https://m2.mtmt.hu/ eng 2026-05-30 14:31 JournalArticle 32866658 VALIDATED true Department of Rheumatology & Clinical Immunology, Department of Internal Medicine & Oncology, Hungary Department of Genetics, Cell & Immunobiology, Hungary Heart and Vascular Center, Semmelweis University, Budapest, Hungary Department of Rheumatology, BAZ County Central Hospital, Miskolc, Hungary Department of Rheumatology, Csolnoky Ferenc Hospital, Veszprém, Hungary Department of Rheumatology, Békés County Central Hospital, Gyula, Hungary Department of Rheumatology, Fejér County Saint George Hospital, Székesfehérvár, Hungary Department of Rheumatology & Immunology, University of Pécs Clinical Centre, Pécs, Hungary Department of Internal Medicine, Rheumatology, University of Debrecen Clinical Centre, Debrecen, Hungary Roche (Hungary) Ltd, Budapest, Hungary Rheumatology & Immunology Clinic, University of Szeged Clinical Centre, Szeged, Hungary Cited By :1 Export Date: 22 June 2024 Correspondence Address: Nagy, G.; Department of Rheumatology & Clinical Immunology, Árpád fejedelem útja 7, Hungary; email: nagy.gyorgy2@med.semmelweis-univ.hu Chemicals/CAS: alanine aminotransferase, 9000-86-6, 9014-30-6; aspartate aminotransferase, 9000-97-9; C reactive protein, 9007-41-4; cholesterol, 57-88-5; gamma glutamyltransferase, 85876-02-4; methotrexate, 15475-56-6, 59-05-2, 7413-34-5, 7532-09-4, 6745-93-3, 51865-79-3, 60388-53-6; tocilizumab, 375823-41-9 0 false 2026-05-21T22:51:47.458+0000 2023-10-19T07:08:43.819+0000 2022-06-07T11:14:09.112+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-05-14T11:22:05.889+0000 2026-05-14T11:22:05.889+0000 2023-09-02T13:58:07.343+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10097590 /api/admin/10097590 Orbán Zsófia true true 2024-10-17T16:21:58.800+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Nagy, György Real-world evidence on methotrexate-free subcutaneous tocilizumab therapy in patients with rheumatoid arthritis : 24-week data from the SIMPACT study true true /api/journal/20076352 REVIEWED true false false 20076352 true 2514-1775 Journal FOREIGN 6 2 rkac038 rkac038 13 2022 The aim of the SIMPACT study was to evaluate the efficacy and safety of MTX-free s.c. tocilizumab (TCZ) therapy in RA patients.SIMPACT was an open-label, non-controlled, non-randomized, non-interventional study, in which RA patients for whom the treating physicians ordered s.c. TCZ were observed during a 24-week treatment period in Hungarian centres. Although the use of MTX was avoided during the study period, other conventional synthetic DMARDs, oral CSs and NSAIDs were allowed. Study endpoints included the change in DAS28 and clinical activity index (CDAI) scores, the proportion of patients achieving remission in the whole population and in subgroups defined based on prior RA treatment history, and age, weight or biological sex post hoc. The extent of supplementary medication use was monitored.Three hundred and thirty-seven RA patients were enrolled in 18 study centres. TCZ therapy significantly decreased the disease activity measured by both DAS28 (P = 0.0001) and CDAI (P = 0.0001). Clinical response was more pronounced in biologic-naïve patients and was lower in patients >75 years of age. In the whole population, DAS28 ESR or CRP and CDAI remission rates were 70.10%, 78.95% and 33.59%, respectively. In patients <45 years of age, the CDAI remission rate doubled (67.86%). A significant decrease in the frequency of co-administered medication was reported, including oral CSs and DMARDs.Real-world clinical evidence on s.c. TCZ reported here is in line with the efficacy outcomes of randomized clinical trials. Subgroup analysis revealed that TCZ was more effective in biologic-naïve patients and in those <75 years old.ClinicalTrials.gov, http://www.clinicaltrials.gov, NCT02402686. true 2022 true true true false true false GOLD 2026-05-22 true https://doi.org/10.1093/rap/rkac038 4 0 4 4 1 4 4 2 2 2 2 2 2 4 0 0 4 4 4 4 0 3 3 Folyóiratcikk Journal Article 24 4 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat 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style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10025749"><a href="/gui2/?type=authors&mode=browse&sel=10025749" target="_blank">Nagy György ✉ (<span class="authorship-author-name">Nagy György</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Genetics, Cell- and Immunology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Internal Medicine and Oncology">DIMO</span>/Department of Rheumatology and Clinical Immunology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10004870"><a href="/gui2/?type=authors&mode=browse&sel=10004870" target="_blank">Géher Pál (<span class="authorship-author-name">Géher