22</span> <span class="journal-issue">1</span> <span class="page"> Paper 605. 11 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1186/s12885-022-09659-1" target="_blank" href="https://doi.org/10.1186/s12885-022-09659-1"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000805205000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000805205000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85131155159" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85131155159"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35655145" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35655145&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Genetics&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 33</span> | Független: 32 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 31 | Scopus jelölt:&nbsp;30 | WoS/Scopus jelölt:&nbsp;33 | DOI jelölt:&nbsp;33 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32869047&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32869047</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (Open access funding provided by Semmelweis University), (2020-1.1.2-PIACI-KFI-2021-00298) Támogató: NKFIH, (Higher Education Institutional Excellence Programme of the Ministry of Human Capacities in Hungary, within the framework of the molecular biology thematic program of the Semmelweis University) </div> <div class="lastModified">Utolsó módosítás: 2023.01.12. 08:43 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Semmelweis University; National Research, Development and Innovation Office, Hungary [2020-1.1.2-PIACI-KFI-2021-00298]; Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary, of the Semmelweis University Funding text: Open access funding provided by Semmelweis University. This research was funded by the Nati...</pre> </div></div>