Pál</span> <span class="authorAux-mtmt"> Reumatológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Internal Medicine and Oncology">DIMO</span>/Department of Rheumatology and Clinical Immunology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tamási László </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Drescher Edit </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Keszthelyi Péter </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10072566"><a href="/gui2/?type=authors&mode=browse&sel=10072566" target="_blank">Pulai Judit (<span class="authorship-author-name">Pulai Judit</span> <span class="authorAux-mtmt"> Reumatológia</span>) </a> </span> <span class="author-affil"><span title="Fejér Megyei Szent György Egyetemi Oktató Kórház">FMSZGYEOK</span>/Reumatológia</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000307"><a href="/gui2/?type=authors&mode=browse&sel=10000307" target="_blank">Czirják László (<span class="authorship-author-name">Czirják László</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Rheumatology and Immunology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003464"><a href="/gui2/?type=authors&mode=browse&sel=10003464" target="_blank">Szekanecz Zoltán (<span class="authorship-author-name">Szekanecz Zoltán</span> <span class="authorAux-mtmt"> Reumatológia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Belgyógyászati Intézet">BelgyI</span>/Reumatológiai Tanszék; <span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Belgyógyászati Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021833"><a href="/gui2/?type=authors&mode=browse&sel=10021833" target="_blank">Kiss Gergely (<span class="authorship-author-name">Kiss Gergely</span> <span class="authorAux-mtmt"> biokémia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000086"><a href="/gui2/?type=authors&mode=browse&sel=10000086" target="_blank">Kovács László (<span class="authorship-author-name">Kovács László</span> <span class="authorAux-mtmt"> belgyógyászat, reumatológia, immunológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Albert Szent-Györgyi Medical School">ASZMS</span>/Department of Rheumatology and Immunology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32866658" target="_blank">Real-world evidence on methotrexate-free subcutaneous tocilizumab therapy in patients with rheumatoid arthritis : 24-week data from the SIMPACT study</a></div> <div> <span class="journal-title">RHEUMATOLOGY ADVANCES IN PRACTICE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2514-1775">2514-1775</a>)</span>: <span class="journal-volume">6</span> <span class="journal-issue">2</span> <span class="page"> Paper rkac038. 13 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1093/rap/rkac038" target="_blank" href="https://doi.org/10.1093/rap/rkac038"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000804412400003" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000804412400003"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85132970430" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85132970430"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35663154" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35663154&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" None "> <a style="color:blue" title="https://academic.oup.com/rheumap/advance-article/doi/10.1093/rap/rkac038/6586319" target="_blank" href="https://academic.oup.com/rheumap/advance-article/doi/10.1093/rap/rkac038/6586319"> Other URL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="24509" target="_blank" href="http://publicatio.bibl.u-szeged.hu/24509"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Rheumatology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 4</span> | Independent citation: 4 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 2 | Number of citations in Scopus:&nbsp;2 | WoS/Scopus assigned:&nbsp;2 | Number of citations with DOI:&nbsp;4 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32866658&sort=publishedYear,desc&sort=title"> Number of cited publications: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32866658</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="lastModified">Last Modified: 2023.10.19. 09:08 Ágnes Szemenyeiné Rideg (FM Szent György Kórház admin4) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:21 Gusztáv Ladányi (MTMT API user, admin) Zsófia Orbán (MTMT ellenőrzés, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Rheumatology & Clinical Immunology, Department of Internal Medicine & Oncology, Hungary Department of Genetics, Cell & Immunobiology, Hungary Heart and Vascular Center, Semmelweis University, Budapest, Hungary Department of Rheumatology, BAZ County Central Hospital, Miskolc, Hungary Dep...</pre> </div></div>